Tissue necrosis after canine bothropic envenoming: a case report

the authors report a case of bothropic envenoming in a male cocker spaniel. the animal was bitten in the ventral thoracic region, receiving treatment 4 hours later. clinical examination revealed an extensive, painful and area of firm edema, absence of local or systemic hemorrhage, without evident neurological alterations. clinical diagnosis was mild bothropic envenoming. treatment consisted of 5 vials of polyvalent snake antivenom, two vials administered intravenously and three subcutaneously. blood clotting time was always within normal values. two days after envenoming, the animal showed hyperthermia and received enrofloxacin (5mg/kg/24h) for 10 days and ketoprofen (1mg/kg/24h) for 5 days. seventy-two hours after envenoming, extensive subcutaneous, muscle fiber, and skin necrosis of approximately 10 cm in diameter was observed. after débridement of necrotic tissues, the area was cleaned with antiseptic solutions. complete healing was observed 55 days after envenoming. the authors discuss whether heterologous serotherapy is effective in preventing tissue necrosis after bothropic envenoming.