全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Effect of N-acetylcysteine on lung injury induced by skeletal muscle ischemia-reperfusion: histopathological study in rat model

DOI: 10.1590/S0102-86502012000200012

Keywords: acetylcysteine, muscle, skeletal, lung, ischemia, reperfusion, reperfusion injury, histology, rats.

Full-Text   Cite this paper   Add to My Lib

Abstract:

purpose: to investigate whether n-acetylcysteine, a free radicals scavenger has a protective effect against lung injury as a remote organ after skeletal muscle ischemia-reperfusion. methods: twenty wistar male rats were divided randomly into two experimental groups: group ischemia-reperfusion (group i) and group ischemia-reperfusion + n-acetylcysteine (group ii). all animals were undergone two hours of ischemia by occlusion femoral artery and 24h of reperfusion. before clamped the femoral artery, 250 iu heparin was administered via the jugular vein to prevent clotting. rats that were treated with n-acetylcysteine given iv at a dose of 150 mgkg-1, immediately before reperfusion. after 24h of reperfusion, animals were euthanized and left lung harvested for histopathological analysis under light microscopy. results: in the group i, tissues showed histological changes with intra-alveolar edema, intra-alveolar hemorrhage and neutrophilic infiltration. histopathologically, there was a significant difference (p = 0.005) between two groups. conclusion: administration of n-acetylcysteine treatment significantly decreased lung injury induced by skeletal muscle ischemia reperfusion according to histological findings.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133