Objective: To investigate the bacteriological characteristics of infected diabetic foot lesions at the CNHU-HKM in Cotonou. Patients and Methods: We conducted a descriptive cross-sectional study over a 5-year period, from January 1, 2015 to December 31, 2019, including 102 patients admitted to the Endocrinology and Metabolism Department of CNHU-HKM, Cotonou, for infected diabetic foot lesions and who had undergone bacteriological sampling. Results: A total of 143 bacteria were identified, with 34.3% of samples containing at least two bacteria. Gram-negative bacilli predominated, and the most frequently isolated organisms were Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus. A high frequency of bacterial resistance to antibiotics was observed, including 38.5% and 42.3% of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, respectively. Conclusion: The bacterial flora, predominantly Gram-negative, and the high frequency of bacterial resistance to commonly used antibiotics, highlights the need to reconsider empirical antibiotic therapy choices.
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