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训练免疫：糖尿病与牙周炎的潜在机制联系
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Abstract:
糖尿病高血糖可诱导髓系细胞发生持久的代谢与表观遗传重编程，形成促炎记忆状态，使免疫细胞在后续刺激中反应增强。即使血糖得到控制，此类免疫记忆仍持续存在，导致牙周炎症加剧、组织破坏加重。靶向训练免疫机制，为防治糖尿病相关牙周炎提供了新的潜在策略。
Hyperglycemia induces persistent metabolic and epigenetic reprogramming in myeloid cells, establishing a pro-inflammatory memory state that enhances immune cell responses to subsequent stimuli. Even after glycemic control is achieved, this immune memory persists, leading to exacerbated periodontal inflammation and increased tissue destruction. Targeting the mechanisms of trained immunity offers new potential strategies for the prevention and treatment of diabetes-associated periodontitis.
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