[1] | Frederickson CJ (1989) Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol 31: 145–238.
|
[2] | Vallee BL, Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73: 79–118.
|
[3] | Hidalgo J, Aschner M, Zatta P, Vasak M (2001) Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 55: 133–145.
|
[4] | Sensi SL, Yin HZ, Weiss JH (2000) AMPA/kainate receptor-triggered Zn2+ entry into cortical neurons induces mitochondrial Zn2+ uptake and persistent mitochondrial dysfunction. Eur J Neurosci 12: 3813–3818.
|
[5] | Malaiyandi LM, Vergun O, Dineley KE, Reynolds IJ (2005) Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms. J Neurochem 93: 1242–1250.
|
[6] | Sensi SL, Paoletti P, Bush AI, Sekler I (2009) Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci 10: 780–791.
|
[7] | Cuajungco MP, Lees GJ (1997) Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4: 137–169.
|
[8] | Capasso M, Jeng JM, Malavolta M, Mocchegiani E, Sensi SL (2005) Zinc dyshomeostasis: a key modulator of neuronal injury. J Alzheimers Dis 8: 93–108.
|
[9] | Frederickson CJ, Koh JY, Bush AI (2005) The neurobiology of zinc in health and disease. Nat Rev Neurosci 6: 449–462.
|
[10] | Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, et al. (2011) Patterns of levels of biological metals in CSF differ among neurodegenerative diseases. J Neurol Sci 303: 95–99.
|
[11] | Li F, Tsien JZ (2009) Memory and the NMDA receptors. N Engl J Med 361: 302–303.
|
[12] | Peters S, Koh J, Choi DW (1987) Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons. Science 236: 589–593.
|
[13] | Molnar P, Nadler JV (2001) Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses. Brain Res 910: 205–207.
|
[14] | Williams K (1996) Separating dual effects of zinc at recombinant N-methyl-D-aspartate receptors. Neurosci Lett 215: 9–12.
|
[15] | Chen N, Moshaver A, Raymond LA (1997) Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Mol Pharmacol 51: 1015–1023.
|
[16] | Paoletti P, Ascher P, Neyton J (1997) High-affinity zinc inhibition of NMDA NR1-NR2A receptors. J Neurosci 17: 5711–5725.
|
[17] | Erreger K, Traynelis SF (2008) Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors. J Physiol 586: 763–778.
|
[18] | Rachline J, Perin-Dureau F, Le Goff A, Neyton J, Paoletti P (2005) The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. J Neurosci 25: 308–317.
|
[19] | Karakas E, Simorowski N, Furukawa H (2009) Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit. EMBO J 28: 3910–3920.
|
[20] | Sensi SL, Canzoniero LM, Yu SP, Ying HS, Koh JY, et al. (1997) Measurement of intracellular free zinc in living cortical neurons: routes of entry. J Neurosci 17: 9554–9564.
|
[21] | Nakashima AS, Dyck RH (2009) Zinc and cortical plasticity. Brain Res Rev 59: 347–373.
|
[22] | Lu YM, Taverna FA, Tu R, Ackerley CA, Wang YT, et al. (2000) Endogenous Zn(2+) is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses. Synapse 38: 187–197.
|
[23] | Takeda A, Fuke S, Ando M, Oku N (2009) Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc. Neuroscience 158: 585–591.
|
[24] | Lee JM, Zipfel GJ, Choi DW (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399: A7–14.
|
[25] | Rowley M, Bristow LJ, Hutson PH (2001) Current and novel approaches to the drug treatment of schizophrenia. J Med Chem 44: 477–501.
|
[26] | Cossarizza A, Baccarani-Contri M, Kalashnikova G, Franceschi C (1993) A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraeth?ylbenzimidazolcarbocyanineiodide (JC-1). Biochem Biophys Res Commun 197: 40–45.
|
[27] | Carriedo SG, Yin HZ, Sensi SL, Weiss JH (1998) J Neurosci. 18: 7727–7738.
|
[28] | Sensi SL, Yin HZ, Carriedo SG, Rao SS, Weiss JH (1999) Proc Natl Acad Sci USA. 96: 2414–2419.
|
[29] | Pellegrini-Giampietro DE, Pulsinelli WA, Zukin RS (1994) NMDA and non-NMDA receptor gene expression following global brain ischemia in rats: effect of NMDA and non-NMDA receptor antagonists. J Neurochem 62: 1067–1073.
|
[30] | Porter NM, Thibault O, Thibault V, Chen KC, Landfield PW (1997) Calcium channel density and hippocampal cell death with age in long-term culture. J Neurosci 17: 5629–5639.
|
[31] | Bernabeu R, Sharp FR (2000) NMDA and AMPA/kainate glutamate receptors modulate dentate neurogenesis and CA3 synapsin-I in normal and ischemic hippocampus. J Cereb Blood Flow Metab 20: 1669–1680.
|
[32] | Bellinger FP, Wilce PA, Bedi KS, Wilson P (2002) Long-lasting synaptic modification in the rat hippocampus resulting from NMDA receptor blockade during development. Synapse 43: 95–101.
|
[33] | Klimaviciusa L, Safiulina D, Kaasik A, Klusa V, Zharkovsky A (2008) The effects of glutamate receptor antagonists on cerebellar granule cell survival and development. Neurotoxicology 29: 101–108.
|
[34] | Paoletti P, Neyton J (2007) NMDA receptor subunits: function and pharmacology. Curr Opin Pharmacol 7: 39–47.
|
[35] | Lau CG, Zukin RS (2007) NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci 8: 413–426.
|
[36] | Nicoll RA, Malenka RC (1999) Expression mechanisms underlying NMDA receptor-dependent long-term potentiation. Ann N Y Acad Sci 868: 515–525.
|
[37] | Williams K (2001) Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action. Curr Drug Targets 2: 285–298.
|
[38] | Neyton J, Paoletti P (2006) Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach. J Neurosci 26: 1331–1333.
|
[39] | Tran NH, Sakai T, Kim SM, Fukui K (2010) NF-kappaB regulates the expression of Nucling, a novel apoptosis regulator, with involvement of proteasome and caspase for its degradation. J Biochem 148: 573–580.
|
[40] | Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000) Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat Neurosci 3: 661–669.
|
[41] | Salter MW, Kalia LV (2004) Src kinases: a hub for NMDA receptor regulation. Nat Rev Neurosci 5: 317–328.
|
[42] | Sheng M (2001) Molecular organization of the postsynaptic specialization. Proc Natl Acad Sci U S A 98: 7058–7061.
|
[43] | Kohr G, Seeburg PH (1996) Subtype-specific regulation of recombinant NMDA receptor-channels by protein tyrosine kinases of the src family. J Physiol 492 (Pt 2): 445–452.
|
[44] | Takagi N, Cheung HH, Bissoon N, Teves L, Wallace MC, et al. (1999) The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. J Cereb Blood Flow Metab 19: 880–888.
|
[45] | Liu Y, Zhang G, Gao C, Hou X (2001) NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A(NR2A) and interaction of Pyk2 and Src with NR2A after transient cerebral ischemia and reperfusion. Brain Res 909: 51–58.
|
[46] | Huang Y, Lu W, Ali DW, Pelkey KA, Pitcher GM, et al. (2001) CAKbeta/Pyk2 kinase is a signaling link for induction of long-term potentiation in CA1 hippocampus. Neuron 29: 485–496.
|
[47] | Kalia LV, Salter MW (2003) Interactions between Src family protein tyrosine kinases and PSD-95. Neuropharmacology 45: 720–728.
|
[48] | Traynelis SF, Burgess MF, Zheng F, Lyuboslavsky P, Powers JL (1998) Control of voltage-independent zinc inhibition of NMDA receptors by the NR1 subunit. J Neurosci 18: 6163–6175.
|
[49] | Choi YB, Lipton SA (1999) Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor. Neuron 23: 171–180.
|
[50] | Fayyazuddin A, Villarroel A, Le Goff A, Lerma J, Neyton J (2000) Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors. Neuron 25: 683–694.
|
[51] | Xie XM, Smart TG (1991) A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission. Nature 349: 521–524.
|
[52] | Kruczek C, Gorg B, Keitel V, Pirev E, Kroncke KD, et al. (2009) Hypoosmotic swelling affects zinc homeostasis in cultured rat astrocytes. Glia 57: 79–92.
|
[53] | Weiss JH, Sensi SL, Koh JY (2000) Zn(2+): a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci 21: 395–401.
|
[54] | Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, et al. (2011) The neurophysiology and pathology of brain zinc. J Neurosci 31: 16076–16085.
|
[55] | Sheng M, Pak DT (1999) Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses. Ann N Y Acad Sci 868: 483–493.
|
[56] | Niethammer M, Kim E, Sheng M (1996) Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 16: 2157–2163.
|
[57] | Scannevin RH, Huganir RL (2000) Postsynaptic organization and regulation of excitatory synapses. Nat Rev Neurosci 1: 133–141.
|
[58] | Kim E, Sheng M (2004) PDZ domain proteins of synapses. Nat Rev Neurosci 5: 771–781.
|
[59] | Suvarna N, Borgland SL, Wang J, Phamluong K, Auberson YP, et al. (2005) Ethanol alters trafficking and functional N-methyl-D-aspartate receptor NR2 subunit ratio via H-Ras. J Biol Chem 280: 31450–31459.
|
[60] | Liao GY, Kreitzer MA, Sweetman BJ, Leonard JP (2000) The postsynaptic density protein PSD-95 differentially regulates insulin- and Src-mediated current modulation of mouse NMDA receptors expressed in Xenopus oocytes. J Neurochem 75: 282–287.
|
[61] | Zhang F, Li C, Wang R, Han D, Zhang QG, et al. (2007) Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. Neuroscience 150: 938–949.
|
[62] | Yu XM, Salter MW (1998) Gain control of NMDA-receptor currents by intracellular sodium. Nature 396: 469–474.
|
[63] | Aras MA, Saadi RA, Aizenman E (2009) Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia. Eur J Neurosci 30: 2250–2257.
|
[64] | Samet JM, Silbajoris R, Wu W, Graves LM (1999) Tyrosine phosphatases as targets in metal-induced signaling in human airway epithelial cells. Am J Respir Cell Mol Biol 21: 357–364.
|
[65] | Tal TL, Graves LM, Silbajoris R, Bromberg PA, Wu W, et al. (2006) Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+. Toxicol Appl Pharmacol 214: 16–23.
|
[66] | Lei G, Xue S, Chery N, Liu Q, Xu J, et al. (2002) Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. EMBO J 21: 2977–2989.
|
[67] | Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, et al. (2002) Reversible memory loss in a mouse transgenic model of Alzheimer’s disease. J Neurosci 22: 6331–6335.
|
[68] | Danscher G, Jensen KB, Frederickson CJ, Kemp K, Andreasen A, et al. (1997) Increased amount of zinc in the hippocampus and amygdala of Alzheimer’s diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material. J Neurosci Methods 76: 53–59.
|
[69] | Lee JY, Mook-Jung I, Koh JY (1999) Histochemically reactive zinc in plaques of the Swedish mutant beta-amyloid precursor protein transgenic mice. J Neurosci 19: RC10.
|
[70] | Suh SW, Jensen KB, Jensen MS, Silva DS, Kesslak PJ, et al. (2000) Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer’s diseased brains. Brain Res 852: 274–278.
|
[71] | Ehlers MD (2003) Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system. Nat Neurosci 6: 231–242.
|
[72] | Cote A, Chiasson M, Peralta MR 3rd, Lafortune K, Pellegrini L, et al (2005) Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus. J Physiol 566: 821–837.
|
[73] | Jiang X, Mu D, Biran V, Faustino J, Chang S, et al. (2008) Activated Src kinases interact with the N-methyl-D-aspartate receptor after neonatal brain ischemia. Ann Neurol 63: 632–641.
|
[74] | Wang WW, Hu SQ, Li C, Zhou C, Qi SH, et al. (2010) Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Brain Res 1328: 162–170.
|
[75] | Yang W, Zheng C, Song Q, Yang X, Qiu S, et al. (2007) A three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1–1a subunit. J Biol Chem 282: 9269–9278.
|
[76] | Ghelli A, Zanna C, Porcelli AM, Schapira AH, Martinuzzi A, et al. (2003) Leber’s hereditary optic neuropathy (LHON) pathogenic mutations induce mitochondrial-dependent apoptotic death in transmitochondrial cells incubated with galactose medium. J Biol Chem 278: 4145–4150.
|
[77] | Chen K, Zhang Q, Wang J, Liu F, Mi M, et al. (2009) Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction. Brain Res 1279: 131–138.
|
[78] | Ji YF, Xu SM, Zhu J, Wang XX, Shen Y (2011) Insulin increases glutamate transporter GLT1 in cultured astrocytes. Biochem Biophys Res Commun 405: 691–696.
|
[79] | Shen Y, Zhou Y, Yang XL (1999) Characterization of AMPA receptors on isolated amacrine-like cells in carp retina. Eur J Neurosci 11: 4233–4240.
|
[80] | Sun CL, Su LD, Li Q, Wang XX, Shen Y (2011) Cerebellar long-term depression is deficient in Niemann-Pick type C disease mice. Cerebellum 10: 88–95.
|
[81] | Losi G, Prybylowski K, Fu Z, Luo J, Wenthold RJ, et al. (2003) PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. J Physiol 548: 21–29.
|