Histomorphometric analysis of the repair process of autogenous bone grafts fixed at rat calvaria with cyanoacrylate

objective: the purpose of this study was to perform histological and histometric analyses of the repair process of autogenous bone grafts fixed at rat calvaria with ethyl-cyanoacrylate adhesive. material and methods: thirty-two rats were divided into two groups (n=16), group i - control and group ii - adhesive. osteotomies were made at the right parietal bone for graft obtainment using a 4-mm-diameter trephine drill. then, the bone segments were fixed with the adhesive in the parietal region of the opposite side to the donor site. after 10 and 30 days, 8 animals of each group were euthanized and the calvarias were laboratorially processed for obtaining hematoxylin and eosin-stained slides for histological and histometric analyses. results: an intense inflammatory reaction was observed at the 10-day period. at 30 days, this reaction was less intense, despite the presence of adhesive at the recipient-site/graft interface. graft incorporation to the recipient site was observed only at the control group, which maintained the highest graft size at 10 and 30 days. conclusions: although the fragment was stable, the presence of adhesive in group ii did not allow graft incorporation to the recipient site, determining a localized, discrete and persistent inflammatory reaction.