Predicting Candidacy for Neurosurgical Intervention in Stroke: A Nomogram and Decision Tree in a Prospective Cohort of 250 Patients at Bouaké Teaching Hospital, C?te d’Ivoire
BackgroundandObjectives: In resource-limited settings, the decision to operate on a stroke rests on individual experience, with no formal tool. We developed and internally validated a model estimating the probability that a patient meets the criteria for a neurosurgical indication at admission. Methods: Prospective cohort of 250 consecutive patients admitted for imaging-confirmed stroke between January 2022 and December 2023. The target outcome was the operative indication recorded in the chart. A logistic regression with backward selection was translated into a nomogram and an integer score, with a classification and regression tree built in parallel. Internal validation replicated the whole process across 1000 bootstrap resamples. Results: An indication was made in 107 patients (42.8%). Four variables were independently associated with it: hydrocephalus (adjusted odds ratio 4.15; 95% CI 2.03 - 8.46), mass effect (2.42), intraventricular extension (2.31) and impaired consciousness (2.23). The apparent area under the curve was 0.77 (0.71 - 0.83), the optimism-corrected area 0.73 and the corrected calibration slope 0.84. The model outperformed existing scores (ICH score 0.66; ≤0.60 for the others). The integer score (0 - 5) reproduced a gradient from 15.7% to 95.0%. Of 107 indications, only 45 were operated on, and none of the 15 aneurysmal indications. The decision tree generalised less well (cross-validated area 0.69). Conclusion: A four-variable bedside tool estimates the probability of a neurosurgical indication in stroke and outperforms prognostic scores repurposed for that end. It documents a 58% access gap. External multicentre validation remains necessary.
References
[1]
Feigin, V.L., Stark, B.A., Johnson, C.O., Roth, G.A., Bisignano, C., Abady, G.G. (2021) Global, Regional, and National Burden of Stroke and Its Risk Factors, 1990-2019: A Systematic Analysis for the Global Burden of Disease Study 2019. TheLancetNeurology, 20, 795-820. https://doi.org/10.1016/s1474-4422(21)00252-0
[2]
Feigin, V.L., Brainin, M., Norrving, B., Martins, S., Sacco, R.L., Hacke, W., et al. (2022) World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. InternationalJournalofStroke, 17, 18-29. https://doi.org/10.1177/17474930211065917
[3]
Johnson, C.O., Nguyen, M., Roth, G.A., Nichols, E., Alam, T., Abate, D., et al. (2019) Global, Regional, and National Burden of Stroke, 1990-2016: A Systematic Analysis for the Global Burden of Disease Study 2016. TheLancetNeurology, 18, 439-458. https://doi.org/10.1016/s1474-4422(19)30034-1
[4]
Kim, J., Thayabaranathan, T., Donnan, G.A., Howard, G., Howard, V.J., Rothwell, P.M., et al. (2020) Global Stroke Statistics 2019. InternationalJournalofStroke, 15, 819-838. https://doi.org/10.1177/1747493020909545
[5]
O’Donnell, M.J., Chin, S.L., Rangarajan, S., Xavier, D., Liu, L., Zhang, H., et al. (2016) Global and Regional Effects of Potentially Modifiable Risk Factors Associated with Acute Stroke in 32 Countries (INTERSTROKE): A Case-Control Study. TheLancet, 388, 761-775. https://doi.org/10.1016/s0140-6736(16)30506-2
[6]
Owolabi, M.O., Sarfo, F., Akinyemi, R., Gebregziabher, M., Akpa, O., Akpalu, A., et al. (2018) Dominant Modifiable Risk Factors for Stroke in Ghana and Nigeria (SIREN): A Case-Control Study. TheLancetGlobalHealth, 6, e436-e446. https://doi.org/10.1016/s2214-109x(18)30002-0
[7]
Adoukonou, T., Kossi, O., Fotso Mefo, P., Agbétou, M., Magne, J., Gbaguidi, G., et al. (2021) Stroke Case Fatality in Sub-Saharan Africa: Systematic Review and Meta-Analysis. InternationalJournalofStroke, 16, 902-916. https://doi.org/10.1177/1747493021990945
[8]
Adeloye, D. (2014) An Estimate of the Incidence and Prevalence of Stroke in Africa: A Systematic Review and Meta-Analysis. PLOSONE, 9, e100724. https://doi.org/10.1371/journal.pone.0100724
[9]
Akinyemi, R.O., Ovbiagele, B., Adeniji, O.A., Sarfo, F.S., Abd-Allah, F., Adoukonou, T., et al. (2021) Stroke in Africa: Profile, Progress, Prospects and Priorities. NatureReviewsNeurology, 17, 634-656. https://doi.org/10.1038/s41582-021-00542-4
[10]
Owolabi, M., Akarolo-Anthony, S., Akinyemi, R., Arnett, D., Gebregziabher, M., Jenkins, C., et al. (2015) The Burden of Stroke in Africa: A Glance at the Present and a Glimpse into the Future: Review Article. CardiovascularJournalofAfrica, 26, S27-S38. https://doi.org/10.5830/cvja-2015-038
[11]
Akinyemi, R., Sarfo, F., Abd-Allah, F., Ogun, Y., Belo, M., Francis, P., et al. (2020) Conceptual Framework for Establishing the African Stroke Organization. InternationalJournalofStroke, 16, 93-99. https://doi.org/10.1177/1747493019897871
[12]
Sarfo, F.S., Akpa, O.M., Ovbiagele, B., Akpalu, A., Wahab, K., Obiako, R., et al. (2023) Patient-Level and System-Level Determinants of Stroke Fatality across 16 Large Hospitals in Ghana and Nigeria: A Prospective Cohort Study. TheLancetGlobalHealth, 11, e575-e585. https://doi.org/10.1016/s2214-109x(23)00038-4
[13]
Mendelow, A.D., Gregson, B.A., Fernandes, H.M., Murray, G.D., Teasdale, G.M., Hope, D.T., et al. (2005) Early Surgery versus Initial Conservative Treatment in Patients with Spontaneous Supratentorial Intracerebral Haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): A Randomised Trial. The Lancet, 365, 387-397. https://doi.org/10.1016/S0140-6736(05)17826-X
[14]
Mendelow, A.D., Gregson, B.A., Rowan, E.N., Murray, G.D., Gholkar, A. and Mitchell, P.M. (2013) Early Surgery versus Initial Conservative Treatment in Patients with Spontaneous Supratentorial Lobar Intracerebral Haematomas (STICH II): A Randomised Trial. TheLancet, 382, 397-408. https://doi.org/10.1016/s0140-6736(13)60986-1
[15]
Hanley, D.F., Thompson, R.E., Rosenblum, M., Yenokyan, G., Lane, K., McBee, N., et al. (2019) Efficacy and Safety of Minimally Invasive Surgery with Thrombolysis in Intracerebral Haemorrhage Evacuation (MISTIE III): A Randomised, Controlled, Open-Label, Blinded Endpoint Phase 3 Trial. TheLancet, 393, 1021-1032. https://doi.org/10.1016/s0140-6736(19)30195-3
[16]
Pradilla, G., Ratcliff, J.J., Hall, A.J., Saville, B.R., Allen, J.W., Paulon, G., et al. (2024) Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage. NewEnglandJournalofMedicine, 390, 1277-1289. https://doi.org/10.1056/nejmoa2308440
[17]
Beck, J., Fung, C., Strbian, D., Bütikofer, L., Z’Graggen, W.J., Lang, M.F., et al. (2024) Decompressive Craniectomy Plus Best Medical Treatment versus Best Medical Treatment Alone for Spontaneous Severe Deep Supratentorial Intracerebral Haemorrhage: A Randomised Controlled Clinical Trial. TheLancet, 403, 2395-2404. https://doi.org/10.1016/s0140-6736(24)00702-5
[18]
Vahedi, K., Hofmeijer, J., Juettler, E., Vicaut, E., George, B., Algra, A., et al. (2007) Early Decompressive Surgery in Malignant Infarction of the Middle Cerebral Artery: A Pooled Analysis of Three Randomised Controlled Trials. TheLancetNeurology, 6, 215-222. https://doi.org/10.1016/s1474-4422(07)70036-4
[19]
Molyneux, A.J., Kerr, R.S., Yu, L., Clarke, M., Sneade, M., Yarnold, J.A., et al. (2005) International Subarachnoid Aneurysm Trial (ISAT) of Neurosurgical Clipping versus Endovascular Coiling in 2143 Patients with Ruptured Intracranial Aneurysms: A Randomised Comparison of Effects on Survival, Dependency, Seizures, Rebleeding, Subgroups, and Aneurysm Occlusion. TheLancet, 366, 809-817. https://doi.org/10.1016/s0140-6736(05)67214-5
[20]
Collins, G.S., Reitsma, J.B., Altman, D.G. and Moons, K.G.M. (2015) Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD): The TRIPOD Statement. AnnalsofInternalMedicine, 162, 55-63. https://doi.org/10.7326/m14-0697
[21]
Iasonos, A., Schrag, D., Raj, G.V. and Panageas, K.S. (2008) How to Build and Interpret a Nomogram for Cancer Prognosis. JournalofClinicalOncology, 26, 1364-1370. https://doi.org/10.1200/jco.2007.12.9791
[22]
Steyerberg, E.W., Harrell, F.E., Borsboom, G.J.J.M., Eijkemans, M.J.C., Vergouwe, Y. and Habbema, J.D.F. (2001) Internal Validation of Predictive Models: Efficiency of Some Procedures for Logistic Regression Analysis. JournalofClinicalEpidemiology, 54, 774-781. https://doi.org/10.1016/s0895-4356(01)00341-9
[23]
Breiman, L., Friedman, J.H., Olshen, R.A. and Stone, C.J. (1984) Classification and Regression Trees. Wadsworth International Group.
[24]
von Elm, E., Altman, D.G., Egger, M., Pocock, S.J., G?tzsche, P.C. and Vandenbroucke, J.P. (2007) The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies. TheLancet, 370, 1453-1457. https://doi.org/10.1016/s0140-6736(07)61602-x
[25]
Hemphill, J.C., Bonovich, D.C., Besmertis, L., Manley, G.T. and Johnston, S.C. (2001) The ICH Score: A Simple, Reliable Grading Scale for Intracerebral Hemorrhage. Stroke, 32, 891-897. https://doi.org/10.1161/01.str.32.4.891
[26]
Greenberg, S.M., Ziai, W.C., Cordonnier, C., Dowlatshahi, D., Francis, B., Goldstein, J.N., et al. (2022) 2022 Guideline for the Management of Patients with Spontaneous Intracerebral Hemorrhage: A Guideline from the American Heart Association/American Stroke Association. Stroke, 53, e282-e361. https://doi.org/10.1161/str.0000000000000407
[27]
Steiner, T., Salman, R.A., Beer, R., Christensen, H., Cordonnier, C., Csiba, L., et al. (2014) European Stroke Organisation (ESO) Guidelines for the Management of Spontaneous Intracerebral Hemorrhage. InternationalJournalofStroke, 9, 840-855. https://doi.org/10.1111/ijs.12309
[28]
Steiner, T., Purrucker, J.C., Aguiar de Sousa, D., Apostolaki-Hansson, T., Beck, J., Christensen, H., et al. (2025) European Stroke Organisation (ESO) and European Association of Neurosurgical Societies (EANS) Guideline on Stroke Due to Spontaneous Intracerebral Haemorrhage. EuropeanStrokeJournal, 10, 1007-1086. https://doi.org/10.1177/23969873251340815
[29]
Powers, W.J., Rabinstein, A.A., Ackerson, T., Adeoye, O.M., Bambakidis, N.C., Becker, K., et al. (2019) Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke, 50, e344-e418. https://doi.org/10.1161/str.0000000000000211
[30]
Gregório, T., Pipa, S., Cavaleiro, P., Atanásio, G., Albuquerque, I., Chaves, P.C., et al. (2018) Prognostic Models for Intracerebral Hemorrhage: Systematic Review and Meta-Analysis. BMCMedicalResearchMethodology, 18, Article No. 145. https://doi.org/10.1186/s12874-018-0613-8
[31]
Lin, F., He, Q., Zhuo, L., Zhao, M., Ye, G., Gao, Z., et al. (2023) A Nomogram Predictive Model for Long-Term Survival in Spontaneous Intracerebral Hemorrhage Patients without Cerebral Herniation at Admission. ScientificReports, 13, Article No. 3126. https://doi.org/10.1038/s41598-022-26176-0
[32]
Dewan, M.C., Rattani, A., Fieggen, G., Arraez, M.A., Servadei, F., Boop, F.A., et al. (2019) Global Neurosurgery: The Current Capacity and Deficit in the Provision of Essential Neurosurgical Care. Executive Summary of the Global Neurosurgery Initiative at the Program in Global Surgery and Social Change. JournalofNeurosurgery, 130, 1055-1064. https://doi.org/10.3171/2017.11.jns171500
[33]
Punchak, M., Mukhopadhyay, S., Sachdev, S., Hung, Y., Peeters, S., Rattani, A., et al. (2018) Neurosurgical Care: Availability and Access in Low-Income and Middle-Income Countries. WorldNeurosurgery, 112, e240-e254. https://doi.org/10.1016/j.wneu.2018.01.029
[34]
Gupta, S., Gal, Z.T., Athni, T.S., Calderon, C., Callison, W.é., Dada, O.E., et al. (2024) Mapping the Global Neurosurgery Workforce. Part 1: Consultant Neurosurgeon Density. JournalofNeurosurgery, 141, 1-9. https://doi.org/10.3171/2023.9.jns231615
[35]
Wolff, R.F., Moons, K.G.M., Riley, R.D., Whiting, P.F., Westwood, M., Collins, G.S., et al. (2019) PROBAST: A Tool to Assess the Risk of Bias and Applicability of Prediction Model Studies. AnnalsofInternalMedicine, 170, 51-58. https://doi.org/10.7326/m18-1376
[36]
Collins, G.S., Moons, K.G.M., Dhiman, P., Riley, R.D., Beam, A.L., Van Calster, B., et al. (2024) TRIPOD + AI Statement: Updated Guidance for Reporting Clinical Prediction Models That Use Regression or Machine Learning Methods. BMJ, 385, e078378. https://doi.org/10.1136/bmj-2023-078378