Nanocluster polyoxometalates with a structure of buckyball (fullerene) are a promising means of targeted delivery of drugs in the body. In this paper, based on an analysis of histological sections of liver and kidney and peripheral blood, showed a significant reduction of toxicity of buckyballs, containing ions of molybdenum (VI), the substitution of Mo (V) ions to Fe (III), in contrast to buckyballs based on Mo (V). The absence of accumulation of molybdenum in rats with a daily intramuscular injection of aqueous solutions of both drugs within a month was confirmed.
References
[1]
S. D. Caruthers, S. A. Wickline and G. M. Lanza, “Nanotechnological Applications in Medicine,” Current Opinion in Biotechnology, Vol. 18, No. 1, 2007, pp. 26- 30. doi:10.1016/j.copbio.2007.01.006
[2]
R. C. Dutta, “Drug Carriers in Pharmaceutical Design: Promises and Progress,” Current Pharmaceutical Design, Vol. 13, No. 7, 2007, pp. 76-79.
doi:10.2174/138161207780249119
[3]
T. Yamase, “Polyoxometalates for Molecular Devices: Antitumor Activity and Luminescence,” Molecular Engineering, Vol. 3, 1996, pp. 365-373.
[4]
A. Müller, E. Krickemeyer, H. B?gge, M. Schidtmann and F. Peters, “Organizational Forms of Matter: An Inorganic Superfullerene and Keplerate Based on Molybdenum Oxide,” Angewandte Chemie International Edition, Vol. 37, No. 24, 1998, pp. 3360-3363.
[5]
A. Müller, S. Sarkar, Q. N. Shah, H. B?gge, M. Schmidtmann, S. Sarkar, P. K?gerler, B. Hauptfleisch, A. X. Trautwein and V. Schünemann, “Archimedian Synthesis and Magic Numbers: ‘Sizing’ Giant Molybdenum— Oxide Based Molecular Spheres of the Keplerate Type,” Angewandte Chemie International Edition, Vol. 38, No. 21, 1999, pp. 3238-3241.
doi:10.1002/(SICI)1521-3773(19991102)38:21<3238::AID-ANIE3238>3.0.CO;2-6
[6]
A. A. Ostroushko, M. O. Tonkushina and N. A. Martynova, “Mass and Charge Transfer in Systems Containing Nanocluster Molybdenum Polyoxometallates with a Fullerene Structure,” Russian Journal of Physical Chemistry A, Vol. 84, No. 6, 2010, pp. 1022-1027.
[7]
A. A. Ostroushko, M. Yu. Sennikov and M. O. Tonkushina, “Interaction of Polyoxometalate Mo132 with Poly (Vinyl Alcohol),” Russian Journal of Inorganic Chemistry, Vol. 54, No. 4, 2009, pp. 611-617.
doi:10.1134/S0036023609040184
[8]
Yu. V. Chistyakov, “Fundamentals of Bioinorganic Chemistry,” ColosS, Moscow, 2007, pp. 400-488.
[9]
A. Sh. Zaychik and L. P. Churilov, “Pathophysiology. Vol. 2: Fundamentals of Pathochemistry,” Elby-SPb, St. Petersburg, 2001, pp. 403-423.
[10]
A. A. Ostroushko, I. G. Danilova, S. J. Medvedeva, I. F. Gette and M. O. Tonkushina, “Studying of Safety of Molybden Nanocluster Polyoxometalates Intended for Address Delivery of Medicinal Substances,” Ural medical Journal, Vol. 9, No. 74, 2010, pp. 114-117.
[11]
A. A. Ostroushko, I. G. Danilova, S. J. Medvedeva, I. F. Gette, A. V. Prokofieva and M. V. Morozova, “Studying of Polyoxometalates with Fullerene Structure as Potential Agents of Address Delivery of Substances,” European Symposium on Biomaterials and Related Areas, B.56, Jena, Germany, 13-14 April 2011.
