Introduction: A significant number of individuals living with type 2 diabetes (T2D) have poor glycemic control. The quality and adherence to antidiabetic prescriptions are essential for optimizing patient care. Objective: To examine the status of antidiabetic medication prescribing among patients with type 2 diabetes followed at the CNHU-HKM. Method: This was a cross-sectional, descriptive, and analytical study conducted over three months in the Endocrinology, Metabolism, and Nutrition Department at CNHU-HKM. Prescription adherence was assessed according to the 2019 African Consensus on the Management of Hyperglycemia in T2D and the 2025 ADA recommendations. Results: A total of 111 patients were included in the study. The mean age was 61.4 ± 11.1 years, with a predominance of female patients. Overweight and obesity affected 38.7% and 34.2% of the participants, respectively. Metformin was the most commonly prescribed medication (92.3%), followed by sulfonylureas (65.4%). Compliance with the African consensus was 83.8%, and 17.1% of prescriptions complied with both sets of guidelines. The main factors associated with compliance with the African consensus were the absence of treatment inertia (p < 0.001), the absence of nephropathy (p = 0.022). Among the patients included, 62.2% had good glycemic control (HbA1c ≤ 7%). Conclusion: Compliance with the recommendations is generally satisfactory according to the African consensus but remains insufficient according to the 2025 ADA recommendations. Treatment inertia and diabetic nephropathy are the main factors associated with adherence to treatment regimens.
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