Total synthesis and allelopathic activity of cytosporones A-C

the search for efficient, environmentally friendly herbicides has been the focus of numerous studies on the organic synthesis of compounds isolated from natural sources. cytosporones, which are phenolic lipids isolated from fungi, exhibit noteworthy biological properties. this paper reports the preparation of cytosporones a-c from the same starting material through a short synthetic route, with good yields. all compounds were tested for allelopathic activity on lettuce (lactuca sativa l) seeds. cytosporone a and its methylated precursor showed remarkable allelopathic activity, inhibiting seed germination and plantule growth.