Background: Serum pentraxin 3 is an inflammatory biomarker involved in the innate immune system and plays a role in vascular and metabolic inflammation, while anthropometric parameters are used to assess nutritional status and the risk of metabolic disorders. However, the relationship between these variables in individuals without diabetes mellitus remains inconsistent. Objective: This study aimed to analyze the correlation between anthropometric parameters and serum pentraxin 3 levels in non-diabetic adult subjects. Methods: This study used a cross-sectional study design involving 70 subjects. Measurements included body mass index (BMI), mid upper arm circumference (MUAC), waist circumference (WC), and waist-to-hip ratio (WHR), while serum pentraxin 3 levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Data analysis was performed using the Spearman correlation test. Results: BMI (r = ？0.148; p = 0.222), MUAC (r = ？0.227; p = 0.059), waist circumference (r = ？0.182; p = 0.133), and WHR (r = ？0.169; p = 0.163) showed no significant correlations. Overall, all parameters demonstrated weak negative correlations. Conclusion: The results showed that body mass index (BMI), mid upper arm circumference (MUAC), waist circumference (WC), and waist-to-hip ratio (WHR) had no statistically significant correlation with serum pentraxin 3 levels (p > 0.05). Overall, these findings indicate that anthropometric parameters are not significantly associated with serum pentraxin 3 levels, suggesting that body size is not a major factor influencing serum pentraxin 3 levels in non-diabetic adult subjects.
References
[1]
Pulungan, Z.S.A. and Purnomo, E. (2022) Terapi Kelompok Terapeutik Sebagai Upaya Meningkatkan Perkembangan Intimasi Pada Usia Dewasa Muda. Journal of Health Education and Literacy, 5, 33-39. https://doi.org/10.31605/j-healt.v5i1.1666
[2]
Riskesdas (2018) Riset Kesehatan Dasar 2018. Badan Penelitian Dan Pengembangan Kesehatan, 1.
[3]
Yunieswati, W. and Briawan, D. (2014) Status Antropometri Dengan Beberapa Indikator Pada Mahasiswa TPB-IPB. Jurnal Gizi dan Pangan, 9, 181-186.
[4]
Kuriyan, R. (2018) Body Composition Techniques. Indian Journal of Medical Research, 148, 648-658. https://doi.org/10.4103/ijmr.ijmr_1777_18
[5]
Osorio-Conles, O., Guitart, M., Chacón, M.R., Maymo-Masip, E., Moreno-Navarrete, J.M., Montori-Grau, M., et al. (2011) Plasma PTX3 Protein Levels Inversely Correlate with Insulin Secretion and Obesity, Whereas Visceral Adipose Tissue PTX3 Gene Expression Is Increased in Obesity. American Journal of Physiology-Endocrinology and Metabolism, 301, E1254-E1261. https://doi.org/10.1152/ajpendo.00163.2011
[6]
Zatterale, F., Longo, M., Naderi, J., Raciti, G.A., Desiderio, A., Miele, C., et al. (2020) Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes. Frontiers in Physiology, 10, Article No. 1607. https://doi.org/10.3389/fphys.2019.01607
[7]
Ristagno, G., Fumagalli, F., Bottazzi, B., Mantovani, A., Olivari, D., Novelli, D., et al. (2019) Pentraxin 3 in Cardiovascular Disease. Frontiers in Immunology, 10, Article No. 823. https://doi.org/10.3389/fimmu.2019.00823
[8]
Slusher, A.L., Mock, J.T., Whitehurst, M., Maharaj, A. and Huang, C. (2015) The Impact of Obesity on Pentraxin 3 and Inflammatory Milieu to Acute Aerobic Exercise: Clinical and Experimental. Metabolism, 64, 323-329. https://doi.org/10.1016/j.metabol.2014.10.022
[9]
Amelia, F.D. (2022) Korelasi Antara Kadar Pentraxin-3 dan Matrix metalloproteinase-9 Serum dengan Nilai Laju Filtrasi Glomerulus Pada Pasien Penyakit Ginjal Kronis. http://scholar.unand.ac.id/114868/
[10]
Walu？-Miarka, M., Trojak, A., Miarka, P., Kapusta, M., Kawalec, E., Idzior-Walu？, B., et al. (2020) Correlates of Pentraxin 3 Serum Concentration in Men and Women with Type 2 Diabetes. Innate Immunity, 26, 351-357. https://doi.org/10.1177/1753425919891628
[11]
Abu Seman, N., Witasp, A., Wan Mohamud, W.N., Anderstam, B., Brismar, K., Stenvinkel, P., et al. (2013) Evaluation of the Association of Plasma Pentraxin 3 Levels with Type 2 Diabetes and Diabetic Nephropathy in a Malay Population. Journal of Diabetes Research, 2013, Article ID: 298019. https://doi.org/10.1155/2013/298019
[12]
Maulidya, F., Adelina, M. and Alif Hidayat, F. (2018) Periodesasi Perkembangan Dewasa. Journal of Chemical In-formation and Modeling, 53, 1689-1699.
[13]
Mantovani, A., Garlanda, C., Doni, A. and Bottazzi, B. (2008) Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3. Journal of Clinical Immunology, 28, 1-13. https://doi.org/10.1007/s10875-007-9126-7
[14]
Witasp, A., Carrero, J.J., Micha？lsson, K., Ahlstr？m, H., Kullberg, J., Adamsson, V., et al. (2014) Inflammatory Biomarker Pentraxin 3 (PTX3) in Relation to Obesity, Body Fat Depots and Weight Loss. Obesity, 22, 1373-1379. https://doi.org/10.1002/oby.20695
[15]
Shin, M.K., Choi, B., Kim, E., Park, J., Hwang, E.S., Lee, H.J., et al. (2018) Elevated Pentraxin 3 in Obese Adipose Tissue Promotes Adipogenic Differentiation by Activating Neuropeptide Y Signaling. Frontiers in Immunology, 9, Article No. 1790. https://doi.org/10.3389/fimmu.2018.01790
[16]
Yamasaki, K., Kurimura, M., Kasai, T., Sagara, M., Kodama, T. and Inoue, K. (2009) Determination of Physiological Plasma Pentraxin 3 (PTX3) Levels in Healthy Populations. Clinical Chemistry and Laboratory Medicine, 47, 471-477. https://doi.org/10.1515/cclm.2009.110
[17]
Fard, R.M., Sherafat, N.S. and Rashno, M. (2025) Evaluating Pentraxin 3 as a Diagnostic Biomarker for Diabetic Retinopathy: A Systematic Review and Meta-Analysis. Diabetology & Metabolic Syndrome, 17, Article No. 273.
[18]
Kurniawan, L., Bahrun, U., Hatta, M. and Arif, M. (2018) Body Mass, Total Body Fat Percentage, and Visceral Fat Level Predict Insulin Resistance Better than Waist Circumference and Body Mass Index in Healthy Young Male Adults in Indonesia. Journal of Clinical Medicine, 7, Article No. 96. https://doi.org/10.3390/jcm7050096
