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双环[1.1.0]丁烷(BCBs)的不对称开环与异构化研究进展
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Abstract:
近几年，通过利用双环丁烷[1.1.0]释放环张力作为反应驱动力，继而与极性亲核试剂自由基等发生开环反应制备双环[n.1.1]烷烃的策略引起了材料化学、药物化学等领域学者的广泛关注。但是到目前为止还没有专门综述来探讨关于BCBs的不对称开环与异构化的研究进展。因此，本文按照催化体系的不同，对近几年关于BCBs的不对称开环与异构化的研究进展进行详细的综述。着重介绍了手性金属、手性Br？nsted酸等不同的催化方式在不对称开环与异构化反应中的应用情况，并对未来发展做出了展望。
In recent years, the strategy of utilizing the release of ring strain from bicyclo[1.1.0]butanes (BCBs) as a reaction driving force, followed by ring-opening reactions with polar nucleophiles, radicals, etc., to prepare bicyclo[n.1.1]alkanes has attracted widespread attention from researchers in fields such as materials chemistry and medicinal chemistry. However, to date, no dedicated review has addressed the research progress on the asymmetric ring-opening and isomerization of BCBs. Therefore, this review provides a detailed overview of recent advances in the asymmetric ring-opening and isomerization of BCBs, categorized by different catalytic systems. The applications of various catalytic approaches, including chiral metal catalysis and chiral Br？nsted acid catalysis, in asymmetric ring-opening and isomerization reactions are highlighted, and future perspectives in this field are also discussed.
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