Bisphenol A (BPA) is a synthetic chemical commonly found in thermal paper receipts, which are widely used in various sectors such as supermarkets, gas stations, and ATMs. BPA is known to have adverse effects on human health, including endocrine disruption, reproductive toxicity, neurobehavioral disorders, and carcinogenicity. This study aims to evaluate different extraction methods to identify the optimal ratio for recovering BPA from thermal paper receipts in the Saudi Arabian market. Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), we compared six extraction solutions: distilled water, distilled water/methanol (30:70), artificial acidic sweat/methanol (50:50), artificial alkaline sweat/methanol (50:50), artificial acidic sweat, and artificial alkaline sweat. Our findings indicate that the 30:70 distilled water/methanol and 50:50 artificial alkaline sweat/methanol solutions provided the highest BPA recovery, suggesting these ratios as the most effective for BPA extraction.
Reale, E., Vernez, D. and Hopf, N.B. (2020) Skin Absorption of Bisphenol A and Its Alternatives in Thermal Paper. AnnalsofWorkExposuresandHealth, 65, 206-218. https://doi.org/10.1093/annweh/wxaa095
[3]
Geens, T., Goeyens, L., Kannan, K., Neels, H. and Covaci, A. (2012) Levels of Bisphenol-A in Thermal Paper Receipts from Belgium and Estimation of Human Exposure. ScienceoftheTotalEnvironment, 435, 30-33. https://doi.org/10.1016/j.scitotenv.2012.07.001
[4]
Liao, C. and Kannan, K. (2011) Widespread Occurrence of Bisphenol a in Paper and Paper Products: Implications for Human Exposure. EnvironmentalScience&Technology, 45, 9372-9379. https://doi.org/10.1021/es202507f
[5]
Zalko, D., Jacques, C., Duplan, H., Bruel, S. and Perdu, E. (2011) Viable Skin Efficiently Absorbs and Metabolizes Bisphenol A. Chemosphere, 82, 424-430. https://doi.org/10.1016/j.chemosphere.2010.09.058
[6]
Biedermann, S., Tschudin, P. and Grob, K. (2010) Transfer of Bisphenol a from Thermal Printer Paper to the Skin. AnalyticalandBioanalyticalChemistry, 398, 571-576. https://doi.org/10.1007/s00216-010-3936-9
[7]
Koehler Paper (2026) The Structure of Conventional Thermal Paper. https://www.koehlerpaper.com/en/products/Thermal-paper/
[8]
BPC (UK) Ltd (2023) The Science behind Thermal Paper Rolls. https://bpcuk.com/the-science-behind-thermal-paper-rolls/
[9]
Human Exposure to Bisphenol A in Europe. https://www.eea.europa.eu/publications/peoples-exposure-to-bisphenol-a
[10]
Rochester, J.R. and Bolden, A.L. (2015) Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol a Substitutes. EnvironmentalHealthPerspectives, 123, 643-650. https://doi.org/10.1289/ehp.1408989
[11]
Björnsdotter, M.K., de Boer, J. and Ballesteros-Gómez, A. (2017) Bisphenol A and Replacements in Thermal Paper: A Review. Chemosphere, 182, 691-706. https://doi.org/10.1016/j.chemosphere.2017.05.070
[12]
Migeot, V., Dupuis, A., Cariot, A., Albouy-Llaty, M., Pierre, F. and Rabouan, S. (2013) Bisphenol A and Its Chlorinated Derivatives in Human Colostrum. EnvironmentalScience&Technology, 47, 13791-13797. https://doi.org/10.1021/es403071a
[13]
Ballesteros-Gómez, A., Rubio, S. and Pérez-Bendito, D. (2009) Analytical Methods for the Determination of Bisphenol a in Food. JournalofChromatographyA, 1216, 449-469. https://doi.org/10.1016/j.chroma.2008.06.037
[14]
Barroso, J. (2011) Commission Directive 2011/8/EU of 28 January 2011 Amending Directive 2002/72/EC as Regards the Restriction of Use of Bisphenol A in Plastic Infant Feeding Bottles. Official Journal of the European Union, 54, 11-14.
[15]
Geens, T., Aerts, D., Berthot, C., Bourguignon, J., Goeyens, L., Lecomte, P., et al. (2012) A Review of Dietary and Non-Dietary Exposure to Bisphenol-A. Food and Chemical Toxicology, 50, 3725-3740. https://doi.org/10.1016/j.fct.2012.07.059
[16]
Bisphenol A Market Analysis. https://www.chemanalyst.com/industry-report/bisphenol-a-market-57
[17]
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) (2015) Scientific Opinion on the Risks to Public Health Related to the Presence of Bisphenol a (BPA) in Foodstuffs. EFSA Journal, 13, 3978. https://doi.org/10.2903/j.efsa.2015.3978
[18]
Lu, S., Chang, W., Sojinu, S.O. and Ni, H. (2013) Bisphenol A in Supermarket Receipts and Its Exposure to Human in Shenzhen, China. Chemosphere, 92, 1190-1194. https://doi.org/10.1016/j.chemosphere.2013.01.096
[19]
Fan, R., Zeng, B., Liu, X., Chen, C., Zhuang, Q., Wang, Y., et al. (2015) Levels of Bisphenol-A in Different Paper Products in Guangzhou, China, and Assessment of Human Exposure via Dermal Contact. Environmental Science: Processes & Impacts, 17, 667-673. https://doi.org/10.1039/c4em00621f
[20]
Rocha, B.A., Azevedo, L.F., Gallimberti, M., Campiglia, A.D. and Barbosa, F. (2015) High Levels of Bisphenol a and Bisphenol S in Brazilian Thermal Paper Receipts and Estimation of Daily Exposure. Journal of Toxicology and Environmental Health, Part A, 78, 1181-1188. https://doi.org/10.1080/15287394.2015.1083519
[21]
Ehrlich, S., Calafat, A.M., Humblet, O., Smith, T. and Hauser, R. (2014) Handling of Thermal Receipts as a Source of Exposure to Bisphenol A. JAMA, 311, 859-860. https://doi.org/10.1001/jama.2013.283735
[22]
Lambré, C., Barat Baviera, J.M., Bolognesi, C., Chesson, A., Cocconcelli, P.S., Crebelli, R., et al. (2023) Re-Evaluation of the Risks to Public Health Related to the Presence of Bisphenol a (BPA) in Foodstuffs. EFSAJournal, 21, e06857. https://doi.org/10.2903/j.efsa.2023.6857
[23]
Semerjian, L., Alawadhi, N. and Nazer, K. (2023) Detection of Bisphenol a in Thermal Paper Receipts and Assessment of Human Exposure: A Case Study from Sharjah, United Arab Emirates. PLOSONE, 18, e0283675. https://doi.org/10.1371/journal.pone.0283675
[24]
Laaninen, T. (2018) New Rules on Bisphenol A in Food Contact Materials, At a Glance. https://www.europarl.europa.eu/RegData/etudes/ATAG/2018/614705/EPRS_ATA(2018)614705_EN.pdf
[25]
(2008) FDA Statement on Release of Bisphenol A (BPA) Subcommittee Report. https://www.sfda.gov.sa/en/awarenessarticle/897
[26]
Vinod, V., Amritha, P.S. and Harathi, P.B. (2023) A Systematic Review on Bisphenols—Sources, Health Impacts, and Analytical Determination of Bisphenol A in Aqueous Samples. SeparationSciencePlus, 6, Article ID: 2300072. https://doi.org/10.1002/sscp.202300072
[27]
Hormann, A.M., vom Saal, F.S., Nagel, S.C., Stahlhut, R.W., Moyer, C.L., Ellersieck, M.R., et al. (2014) Holding Thermal Receipt Paper and Eating Food after Using Hand Sanitizer Results in High Serum Bioactive and Urine Total Levels of Bisphenol a (BPA). PLOSONE, 9, e110509. https://doi.org/10.1371/journal.pone.0110509
[28]
Tian, H., Bai, X. and Xu, J. (2018) Extraction of Bisphenol A in Honey Samples Using Aqueous Biphasic Systems Coupled with High-Performance Liquid Chromatography. SeparationSciencePlus, 1, 374-381. https://doi.org/10.1002/sscp.201800019
[29]
Yalçin, M.S., Geçgel, C. and Battal, D. (2016) Determination of Bisphenol a in Thermal Paper Receipts. JournaloftheTurkishChemicalSociety, SectionA: Chemistry, 3, 167-174. https://doi.org/10.18596/jotcsa.21345
[30]
Eckardt, M. and Simat, T.J. (2017) Bisphenol A and Alternatives in Thermal Paper Receipts—A German Market Analysis from 2015 to 2017. Chemosphere, 186, 1016-1025. https://doi.org/10.1016/j.chemosphere.2017.08.037
[31]
Russo, G., Barbato, F. and Grumetto, L. (2017) Monitoring of Bisphenol a and Bisphenol S in Thermal Paper Receipts from the Italian Market and Estimated Transdermal Human Intake: A Pilot Study. ScienceoftheTotalEnvironment, 599, 68-75. https://doi.org/10.1016/j.scitotenv.2017.04.192
[32]
International Organization for Standardization ISO (2017) ISO/IEC 17025 General Requirements for the Competence of Testing and Calibration Laboratories. 3rd Edition, Geneva.
[33]
Technical Regulation for Paper and Cardboard, SASO’s Board of Directors No. (181). https://www.saso.gov.sa/en/Laws-And-Regulations/Technical_regulations/Documents/TR-Paper-and-Cardboard.pdf
[34]
Park, S., Park, S., Jeong, M., Choi, J.C. and Kim, M. (2018) Fast and Simple Determination and Exposure Assessment of Bisphenol A, Phenol, P-Tert-Butylphenol, and Diphenylcarbonate Transferred from Polycarbonate Food-Contact Materials to Food Simulants. Chemosphere, 203, 300-306. https://doi.org/10.1016/j.chemosphere.2018.03.185
[35]
Khan, M.R., Alammari, A.M., Aqel, A. and Azam, M. (2021) Trace Analysis of Environmental Endocrine Disrupting Contaminant Bisphenol a in Canned, Glass and Polyethylene Terephthalate Plastic Carbonated Beverages of Diverse Flavors and Origin. FoodScienceandTechnology, 41, 210-217. https://doi.org/10.1590/fst.03420
[36]
Sungur, Ş., Köroğlu, M. and Özkan, A. (2014) Determination of Bisphenol a Migrating from Canned Food and Beverages in Markets. FoodChemistry, 142, 87-91. https://doi.org/10.1016/j.foodchem.2013.07.034
[37]
Vilarinho, F., Sendón, R., van der Kellen, A., Vaz, M.F. and Silva, A.S. (2019) Bisphenol A in Food as a Result of Its Migration from Food Packaging. TrendsinFoodScience&Technology, 91, 33-65. https://doi.org/10.1016/j.tifs.2019.06.012
[38]
Vinković, K., Vukoje, M., Rožić, M. and Galić, N. (2019) Migration of Pseudoestrogen Bisphenol a from Various Types of Paper with Thermochromic Prints to Artificial Sweat Solutions. JournalofLiquidChromatography&RelatedTechnologies, 43, 195-202. https://doi.org/10.1080/10826076.2019.1704775
[39]
Salkind, N. (2010) Encyclopedia of Research Design. SAGE Publications, Inc.
