Determina？？o de HbA1c por CLAE: interferência de variantes de hemoglobinas S e C e alta concentra？？o de HbF

introduction: diabetes mellitus (dm) is considered an important public health problem. it is highly prevalent and its incidence has progressively increased in recent years. objective: to verify possible variations of glycated hemoglobin (hba1c) concentration in the presence of hb s and hb c and to evaluate the impact of hba1c reduction on clinical evaluation and monitoring of diabetic patients. material and methods: this study comprised 150 diabetic individuals from salvador city, bahia, from both genders and average age of 56 years old. fast blood glucose and hba1c were determined by oxidase-peroxidase and high-performance liquid chromatography (hplc) methods, respectively. results: there were variations in the concentration of hba1c in the presence of hemoglobin variants such as aa (7.85%), as (7.30%), and ac (7.15%). discussion and conclusion: the analytical method used to determine hba1c needs to be chosen according to the general population characteristics and associated comorbidities, since the presence of hemoglobin s and c causes significant reductions in hemoglobin glycation, which may lead to clinical misinterpretation of patients' glycemic control.