全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

中药及其活性成分防治哮喘研究进展
Research Progress on Traditional Chinese Medicine and Its Active Components in the Prevention and Treatment of Asthma

DOI: 10.12677/pi.2026.154036, PP. 337-346

Keywords: 哮喘,发病机制,中药防治,干预机制
Asthma
, Pathogenesis, Prevention and Treatment of Traditional Chinese Medicine, Mechanism of Intervention

Full-Text   Cite this paper   Add to My Lib

Abstract:

哮喘是一种以气道炎症、可逆性气道阻塞和气道重塑为主要病理特征的慢性呼吸系统疾病,临床患者常见呼吸困难、咳嗽、喘息等症状。该病病因复杂,临床表现缺乏特异性,病理改变复杂多样,且缺乏针对性的预防和治疗手段。本文结合近年哮喘发病机制相关研究进展以及中药及其活性成分对哮喘干预机制的实验研究情况进行综述,为深入研究中药抗哮喘的作用机制提供参考和依据。
Asthma is a chronic respiratory disease characterized primarily by airway inflammation, reversible airway obstruction, and airway remodeling. Clinical manifestations commonly include dyspnea, cough, and wheezing. The etiology of this disease is complex, with nonspecific clinical presentations and diverse pathological changes, and there is a lack of targeted preventive and therapeutic interventions. This article reviews the major pathogenic mechanisms of asthma over the past decade and experimental studies on the intervention mechanisms of traditional Chinese medicine (TCM) and its active components in asthma management, aiming to provide references and evidence for further research on the anti-asthmatic mechanisms of TCM.

References

[1]  Praca, E., Jalou, H., Krupp, N., Delecaris, A., Hatch, J., Slaven, J., et al. (2018) Effect of CPAP on Airway Reactivity and Airway Inflammation in Children with Moderate-Severe Asthma. Respirology, 24, 338-344.
https://doi.org/10.1111/resp.13441
[2]  Chen, W., Puttock, E.J., Schatz, M., Crawford, W., Vollmer, W.M., Xie, F., et al. (2024) Risk Factors for Acute Asthma Exacerbations in Adults with Mild Asthma. The Journal of Allergy and Clinical Immunology: In Practice, 12, 2705-2716.e6.
https://doi.org/10.1016/j.jaip.2024.05.034
[3]  Verma, M., Verma, D. and Alam, R. (2021) Role of Type-2 Innate Lymphoid Cells (ILC2s) in Type-2 Asthma. Current Opinion in Allergy & Clinical Immunology, 22, 29-35.
https://doi.org/10.1097/aci.0000000000000798
[4]  Miller, R.L., Grayson, M.H. and Strothman, K. (2021) Advances in Asthma: New Understandings of Asthma’s Natural History, Risk Factors, Underlying Mechanisms, and Clinical Management. Journal of Allergy and Clinical Immunology, 148, 1430-1441.
https://doi.org/10.1016/j.jaci.2021.10.001
[5]  Kim, M., Bae, C., Bok, S., Choi, H., Ahn, T., Cho, S., et al. (2023) Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma. International Journal of Molecular Sciences, 24, Article 12469.
https://doi.org/10.3390/ijms241512469
[6]  Liu, T., Woodruff, P.G. and Zhou, X. (2024) Advances in Non-Type 2 Severe Asthma: From Molecular Insights to Novel Treatment Strategies. European Respiratory Journal, 64, Article ID: 2300826.
https://doi.org/10.1183/13993003.00826-2023
[7]  蔡鑫君, 张相彩, 徐颖颖. 以细胞因子为靶点的抗哮喘药物研究进展[J]. 中国临床药理学与治疗学, 2010, 15(3): 350-355.
[8]  Yang, D., Li, Y., Liu, T., Yang, L., He, L., Huang, T., et al. (2023) Il‐1β Promotes IL‐17A Production of ILC3s to Aggravate Neutrophilic Airway Inflammation in Mice. Immunology, 176, 16-32.
https://doi.org/10.1111/imm.13644
[9]  张国祥, 许文龙. T淋巴细胞及其分泌的细胞因子与哮喘[J]. 蚌埠医学院学报, 2008, 33(1): 125-126.
[10]  Gauthier, M., Kale, S.L. and Ray, A. (2025) T1‐T2 Interplay in the Complex Immune Landscape of Severe Asthma. Immunological Reviews, 330, e70011.
https://doi.org/10.1111/imr.70011
[11]  Olsthoorn, S.E.M., van Krimpen, A., Hendriks, R.W. and Stadhouders, R. (2025) Chronic Inflammation in Asthma: Looking Beyond the Th2 Cell. Immunological Reviews, 330, e70010.
https://doi.org/10.1111/imr.70010
[12]  Gohal, G., Moni, S.S., Bakkari, M.A. and Elmobark, M.E. (2024) A Review on Asthma and Allergy: Current Understanding on Molecular Perspectives. Journal of Clinical Medicine, 13, Article 5775.
https://doi.org/10.3390/jcm13195775
[13]  Hammad, H., Ahmed, E. and Lambrecht, B.N. (2025) Immunotherapy for Asthma. Cellular & Molecular Immunology, 22, 1521-1532.
https://doi.org/10.1038/s41423-025-01357-9
[14]  Li, K., Ji, X., Tian, S., Li, J., Tian, Y., Ma, X., et al. (2025) Oxidative Stress in Asthma Pathogenesis: Mechanistic Insights and Implications for Airway Smooth Muscle Dysfunction. Cell and Tissue Research, 400, 17-34.
https://doi.org/10.1007/s00441-025-03953-7
[15]  周妍, 张旻. 中国《支气管哮喘防治指南(2024年版)》解读[J]. 诊断学理论与实践, 2025, 24(4): 415-422.
[16]  Koumpagioti, D., Dimitroglou, M., Mpoutopoulou, B., Moriki, D. and Douros, K. (2025) The Role of Oxidative Stress in the Pathogenesis of Childhood Asthma: A Comprehensive Review. Children, 12, Article 1110.
https://doi.org/10.3390/children12091110
[17]  Liu, Y., Zhang, M., Wang, T. and Zhang, J. (2025) Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review. Journal of Asthma and Allergy, 18, 1129-1146.
https://doi.org/10.2147/jaa.s529371
[18]  Zhang, B., Feng, X., Tian, L., Xiao, B., Hou, L., Mo, B., et al. (2025) Epithelial-Mesenchymal Transition in Asthma: Its Role and Underlying Regulatory Mechanisms. Frontiers in Immunology, 16, Article 1519998.
https://doi.org/10.3389/fimmu.2025.1519998
[19]  He, H., Ji, X., Cao, L., Wang, Z., Wang, X., Li, X., et al. (2023) Medicine Targeting Epithelial-Mesenchymal Transition to Treat Airway Remodeling and Pulmonary Fibrosis Progression. Canadian Respiratory Journal, 2023, Article ID: 3291957.
https://doi.org/10.1155/2023/3291957
[20]  Gebski, E.B., Anaspure, O., Panettieri, R.A. and Koziol-White, C.J. (2022) Airway Smooth Muscle and Airway Hyperresponsiveness in Asthma: Mechanisms of Airway Smooth Muscle Dysfunction. Minerva Medica, 113, 4-16.
https://doi.org/10.23736/s0026-4806.21.07283-9
[21]  Sahnoon, L., Bajbouj, K., Mahboub, B., Hamoudi, R. and Hamid, Q. (2025) Targeting IL-13 and IL-4 in Asthma: Therapeutic Implications on Airway Remodeling in Severe Asthma. Clinical Reviews in Allergy & Immunology, 68, Article No. 44.
https://doi.org/10.1007/s12016-025-09045-2
[22]  Tiotiu, A., Steiropoulos, P., Novakova, S., Nedeva, D., Novakova, P., Chong-Neto, H., et al. (2025) Airway Remodeling in Asthma: Mechanisms, Diagnosis, Treatment, and Future Directions. Archivos de Bronconeumología, 61, 31-40.
https://doi.org/10.1016/j.arbres.2024.09.007
[23]  Yang, Z., Mao, W., Wang, J. and Yin, L. (2025) The Gut-Lung Axis in Asthma: Microbiota-Driven Mechanisms and Therapeutic Perspectives. Frontiers in Microbiology, 16, Article 1680521.
https://doi.org/10.3389/fmicb.2025.1680521
[24]  Perez-Garcia, J., Cardenas, A., Lorenzo-Diaz, F. and Pino-Yanes, M. (2025) Precision Medicine for Asthma Treatment: Unlocking the Potential of the Epigenome and Microbiome. Journal of Allergy and Clinical Immunology, 155, 298-315.
https://doi.org/10.1016/j.jaci.2024.06.010
[25]  Fang, Z., Fu, Y., Yi, F., Chen, Z., Li, Y., Wang, Z., et al. (2025) Neural Control of the Pathophysiology of Allergic Airway Disease and Its Clinical Implications: A Focus on Allergic Rhinitis and Asthma. Journal of Allergy and Clinical Immunology, 156, 259-269.
https://doi.org/10.1016/j.jaci.2025.05.017
[26]  Kistemaker, L.E.M. and Prakash, Y.S. (2019) Airway Innervation and Plasticity in Asthma. Physiology, 34, 283-298.
https://doi.org/10.1152/physiol.00050.2018
[27]  张亚军, 谭亚琴, 王丽. 哮喘中医证候的古代文献研究[J]. 内蒙古中医药, 2007, 26(3): 46-47.
[28]  Liu, Y., Zha, W., Ma, Y., Chen, F., Zhu, W., Ge, A., et al. (2015) Galangin Attenuates Airway Remodelling by Inhibiting TGF-β1-Mediated ROS Generation and MAPK/Akt Phosphorylation in Asthma. Scientific Reports, 5, Article No. 11758.
https://doi.org/10.1038/srep11758
[29]  Chunlian, W., Heyong, W., Jia, X., Jie, H., Xi, C. and Gentao, L. (2014) Magnolol Inhibits Tumor Necrosis Factor-Α-Induced ICAM-1 Expression via Suppressing NF-κB and MAPK Signaling Pathways in Human Lung Epithelial Cells. Inflammation, 37, 1957-1967.
https://doi.org/10.1007/s10753-014-9928-8
[30]  Li, J., Zheng, M., Wang, C., Jiang, J., Xu, C., Li, L., et al. (2020) Cryptotanshinone Attenuates Allergic Airway Inflammation through Negative Regulation of NF-κB and P38 MAPK. Bioscience, Biotechnology, and Biochemistry, 84, 268-278.
https://doi.org/10.1080/09168451.2019.1687280
[31]  Yu, Q., Shi, Y., Shu, C., Ding, X., Zhu, S., Shen, Z., et al. (2021) Andrographolide Inhibition of Th17-Regulated Cytokines and JAK1/STAT3 Signaling in Ova-Stimulated Asthma in Mice. Evidence-Based Complementary and Alternative Medicine, 2021, Article ID: 6862073.
https://doi.org/10.1155/2021/6862073
[32]  Zhang, H., Zhang, J., Pan, H., Yang, K. and Hu, C. (2024) Astragaloside IV Promotes the Pyroptosis of Airway Smooth Muscle Cells in Childhood Asthma by Suppressing HMGB1/RAGE Axis to Inactivate NF-κB Pathway. Autoimmunity, 57, Article ID: 2387100.
https://doi.org/10.1080/08916934.2024.2387100
[33]  Yang, X. and Wang, F. (2019) The Effect of Astragaloside IV on JAK2‐STAT6 Signalling Pathway in Mouse Model of Ovalbumin‐Induced Asthma. Journal of Animal Physiology and Animal Nutrition, 103, 1578-1584.
https://doi.org/10.1111/jpn.13114
[34]  Xu, L., Li, J., Zhang, Y., Zhao, P. and Zhang, X. (2017) Regulatory Effect of Baicalin on the Imbalance of Th17/Treg Responses in Mice with Allergic Asthma. Journal of Ethnopharmacology, 208, 199-206.
https://doi.org/10.1016/j.jep.2017.07.013
[35]  Quan, J., Xie, D., Li, Z., Yu, X., Liang, Z., Chen, Y., et al. (2024) Luteolin Alleviates Airway Remodeling in Asthma by Inhibiting the Epithelial-Mesenchymal Transition via β-Catenin Regulation. Phytomedicine, 135, Article ID: 156090.
https://doi.org/10.1016/j.phymed.2024.156090
[36]  Yang, X., Lv, J., Li, H., Jiao, B., Zhang, Q., Zhang, Y., et al. (2017) Curcumin Reduces Lung Inflammation via WNT/β-Catenin Signaling in Mouse Model of Asthma. Journal of Asthma, 54, 335-340.
https://doi.org/10.1080/02770903.2016.1218018
[37]  Jia, S., Guo, P., Lu, J., Huang, X., Deng, L., Jin, Y., et al. (2021) Curcumol Ameliorates Lung Inflammation and Airway Remodeling via Inhibiting the Abnormal Activation of the WNT/β-Catenin Pathway in Chronic Asthmatic Mice. Drug Design, Development and Therapy, 15, 2641-2651.
https://doi.org/10.2147/dddt.s292642
[38]  Li, Z., Zheng, J., Zhang, N. and Li, C. (2016) Berberine Improves Airway Inflammation and Inhibits NF-κB Signaling Pathway in an Ovalbumin-Induced Rat Model of Asthma. Journal of Asthma, 53, 999-1005.
https://doi.org/10.1080/02770903.2016.1180530
[39]  Jin, H., Li, J., Zhang, M., Luo, R., Lu, P., Zhang, W., et al. (2021) Berberine-Loaded Biomimetic Nanoparticles Attenuate Inflammation of Experimental Allergic Asthma via Enhancing IL-12 Expression. Frontiers in Pharmacology, 12, Article 724525.
https://doi.org/10.3389/fphar.2021.724525
[40]  Sun, D., Wang, J., Yang, N. and Ma, H. (2016) Matrine Suppresses Airway Inflammation by Downregulating SOCS3 Expression via Inhibition of NF-κB Signaling in Airway Epithelial Cells and Asthmatic Mice. Biochemical and Biophysical Research Communications, 477, 83-90.
https://doi.org/10.1016/j.bbrc.2016.06.024
[41]  He, H., Cao, L., Wang, Z., Wang, Z., Miao, J., Li, X., et al. (2021) Sinomenine Relieves Airway Remodeling by Inhibiting Epithelial-Mesenchymal Transition through Downregulating TGF-β1 and Smad3 Expression in Vitro and in Vivo. Frontiers in Immunology, 12, Article 736479.
https://doi.org/10.3389/fimmu.2021.736479
[42]  Bao, H., Liu, X., Li, Y., Men, X. and Zeng, X. (2016) Sinomenine Attenuates Airway Inflammation and Remodeling in a Mouse Model of Asthma. Molecular Medicine Reports, 13, 2415-2422.
https://doi.org/10.3892/mmr.2016.4816
[43]  Qin, Z., Chen, Y., Liu, N., Wang, Y., Su, L., Liang, B., et al. (2024) Mechanisms of Bushenyiqi Decoction in the Treatment of Asthma: An Investigation Based on Network Pharmacology with Experimental Validation. Frontiers in Pharmacology, 15, Article 1361379.
https://doi.org/10.3389/fphar.2024.1361379
[44]  Chen, Z., Zhou, Y., Tan, Y., He, S., Ji, X., Xiao, B., et al. (2024) Network Pharmacology Analysis and Experimental Validation of Xiao-Qing-Long-Tang’s Therapeutic Effects against Neutrophilic Asthma. Journal of Pharmaceutical and Biomedical Analysis, 243, Article ID: 116063.
https://doi.org/10.1016/j.jpba.2024.116063
[45]  Liu, X., Shen, J., Fan, D., Qiu, X., Guo, Q., Zheng, K., et al. (2017) Yupingfeng San Inhibits NLRP3 Inflammasome to Attenuate the Inflammatory Response in Asthma Mice. Frontiers in Pharmacology, 8, Article 944.
https://doi.org/10.3389/fphar.2017.00944
[46]  Xu, W., Zhao, R. and Yuan, B. (2021) The Therapeutic Effect of Traditional Liujunzi Decoction on Ovalbumin-Induced Asthma in BALB/C Mice. Canadian Respiratory Journal, 2021, Article ID: 6406295.
https://doi.org/10.1155/2021/6406295
[47]  Wei, L., Gou, X., Su, B., Han, H., Guo, T., Liu, L., et al. (2022) Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis. Drug Design, Development and Therapy, 16, 2833-2850.
https://doi.org/10.2147/dddt.s351264
[48]  Chen, H., Xing, S., Wu, J., Li, Y., Yang, X., Wang, Z., et al. (2026) Zhichuanling Oral Liquid Attenuates Airway Inflammation in Asthma by Targeting the STIM1/CHOP/JNK Axis. Journal of Ethnopharmacology, 356, Article ID: 120859.
https://doi.org/10.1016/j.jep.2025.120859
[49]  Jiang, H., Bai, Z., Ou, Y., Liu, H., Si, Z., Liu, Y., et al. (2023) β-Hydroxybutyric Acid Upregulated by Suhuang Antitussive Capsule Ameliorates Cough Variant Asthma through GSK3β/AMPK-Nrf2 Signal Axis. Journal of Ethnopharmacology, 307, Article ID: 116013.
https://doi.org/10.1016/j.jep.2022.116013
[50]  Liu, B., Xiang, M., Zhou, M., Li, C., Xin, H., Zhang, S., et al. (2025) Pharmacological Effects and Mechanisms of Danlong Oral Liquid in Asthma Airway Remodeling: Insights from Serum Medicinal Chemistry, Network Pharmacology, and Experimental Validation. Journal of Ethnopharmacology, 340, Article ID: 119259.
https://doi.org/10.1016/j.jep.2024.119259
[51]  Kao, S., Wang, S., Lin, C. and Lin, L. (2018) Jin Gui Shen Qi Wan, a Traditional Chinese Medicine, Alleviated Allergic Airway Hypersensitivity and Inflammatory Cell Infiltration in a Chronic Asthma Mouse Model. Journal of Ethnopharmacology, 227, 181-190.
https://doi.org/10.1016/j.jep.2018.08.028
[52]  Yuan, J., Wang, Y., Sha, B., Zhang, Y., Mokuy, O.O.E.M., Jin, M., et al. (2025) Network Pharmacology and Experimental Validation of Inflammation Inhibition by Chuankezhi Injection in Treating Asthma. Phytomedicine, 143, Article ID: 156891.
https://doi.org/10.1016/j.phymed.2025.156891

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133