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光诱导的自由基脱氰反应研究进展
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Abstract:
脱氰基是药物研究、医学和材料科学研究中芳香分子合成的重要过程。在过去几十年中，由于氰基的热力学稳定性，很少有人将其认为是一个好的反应位点。随着科学技术的进步，光化学反应发展迅速，凭借其绿色、可持续、高效降解等优势，正日益成为环境修复领域的研究热点。近些年来，化学中备受争议的氰基转化问题也在光化学中取得了重大进展。本文综述了通过可见光介导的氰基作为离去基团的芳基自由基脱氰反应研究最新进展。
Decyanation is an important process in the synthesis of aromatic molecules in drug research, medicine, and materials science. In the past few decades, due to the thermodynamic stability of the CN, it has rarely been considered a favorable reaction site. With advances in science and technology, photochemical reactions have developed rapidly, and thanks to their advantages such as being green, sustainable, and highly efficient in degradation, they are increasingly becoming a research hotspot in the field of environmental remediation. In recent years, the long-debated issue of cyano group transformation in chemistry has also seen significant progress in photochemistry. This article reviews the latest developments in the study of visible-light-mediated aryl radical decyanation reactions using CN as leaving groups.
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