Paclitaxel used in chemotherapy of breast cancer is an inhibitor of mitosis and is obtained from plants. They block cell division, disrupt the function of microtubules and some enzyme proteins. They change the metabolism of amino acids and some other substances, such as nucleic acids, fat synthesis, and also affect cellular respiration. When we modeled breast cancer in 6-month-old rats and carried out chemotherapy using paclitaxel, we encountered various pathomorphological changes.
References
[1]
Momenimovahed, Z. and Salehiniya, H. (2019) Epidemiological Characteristics of and Risk Factors for Breast Cancer in the World. BreastCancer: TargetsandTherapy, 11, 151-164. https://doi.org/10.2147/bctt.s176070
[2]
Herbst, R.S. (2006) Therapeutic Options to Target Angiogenesis in Human Malignancies. Expert Opinion on Emerging Drugs, 11, 635-650. https://doi.org/10.1517/14728214.11.4.635
[3]
Khasraw, M., Bell, R. and Dang, C. (2012) Epirubicin: Is It Like Doxorubicin in Breast Cancer? A Clinical Review. The Breast, 21, 142-149. https://doi.org/10.1016/j.breast.2011.12.012
[4]
Stricker-Krongrad, A., Shoemake, C.R., Pereira, M.E., Gad, S.C., Brocksmith, D. and Bouchard, G.F. (2016) Miniature Swine Breeds in Toxicology and Drug Safety Assessments: What to Expect during Clinical and Pathology Evaluations. Toxicologic Pathology, 44, 421-427. https://doi.org/10.1177/0192623315613337
[5]
Alwan, A., MacLean, D.R., Riley, L.M., d’Espaignet, E.T., Mathers, C.D., Stevens, G.A., et al. (2010) Monitoring and Surveillance of Chronic Non-Communicable Diseases: Progress and Capacity in High-Burden Countries. The Lancet, 376, 1861-1868. https://doi.org/10.1016/s0140-6736(10)61853-3
[6]
Wilhelm, S., Carter, C., Lynch, M., Lowinger, T., Dumas, J., Smith, R.A., et al. (2006) Discovery and Development of Sorafenib: A Multikinase Inhibitor for Treating Cancer. Nature Reviews Drug Discovery, 5, 835-844. https://doi.org/10.1038/nrd2130
[7]
Agbai, O.N., Buster, K., Sanchez, M., Hernandez, C., Kundu, R.V., Chiu, M., et al. (2014) Skin Cancer and Photoprotection in People of Color: A Review and Recommendations for Physicians and the Public. Journal of the American Academy of Dermatology, 70, 748-762. https://doi.org/10.1016/j.jaad.2013.11.038
[8]
Andrade, T.A.M., Iyer, A., Das, P.K., Foss, N.T., Garcia, S.B., Coutinho-Netto, J., etal. (2011) The Inflammatory Stimulus of a Natural Latex Biomembrane Improves Healing in Mice. BrazilianJournalofMedicalandBiologicalResearch, 44, 1036-1047. https://doi.org/10.1590/s0100-879x2011007500116
[9]
Elias, P.M., Gruber, R., Crumrine, D., Menon, G., Williams, M.L., Wakefield, J.S., etal. (2014) Formation and Functions of the Corneocyte Lipid Envelope (CLE). BiochimicaetBiophysicaActa—MolecularandCellBiologyofLipids, 1841, 314-318. https://doi.org/10.1016/j.bbalip.2013.09.011.
[10]
Koschwanez, H.E. and Broadbent, E. (2011) The Use of Wound Healing Assessment Methods in Psychological Studies: A Review and Recommendations. British Journal of Health Psychology, 16, 1-32. https://doi.org/10.1348/135910710x524633
[11]
Sung, H., Ferlay, J., Siegel, R.L., Laversanne, M., Soerjomataram, I., Jemal, A., et al. (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 71, 209-249. https://doi.org/10.3322/caac.21660
[12]
Davronova, S., Davronov, R. and Bakhronov, J. (2024) Structural and Functional Features of Immune System Cells in the Dynamics of Experimental Temperature Exposure. BIO Web of Conferences, 121, Article 03017. https://doi.org/10.1051/bioconf/202412103017
[13]
Khalikova, F.Sh., Sultonova, L.J. and Mamedov, U.S. (2025) Morphological Structure of the Thyroid Gland in Rats under Breast Cancer Chemotherapy. Bulletin of Fundamental and Clinic Medicine, 3, 343-350. https://bsmi.uz/en/articles/morphological-structure-of-the-thyroid-gland-in-rats-under-breast-cancer-chemotherapy/
[14]
Bakhronov, J.J., Teshaev, S.J. and Shodieva, M.S. (2021) Morphometric Characteristics of Parts of Rat Kidney Nephron in Normal and under the Influence of an Anti-Septician—Facility 2 Road Stimulator on the Background of Chronic Radiating Disease. International Journal of Pharmaceutical Research, 13, Article 683. https://doi.org/10.31838/ijpr/2021.13.01.102
