Tumores avanzados de cabeza y cuello: Resección total y reconstrucción con colgajos libres y pegamentos biológicos

patients with advanced and recurrent head and neck skin cancer need aggressive and prolonged reconstructive procedures, besides suffering high morbidity, to get safe margins of oncology healing. we treated eleven patients, 7 with squamous cell carcinomas, 3 with basal cell carcinomas and 1 malignant schwanoma, by a combination of craniotomy, basal cranium, surgery and cra-niofacial boarding to reconstruct extensive defects using free muscular and skin flaps in one intervention. fat, muscle and 1 mm ipidural biological adhesive layer (bioglue) was used to seal dural sutures and obliterate potential dead spaces. there were no adverse reactions to the biological adhesive and no patients presented other complications. out of the eleven patients 3 died due to medical complications: lung embolism, late mielodisplasia and myocardial infarction. after 9-58 months follow up none of the patients have presented with recurrent or distal metastasis.