Tuberculous diaphyseal osteitis of the tibia is rare in adults. We report a case of a 26-year-old female patient with sickle cell anemia SS. Physical examination revealed swelling of the left leg in the middle third. Laboratory tests revealed a systemic inflammatory response syndrome. Imaging showed endomedullary osteolytic lesions of the tibial diaphysis. Pathological examination concluded that tibial resection was required, revealing case-follicular tuberculosis, which was bone tuberculosis. Medical treatment was administered to the patient. At 15 months of follow-up, the examination revealed complete healing of the wound. Diaphyseal tuberculous osteitis of the tibia is rare, and its association with sickle cell anemia SS has not yet been described in the literature.
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