Bacterial cellulose (BC) has been established as a remarkably versatile biomaterial. Excellent properties of BC laid the foundations for its application as a dressing in wound healing. Recent strategies include compounds loaded on to BC for the enhancement of its properties. We obtained BC from a fermentation process modified by the addition of Green Propolis and Usnic Acid to the culture medium and natural materials before the inoculation of bacteria. Here, we show some results of our investigation of this BC loaded biomaterial in the field of regenerative medicine. The great recovery and absence of adverse effects in cases here presented support its continuous investigation for the treatment of extreme conditions for wound healing.
References
[1]
Sen, C.K. (2019) Human Wounds and Its Burden: An Updated Compendium of Estimates. AdvancesinWoundCare, 8, 39-48. https://doi.org/10.1089/wound.2019.0946
[2]
Lindholm, C. and Searle, R. (2016) Wound Management for the 21st Century: Combining Effectiveness and Efficiency. InternationalWoundJournal, 13, 5-15. https://doi.org/10.1111/iwj.12623
[3]
Olsson, M., J？rbrink, K., Divakar, U., Bajpai, R., Upton, Z., Schmidtchen, A., et al. (2019) The Humanistic and Economic Burden of Chronic Wounds: A Systematic Review. WoundRepairandRegeneration, 27, 114-125. https://doi.org/10.1111/wrr.12683
[4]
Picheth, G.F., Pirich, C.L., Sierakowski, M.R., Woehl, M.A., Sakakibara, C.N., de Souza, C.F., et al. (2017) Bacterial Cellulose in Biomedical Applications: A Review. InternationalJournalofBiologicalMacromolecules, 104, 97-106. https://doi.org/10.1016/j.ijbiomac.2017.05.171
[5]
Rajwade, J.M., Paknikar, K.M. and Kumbhar, J.V. (2015) Applications of Bacterial Cellulose and Its Composites in Biomedicine. AppliedMicrobiologyandBiotechnology, 99, 2491-2511. https://doi.org/10.1007/s00253-015-6426-3
[6]
Klemm, D., Kramer, F., Moritz, S., Lindstr？m, T., Ankerfors, M., Gray, D., et al. (2011) Nanocelluloses: A New Family of Nature‐Based Materials. Angewandte ChemieInternationalEdition, 50, 5438-5466. https://doi.org/10.1002/anie.201001273
[7]
Portela, R., Leal, C.R., Almeida, P.L. and Sobral, R.G. (2019) Bacterial Cellulose: A Versatile Biopolymer for Wound Dressing Applications. Molecules, 24, Article No. 1931.
[8]
Sulaeva, I., Henniges, U., Rosenau, T. and Potthast, A. (2015) Bacterial Cellulose as a Material for Wound Treatment: Properties and Modifications. a Review. BiotechnologyAdvances, 33, 1547-1571. https://doi.org/10.1016/j.biotechadv.2015.07.009
[9]
Fu, L., Zhang, J. and Yang, G. (2013) Present Status and Applications of Bacterial Cellulose-Based Materials for Skin Tissue Repair. CarbohydratePolymers, 92, 1432-1442. https://doi.org/10.1016/j.carbpol.2012.10.071
[10]
Basmaji, P., Molina de Olyveira, G. and M. Kanjou, M. (2021) Skin Cancer Treatment by Nanoskin Cellulose: Future Cancer Wound Healing. JournalofBiomaterialsandNanobiotechnology, 12, 1-6. https://doi.org/10.4236/jbnb.2021.121001
[11]
Al Mualla, S., Al Nabooda, M., Salman, N.S., Basmaji, P., De Olyveira, G.M., Manzine Costa, L.M., et al. (2018) Special Nanoskin-ACT-Biological Membranes from Deep Wounds. JournalofBiomaterialsandNanobiotechnology, 9, 79-88. https://doi.org/10.4236/jbnb.2018.91007
[12]
Kanjou, M., Abdulhakim, H., Olyveira, G.M. and Basmaji, P. (2019) 3-D Print Celulose Nanoskin: Future Diabetic Wound Healing. JournalofBiomaterialsandNanobiotechnology, 10, 190-195. https://doi.org/10.4236/jbnb.2019.104011
[13]
Basmaji, P. (2020) First Breast Cancer Treatment Naturally by Nanoskin Act. JournalofBiomaterialsandNanobiotechnology, 11, 179-187. https://doi.org/10.4236/jbnb.2020.113011
[14]
Horue, M., Silva, J.M., Berti, I.R., Brand？o, L.R., Barud, H.S. and Castro, G.R. (2023) Bacterial Cellulose-Based Materials as Dressings for Wound Healing. Pharmaceutics, 15, Article 424. https://doi.org/10.3390/pharmaceutics15020424
[15]
Machado Godoi, M., Peruzzi, C.P., Hoepers, J.V.A., da Silva, A.M., do Nascimento, H.S.K., Mateus, F.N., et al. (2026) A Modified Bacterial Nanocellulose-Based Advanced Therapy Product Accelerates Third-Degree Burn Healing in Murine Models. npj Regenerative Medicine. https://doi.org/10.1038/s41536-026-00470-1
[16]
Gorgieva, S. (2020) Bacterial Cellulose as a Versatile Platform for Research and Development of Biomedical Materials. Processes, 8, Article 624. https://doi.org/10.3390/pr8050624
[17]
Wong, A., Malvestiti, A.A. and Hafner, M.F.S. (2016) Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review. Revista da Associa？？o Médica Brasileira, 62, 468-473. https://doi.org/10.1590/1806-9282.62.05.468
[18]
Frantz, R., Huang, S., Are, A. and Motaparthi, K. (2021) Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management. Medicina, 57, Article 895. https://doi.org/10.3390/medicina57090895
[19]
Prompers, L., Huijberts, M., Apelqvist, J., Jude, E., Piaggesi, A., Bakker, K., et al. (2007) Optimal Organization of Health Care in Diabetic Foot Disease: Introduction to the Eurodiale Study. TheInternationalJournalofLowerExtremityWounds, 6, 11-17. https://doi.org/10.1177/1534734606297245
[20]
Wyatt, D., McGowan, D.N. and Najarian, M.P. (1990) Comparison of a Hydrocolloid Dressing and Silver Sulfadiazine Cream in the Outpatient Management of Second-Degree Burns. TheJournalofTrauma: Injury, Infection, andCriticalCare, 30, 857-865. https://doi.org/10.1097/00005373-199007000-00016
[21]
Subrahmanyam, M. (1998) A Prospective Randomised Clinical and Histological Study of Superficial Burn Wound Healing with Honey and Silver Sulfadiazine. Burns, 24, 157-161. https://doi.org/10.1016/s0305-4179(97)00113-7
[22]
Kostogloudis, N., Demiri, E., Tsimponis, A., Dionyssiou, D., Ioannidis, S., Chatziioannidis, I., et al. (2015) Severe Extravasation Injuries in Neonates: A Report of 34 Cases. PediatricDermatology, 32, 830-835. https://doi.org/10.1111/pde.12664
[23]
Masuoka, H. (2016) Non-Operative Treatment for Extensive Skin Necrosis of a Neonatal Dorsal Foot Caused by Extravasation. ClinicalMedicalReviewsandCaseReports, 3, Article No. 082. https://doi.org/10.23937/2378-3656/1410082
