Healthcare Professionals’ Perceptions and Clinical Experience with IBUCAP NIGHT for Pain-Associated Sleep Disturbances: A Cross-Sectional Survey in Angola
Introduction: Pain-induced sleep disturbances significantly impact quality of life. To address this, IBUCAP NIGHT, containing Ibuprofen 200 mg and Diphenhydramine Citrate 38 mg, offers a dual-action approach for pain relief and improving sleep. To address the limited real-world evidence regarding clinician experience with IBUCAP NIGHT in Angola, this Healthcare Professional Experience Research (HPER) survey was undertaken. The primary objective of this survey was to evaluate healthcare professionals’ perceptions of the utilization, effectiveness, tolerability, and prescribing practices of IBUCAP NIGHT for the management of pain-associated sleep disturbances in routine clinical practice in Angola. Methodology: A descriptive cross-sectional HPER survey was conducted among 29 participating clinicians in Angola using a structured 20-item questionnaire. Results: Clinicians reported a median patient load of 175 per month, with 10% suffering from pain-induced sleeplessness. The most common sleep disturbances were difficulty in falling asleep (75.9%), inability to stay asleep (65.5%) & frequent awakenings (44.8%). Majority of these patients had acute dental pain (75.9%) and chronic back pain (65.5%). 75.9% responding physicians deemed two capsules as the optimal dose & 62.1% recommended treatment for less than one week. Side effects were mild, with drowsiness being the most frequent (82.8%). Clinicians rated the overall efficacy of IBUCAP NIGHT as “good to excellent” (89.6%), and 89.7% believed it effectively addressed the dual concerns of pain and sleeplessness. Conclusion: Participating clinicians perceived IBUCAP NIGHT as effective/or may improve pain management while also improving sleep quality, with most reporting favorable impressions of patients’ quality of life. These findings reflect clinician-reported perceptions rather than direct patient outcome assessment.
References
[1]
National Institute of Neurological Disorders and Stroke (2025) Pain. https://www.ninds.nih.gov/health-information/disorders/pain
[2]
Trachsel, L.A., Munakomi, S. and Cascella, M. (2023) Pain Theory. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK545194/
[3]
Dydyk, A.M. and Conermann, T. (2025) Chronic Pain. StatPearls. http://www.ncbi.nlm.nih.gov/books/NBK553030/
[4]
Finan, P.H., Goodin, B.R. and Smith, M.T. (2013) The Association of Sleep and Pain: An Update and a Path Forward. TheJournalofPain, 14, 1539-1552. https://doi.org/10.1016/j.jpain.2013.08.007
[5]
Seiger, A.N., Penzel, T. and Fietze, I. (2024) Chronic Pain Management and Sleep Disorders. CellReportsMedicine, 5, Article ID: 101761. https://doi.org/10.1016/j.xcrm.2024.101761
[6]
Banks, S. and Dinges, D.F. (2007) Behavioral and Physiological Consequences of Sleep Restriction. JournalofClinicalSleepMedicine, 3, 519-528. https://doi.org/10.5664/jcsm.26918
[7]
Yi, D., Yang, M., Luo, Q., Li, H., Kong, L. and Cheng, Q. (2024) Bidirectional Relationship between Pain and Sleep Disturbance in Middle-Aged and Older Adults: Evidence from the China Health and Retirement Longitudinal Study. FrontiersinPsychiatry, 15, Article 1485822. https://doi.org/10.3389/fpsyt.2024.1485822
[8]
Haack, M., Simpson, N., Sethna, N., Kaur, S. and Mullington, J. (2019) Sleep Deficiency and Chronic Pain: Potential Underlying Mechanisms and Clinical Implications. Neuropsychopharmacology, 45, 205-216. https://doi.org/10.1038/s41386-019-0439-z
[9]
McHugh, J.M. and McHugh, W.B. (2000) Pain: Neuroanatomy, Chemical Mediators, and Clinical Implications. AACNClinicalIssues: AdvancedPracticeinAcute&CriticalCare, 11, 168-178. https://doi.org/10.1097/00044067-200005000-00003
[10]
Haas, H.L., Sergeeva, O.A. and Selbach, O. (2008) Histamine in the Nervous System. PhysiologicalReviews, 88, 1183-1241. https://doi.org/10.1152/physrev.00043.2007
[11]
Ricciotti, E. and FitzGerald, G.A. (2011) Prostaglandins and Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 986-1000. https://doi.org/10.1161/atvbaha.110.207449
[12]
Grosser, T., Smyth, E. and FitzGerald, G. (2022) Pharmacotherapy of Inflammation, Fever, Pain, and Gout. In: Brunton, L. and Knollmann, B., Eds., Goodman & Gilman’s The Pharmacological Basis of Therapeutics (14th Edition), McGraw Hill, 829-856.
[13]
FDA (2005) Advil PM Summary Basis of Approval-Medical Review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2005/021393s000_Advil_PM_MedR.pdf
[14]
Gillin, J.C., Spinweber, C.L. and Johnson, L.C. (1989) Rebound Insomnia: A Critical Review. JournalofClinicalPsychopharmacology, 9, 161-172. https://doi.org/10.1097/00004714-198906000-00002
[15]
Roehrs, T.A., Zorick, F.J., Wittig, R.M. and Roth, T. (1986) Dose Determinants of Rebound Insomnia. BritishJournalofClinicalPharmacology, 22, 143-147. https://doi.org/10.1111/j.1365-2125.1986.tb05241.x
[16]
Teutsch, G., Mahler, D.L., Brown, C.R., Forrest, W.H., James, K.E. and Brown, B.W. (1975) Hypnotic Efficacy of Diphenhydramine, Methapyrilene, and Pentobarbital. ClinicalPharmacology&Therapeutics, 17, 195-201. https://doi.org/10.1002/cpt1975172195
[17]
Borbély, A.A. and Youmbi-Balderer, G. (1998) Effect of Diphenhydramine on Subjective Sleep Parameters and on Motor Activity during Bedtime. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 26, 392-396.
[18]
Katayose, Y., Aritake, S., Kitamura, S., Enomoto, M., Hida, A., Takahashi, K., et al. (2012) Carryover Effect on Next-Day Sleepiness and Psychomotor Performance of Nighttime Administered Antihistaminic Drugs: A Randomized Controlled Trial. HumanPsychopharmacology: ClinicalandExperimental, 27, 428-436. https://doi.org/10.1002/hup.2244
[19]
Kudo, Y. and Kurihara, M. (1990) Clinical Evaluation of Diphenhydramine Hydrochloride for the Treatment of Insomnia in Psychiatric Patients: A Double-Blind Study. TheJournalofClinicalPharmacology, 30, 1041-1048. https://doi.org/10.1002/j.1552-4604.1990.tb03592.x
[20]
Stewart, R.B., Meuleman, J.R., Nelson, R.C. and Clark, R.L. (1987) Evaluation of Temazepam and Diphenhydramine as Hypnotics in a Nursing-Home Population. DrugIntelligence&ClinicalPharmacy, 21, 716-720. https://doi.org/10.1177/106002808702100908
[21]
Morin, C.M., Koetter, U., Bastien, C., Ware, J.C. and Wooten, V. (2005) Valerian-Hops Combination and Diphenhydramine for Treating Insomnia: A Randomized Placebo-Controlled Clinical Trial. Sleep, 28, 1465-1471. https://doi.org/10.1093/sleep/28.11.1465
[22]
Hester, J. and Tang, N.K.Y. (2008) Insomnia Co-Occurring with Chronic Pain: Clinical Features, Interaction, Assessments and Possible Interventions. ReviewsinPain, 2, 2-7. https://doi.org/10.1177/204946370800200102
[23]
Roehrs, T., Merlotti, L., Zorick, F. and Roth, T. (1992) Rebound Insomnia in Normals and Patients with Insomnia after Abrupt and Tapered Discontinuation. Psychopharmacology, 108, 67-71. https://doi.org/10.1007/bf02245287
[24]
Morin, C.M., Koetter, U., Bastien, C., Ware, J.C. and Wooten, V. (2005) Valerian-Hops Combination and Diphenhydramine for Treating Insomnia: A Randomized Placebo-Controlled Clinical Trial. Sleep, 28, 1465-1471. https://doi.org/10.1093/sleep/28.11.1465