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Catalyst: and solvent-free synthesis of imidazo[1,2-a]pyridines

DOI: 10.1590/S0103-50532009000300012

Keywords: imidazo[1,2-a]pyridines, α-haloketones, 2-aminopyridines, catalyst-free, solvent-free.

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Abstract:

a highly efficient and facile method has been described for the synthesis of imidazo[1,2-a]pyridines in good to excellent yields by condensation of the α-haloketones (arcochxr2, ar = c6h5, 4-meoc6h4, 4-clc6h4, 2,4-cl2c6h3; x = br, cl; r2 = h, ch3) with 2-aminopyridines without the use of any additional catalyst and solvent.

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