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吖啶衍生物合成研究
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Abstract:
吖啶及其衍生物是一类重要的含氮稠合三环芳烃，其独特的刚性平面共轭结构赋予其优异的电学、光物理及化学性能，在有机合成、材料科学及药物化学等领域备受关注。因此，发展高效、便捷的合成方法始终是该领域的研究重点。本文围绕吖啶及其衍生物的合成策略展开系统综述，重点阐述分子内环化、分子间串联环化及若干特殊反应在目标化合物制备中的应用。通过对各方法的反应特征、底物适用范围及局限性进行归纳与比较，以期为吖啶及其衍生物的合成研究提供有益参考。
Acridine and its derivatives represent an important class of nitrogen-containing fused tricyclic aromatics. Their unique rigid planar conjugated structure imparts outstanding electrical, photophysical, and chemical properties, attracting considerable attention across the fields of organic synthesis, materials science, and medicinal chemistry. Accordingly, the development of efficient and practical synthetic methodologies has remained a central research focus in this area. This review systematically summarizes the synthetic strategies for acridine and its derivatives, with an emphasis on the applications of intramolecular cyclization, intermolecular cascade cyclization, and several specialized reactions in the construction of target compounds. By comparing and evaluating the reaction characteristics, substrate scopes, and limitations of these methods, this review aims to provide useful guidance for the future synthetic study of acridine and its derivatives.
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