Associa？？o entre fatores de risco clínicos e laboratoriais e progress？o da doen？a renal cr？nica pré-dialítica

introduction: chronic kidney disease (ckd) is a very common condition that has become a public health issue. knowing more about risk factors associated with the progression of ckd allows therapeutic interventions that may change the natural course of the disease. objective: to evaluate the impact of clinical and laboratory variables at admission on the outcomes death and need for renal replacement therapy (rrt). methods: a retrospective cohort study comprised of 211 adult patients with stages 3-5 ckd, followed-up for 56.6 ± 34.5 months. results: mean age of patients was 65.4 ± 15.1 years and 63.5% were > 60 years. the main causes of ckd were hypertensive nephrosclerosis (29%) and diabetic kidney disease (dkd) (17%). most patients (47.3%) were on stage 4 ckd. the mean annual loss of glomerular filtration rate (gfr) was 0.6 ± 2.5 ml/min/1.73 m2 (median 0.77 ml/min/1.73 m2) after the adjustments for demographic, clinical and laboratory variables, dkd [relative risk (rr) 4.4; 95% confidence interval (ci), 1.47 to 13.2; p = 0.008] was predictive of rrt; age (rr 1.09; 95% ci, 1.04 to 1.15; p < 0.0001) and the non-treatment with angiotensin receptor blocker (arb) (rr 4.18, 95% ci, 1.34 to 12.9; p = 0.01) were predictors of death. renal and patient survival rates were 70.9% and 68.6%, respectively. conclusion: in this study, patients with stage 3-5 ckd treated conservatively showed stabilization of renal function and low mortality, which were impacted by dkd, age and to not using arb, respectively.