Factores de riesgo de fracturas por fragilidad en una cohorte de mujeres espa？olas

introduction: fragility fractures are an important public health issue. the aim of this study was to analyze the association of the main osteoporotic risk factors related to fragility fracture in a cohort of women with an indication of bone densitometry (bd). methods: a retrospective cohort was followed-up until a fragile fracture occurred, in a population of women aged 40 to 90 years with a first visit for bd between january 1992 and february 2008. we calculated the incidence rate of fracture per 1000 women-years of follow-up, and the hazard ratio (hr) of fragile fracture using a cox regression model. results: a total of 49,735 women were studied. the average age of participants was 57.8 years (sd: 8.5). of these, 3631 women (7.1%) reported a new fragility fracture in post-baseline visits. risk factors with higher adjusted hr were age > 75 years compared with age < 55 years (hr: 3.8; 95% ci: 3.3-4.4) and having a bc result evaluated as osteoporosis compared to normal (hr: 2.0; 95% ci: 1.8-2.2). a personal history of humerus, hip or vertebral fractures had an adjusted hr of 1.2 (95% ci: 1.1-1.3). conclusions: the main risk factors for fragility fracture were advanced age, bd result and a personal history of fracture, although 74% of fractures were detected with a bone mineral density classified as normal or osteopenia. other relevant factors were rheumatoid arthritis or having received prolonged corticosteroid therapy.