| [1] | Via S, Gomulkiewicz R, Dejong G, Scheiner SM, Schlichting CD, et al. (1995) Adaptive phenotypic plasticity - consensus and controversy. Trends Ecol Evol 10: 212–217.
|
| [2] | Sarkar S (2004) From the reaktionsnorm to the evolution of adaptive plasticity: A historical sketch, 1909–1999. In: DeWitt TJ, Scheiner SM, editors. Phenotypic plasticity - functional and conceptual approaches. New York: Oxford University Press. pp. 10–30.
|
| [3] | Windig JJ, de Kovel CGF, de Jong G (2004) Genetics and mechanics of plasticity. In: DeWitt TJ, Scheiner SM, editors. Phenotypic plasticity: Functional and conceptual approaches. New York, N.Y.: Oxford University Press. pp. 31–49.
|
| [4] | Via S, Lande R (1985) Genotype-environment interaction and the evolution of phenotypic plasticity. Evolution 39: 505–522.
|
| [5] | Gutteling EW, Riksen JA, Bakker J, Kammenga JE (2007) Mapping phenotypic plasticity and genotype-environment interactions affecting life-history traits in Caenorhabditis elegans. Heredity 98: 28.
|
| [6] | Sambandan D, Carbone MA, Anholt RRH, Mackay TFC (2008) Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Genetics 179: 1079–1088.
|
| [7] | Kalderon D, Rubin GM (1989) cGMP-dependent Protein Kinase genes in Drosophila. J Biol Chem 264: 10738–10748.
|
| [8] | Osborne KA (1997) Natural behavior polymorphism due to a cGMP-dependent Protein Kinase of Drosophila. Science 277: 834–836.
|
| [9] | de Belle JS, Hilliker AJ, Sokolowski MB (1989) Genetic localization of foraging (for): A major gene for larval behavior in Drosophila melanogaster. Genetics 123: 157–164.
|
| [10] | de Belle JS, Sokolowski MB, Hilliker AJ (1993) Genetic analysis of the foraging microregion of Drosophila melanogaster. Genome 36: 94–101.
|
| [11] | Kaun KR, Riedl CAL, Chakaborty-Chatterjee M, Belay AT, Douglas SJ, et al. (2007) Natural variation in food acquisition mediated via a Drosophila cGMP-dependent Protein Kinase. J Exp Biol 210: 3547–3558.
|
| [12] | Graf SA, Sokolowski MB (1989) The rover/sitter Drosophila foraging polymorphism as a function of larval development, food patch quality and starvation. J Insect Behav 2: 301–313.
|
| [13] | Pereira HS, Sokolowski MB (1993) Mutations in the larval foraging gene affect adult locomotory behavior after feeding in Drosophila melanogaster. Proc Natl Acad Sci USA 90: 5044–5046.
|
| [14] | Scheiner R, Sokolowski MB, Erber J (2004) Activity of cGMP-dependent Protein Kinase (PKG) affects sucrose responsiveness and habituation in Drosophila melanogaster. Learn Mem 11: 303–311.
|
| [15] | Belay AT, Scheiner R, So AKC, Douglas SJ, Chakaborty-Chatterjee M, et al. (2007) The foraging gene of Drosophila melanogaster: Spatial-expression analysis and sucrose responsiveness. J Comp Neurol 504: 570–582.
|
| [16] | Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, et al. (2003) DAVID: Database for annotation, visualization, and integrated discovery. Genome Biol 4: P3.
|
| [17] | Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100: 9440–9445.
|
| [18] | Grewal SS (2009) Insulin/Tor signaling in growth and homeostasis: A view from the fly world. Int J Biochem Cell Biol 41: 1006–1010.
|
| [19] | Wu Q, Brown MR (2006) Signaling and function of insulin-like peptides in insects. Annu Rev Entomol 51: 1–24.
|
| [20] | Radimerski T, Montagne J, Rintelen F, Stocker H, van der Kaay J, et al. (2002) dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol 4: 251–255.
|
| [21] | Rintelen F, Stocker H, Thomas G, Hafen E (2001) PDK1 regulates growth through Akt1 and S6k in Drosophila. Proc Natl Acad Sci USA 98: 15020–15025.
|
| [22] | Junger MA, Rintelen F, Stocker H, Wasserman JD, Vegh M, et al. (2003) The Drosophila forkhead transcription factor foxo mediates the reduction in cell number associated with reduced insulin signaling. J Biol 2: 2–17.
|
| [23] | Puig O, Marr MT, Ruhf ML, Tjian R (2003) Control of cell number by Drosophila foxo: Downstream and feedback regulation of the insulin receptor pathway. Genes Dev 17: 2006–2020.
|
| [24] | Puig O, Tjian R (2005) Transcriptional feedback control of insulin receptor by dfoxo/foxo1. Genes Dev 19: 2435–2446.
|
| [25] | Williams KD, Busto M, Suster ML, So AKC, Ben-Shahar Y, et al. (2006) Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase. Proc Natl Acad Sci USA 103: 15911–15915.
|
| [26] | Gibson G, Dworkin I (2004) Uncovering cryptic genetic variation. Nat Rev Genet 5: 681–690.
|
| [27] | Mackay TF (2001) Quantitative trait loci in Drosophila. Nat Rev Genet 2: 11–20.
|
| [28] | Buch S, Melcher C, Bauer M, Katzenberger J, Pankratz MJ (2008) Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell Metab 7: 321–332.
|
| [29] | Gershman B, Puig O, Hang L, Peitzsch RM, Tatar M, et al. (2007) High-resolution dynamics of the transcriptional response to nutrition in Drosophila: A key role for dfoxo. Physiol Genomics 29: 24–34.
|
| [30] | Guertin DA, Guntur KVP, Bell GW, Thoreen CC, Sabatini DM (2006) Functional genomics identifies Tor-regulated genes that control growth and division. Curr Biol 16: 958–970.
|
| [31] | Engel JE, Xie XJ, Sokolowski MB, Wu CF (2000) A cGMP-dependent protein kinase gene, foraging, modifies habituation-like response decrement of the giant fiber escape circuit in Drosophila. Learn Mem 7: 341–352.
|
| [32] | Mery F, Belay AT, Sokolowski MB, Kawecki TJ (2006) Antagonistic effects of natural polymorphism at the foraging locus on short-term learning and long-term memory. J Neurogenet 20: 177–177.
|
| [33] | Kaun KR, Hendel T, Gerber B, Sokolowski MB (2007) Natural variation in Drosophila larval reward learning and memory due to a cGMP-dependent protein kinase. Learn Mem 14: 342–349.
|
| [34] | Mery F, Belay AT, So AK, Sokolowski MB, Kawecki TJ (2007) Natural polymorphism affecting learning and memory in Drosophila. Proc Natl Acad Sci USA 104: 13051–13055.
|
| [35] | Kaun KR, Riedl CAL, Chakaborty-Chatterjee M, Belay AT, Douglas SJ, et al. (2008) Natural variation in plasticity of glucose homeostasis and food intake. J Exp Biol 211: 3160–3166.
|
| [36] | Fitzpatrick MJ, Sokolowski MB (2004) In search of food: Exploring the evolutionary link between cGMP-dependent protein kinase (PKG) and behaviour. Integr Comp Biol 44: 28–36.
|
| [37] | You YJ, Kim J, Raizen DM, Avery L (2008) Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: A model for satiety. Cell Metab 7: 249–257.
|
| [38] | Gray JM (2004) Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature 430: 317–322.
|
| [39] | Ben-Shahar Y, Leung HT, Pak WL, Sokolowski MB, Robinson GE (2003) cGMP-dependent changes in phototaxis: A possible role for the foraging gene in honey bee division of labor. J Exp Biol 206: 2507–2515.
|
| [40] | Ingram KK, Oefner P, Gordon DM (2005) Task-specific expression of the foraging gene in harvester ants. Mol Ecol 14: 813–818.
|
| [41] | Lucas C, Sokolowski MB (2009) Molecular basis for changes in behavioral state in ant social behaviors. Proc Natl Acad Sci USA 106: 6351–6356.
|
| [42] | Lasko P, Sonenberg N (2007) Coordinated transcriptional and translational control in metabolic homeostasis in flies. Genes Dev 21: 235–237.
|
| [43] | Ceddia RB, Bikopoulos GJ, Hilliker AJ, Sweeney G (2003) Insulin stimulates glucose metabolism via the pentose phosphate pathway in Drosophila Kc cells. FEBS Letters 555: 307–310.
|
| [44] | Teleman AA, Chen YW, Cohen SM (2005) Drosophila melted modulates foxo and Tor activity. Dev Cell 9: 271–281.
|
| [45] | Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, et al. (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11: 213–221.
|
| [46] | Bohni R, Riesgo-Escovar J, Oldham S, Brogiolo W, Stocker H, et al. (1999) Autonomous control of cell and organ size by chico, a Drosophila homolog of vertebrate IRS1-4. Cell 97: 865–875.
|
| [47] | Britton JS, Lockwood WK, Li L, Cohen SM, Edgar BA (2002) Drosophila's insulin/PI3-Kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell 2: 239–249.
|
| [48] | Kramer JM, Davidge JT, Lockyer JM, Staveley BE (2003) Expression of Drosophila foxo regulates growth and can phenocopy starvation. BMC Dev Biol 3: 1–14.
|
| [49] | Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M (2004) Drosophila dfoxo controls lifespan and regulates insulin signalling in brain and fat body. Nature 429: 562–566.
|
| [50] | Cohen P, Alessi DR, Cross DA (1997) PDK1, one of the missing links in insulin signal transduction? FEBS Letters 410: 3–10.
|
| [51] | Nayar JK, Vanhande E (1971) Fuel for sustained mosquito flight. J Insect Physiol 17: 471–5.
|
| [52] | Rowley WA (1970) Interval flights and glycogen utilization by mosquito Culex tarsalis. J Insect Physiol 16: 1839–&.
|
| [53] | Wigglesworth VB (1949) The utilization of reserve substances in Drosophila during flight. J Exp Biol 26: 150–163.
|
| [54] | Gade G, Auerswald L (2003) Mode of action of neuropeptides from the adipokinetic hormone family. Gen Comp Endocrinol 132: 10.
|
| [55] | Graves JL, Toolson EC, Jeong C, Vu LN, Rose MR (1992) Desiccation, flight, glycogen, and postponed senescence in Drosophila melanogaster. Physiol Zool 65: 268–286.
|
| [56] | Gibbs AG, Chippindale AK, Rose MR (1997) Physiological mechanisms of evolved desiccation resistance in Drosophila melanogaster. J Exp Biol 200: 1821–1832.
|
| [57] | Hoffmann AA, Parsons PA (1989) Selection for increased desiccation resistance in Drosophila melanogaster: Additive genetic control and correlated responses for other stresses. Genetics 122: 837.
|
| [58] | Hoffmann AA, Harshman LG (1999) Desiccation and starvation resistance in Drosophila: Patterns of variation at the species, population and intrapopulation levels. Heredity 83(Pt 6): 637.
|
| [59] | Ballard JWO, Melvin RG, Simpson SJ (2008) Starvation resistance is positively correlated with body lipid proportion in five wild caught drosophila simulans populations. J Insect Physiol 54: 1371–1376.
|
| [60] | Zhao Z, Zera AJ (2002) Differential lipid biosynthesis underlies a tradeoff between reproduction and flight capability in a wing-polymorphic cricket. Proc Natl Acad Sci USA 99: 16829–16834.
|
| [61] | Zera AJ, Zhao Z (2003) Morph-dependent fatty acid oxidation in a wing-polymorphic cricket: implications for the trade-off between dispersal and reproduction. J Insect Physiol 49: 933–943.
|
| [62] | Houle D (1991) Genetic covariance of fitness correlates: What genetic correlations are made of and why it matters. Evolution 45: 630–648.
|
| [63] | Ota KT, Pierre VJ, Ploski JE, Queen K, Schafe GE (2008) The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP Kinase. Learn Mem 15: 792–805.
|
| [64] | Feil R, Hofmann F, Kleppisch T (2005) Function of cGMP-dependent protein kinases in the nervous system. Rev Neurosci 16: 23–41.
|
| [65] | Liu S, Rao Y, Daw N (2003) Roles of Protein Kinase A and Protein Kinase G in synaptic plasticity in the visual cortex. Cereb Cortex 13: 864–869.
|
| [66] | Wang X, Robinson P (1997) Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. J Neurochem 68: 443–456.
|
| [67] | Dostmann WR, Tegge W, Frank R, Nickl CK, Taylor MS, et al. (2002) Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent Protein Kinase I-alpha. Pharmacol Ther 93: 203–215.
|
| [68] | Stuart JM, Segal E, Koller D, Kim SK (2003) A gene-coexpression network for global discovery of conserved genetic modules. Science 302: 249–255.
|
| [69] | Engel JE, Wu CF (1996) Altered habituation of an identified escape circuit in Drosophila memory mutants. J Neurosci 16: 3486–3499.
|
| [70] | Engel JE, Wu CF (1998) Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila. J Neurosci 18: 2254–2267.
|
| [71] | Renger JJ, Yao WD, Sokolowski MB, Wu CF (1999) Neuronal polymorphism among natural alleles of a cGMP-dependent kinase gene, foraging, in drosophila. J Neurosci 19: RC28.
|
| [72] | Dawson-Scully K, Armstrong GA, Kent C, Robertson RM, Sokolowski MB (2007) Natural variation in the thermotolerance of neural function and behavior due to a cGMP-dependent protein kinase. PLoS ONE 2: e773. doi:10.1371/journal.pone.0000773.
|
| [73] | Greenspan RJ (2001) The flexible genome. Nature Rev Genet 2: 383–387.
|
| [74] | Featherstone DE, Broadie K (2002) Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network. BioEssays 24: 267–274.
|
| [75] | van Swinderen B, Greenspan RJ (2005) Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics 169: 2151–2163.
|
| [76] | Promislow DE (2004) Protein networks, pleiotropy and the evolution of senescence. Proc Biol Sci 271: 1225–1234.
|
| [77] | Benfey PN, Mitchell-Olds T (2008) From genotype to phenotype: systems biology meets natural variation. Science 320: 495–497.
|
| [78] | Greenspan RJ (1997) A kinder, gentler genetic analysis of behavior: Dissection gives way to modulation. Curr Opin Neurobiol 7: 805–811.
|
| [79] | Fitzpatrick MJ, Feder E, Rowe L, Sokolowski MB (2007) Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene. Nature 447: 210–212.
|
| [80] | Toma DP, White KP, Hirsch J, Greenspan RJ (2002) Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait. Nat Genet 31: 349–353.
|
| [81] | Oldham S, Stocker H, Laffargue M, Wittwer F, Wymann M, et al. (2002) The Drosophila insulin/IGF receptor controls growth and size by modulating PTDinsP(3) levels. Development 129: 4103–4109.
|
| [82] | Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, et al. (2001) Extension of life-span by loss of chico, a Drosophila insulin receptor substrate protein. Science 292: 104–106.
|
| [83] | Weinkove D, Neufeld TP, Twardzik T, Waterfield MD, Leevers SJ (1999) Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(a) Phosphoinositide 3-Kinase and its adaptor. Curr Biol 9: 1019–1029.
|
| [84] | Zulak KG, Cornish A, Daskalchuk TE, Deyholos MK, Goodenowe DB, et al. (2007) Gene transcript and metabolite profiling of Elicitor-induced opium poppy cell cultures reveals the coordinate regulation of primary and secondary metabolism. Planta 225: 1085–1106.
|
| [85] | Gray GR, Heath D (2005) A global reorganization of the metabolome in Arabidopsis during cold acclimation is revealed by metabolic fingerprinting. Physiol Plantarum 124: 236–248.
|
| [86] | Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, et al. (2006) From genomics to chemical genomics: new developments in KEGG. Nucl Acids Res 34: D354–D357.
|
| [87] | Smith CA, O'Maille G, Want EJ, Qin C, Trauger SA, et al. (2005) Metlin: A metabolite mass spectral database. Ther Drug Monit 27: 747–751.
|
| [88] | Clark AG (1989) Causes and consequences of variation in energy storage in Drosophila melanogaster. Genetics 123: 131–144.
|
| [89] | Kunst A, et al. (1984) Metabolites 1: Carbohydrates. In: Bergmeyer HU, editor. Weinheim: Verlag Chemie. 163p p. 3rd – ed.
|
| [90] | Dierick HA, Greenspan RJ (2006) Molecular analysis of flies selected for aggressive behavior. Nat Genet 38: 1023–1031.
|
| [91] | Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19: 185–193.
|
| [92] | Schwarz G (1978) Estimating the dimension of a model. Ann Statist 6: 461–464.
|
