Objective: To clinically analyze the clinical characteristics and risk factors of patients with pulmonary tuberculosis complicated by venous thromboembolism. Methods: A total of 80 patients with complete data, diagnosed with pulmonary tuberculosis complicated by venous thromboembolism, who were hospitalized at the Fourth People’s Hospital of the Autonomous Region from May 2018 to September 2023, were selected as the observation group. Another 80 patients with simple pulmonary tuberculosis were selected as the control group. The basic information of the two groups was compared, and the risk factors for pulmonary tuberculosis complicated by venous thromboembolism were analyzed. Results: There were significant differences (P < 0.05) between the observation group and the control group regarding age, D-dimer, fibrinogen, fibrin degradation products, platelet count, albumin, total protein, bed rest (>3 days), recent surgery/trauma history, and diabetes. Regarding indicators related to the severity of pulmonary tuberculosis, the incidence rates of multi-lobar involvement, cavity formation, and hypoxemia in the observation group were significantly higher than those in the control group (P < 0.05). Age, D-dimer, fibrinogen, fibrin degradation products, platelet count, bed rest (>3 days), and diabetes were risk factors for pulmonary tuberculosis complicated by venous thromboembolism. Conclusion: The independent risk factors for pulmonary tuberculosis complicated by venous thromboembolism include age, D-dimer, fibrinogen, fibrin degradation products, platelet count, bed rest (>3 days), and diabetes.
References
[1]
Shao, X., Si, C.Z., Zhen, K.Y., et al. (2020) Clinical Characteristics and Associated Risk Factors of Hospital-Associated Venous Thromboembolism. ChineseMedicalJournal, 100, 1539-1543.
[2]
Wang, H., Zou, Q.Y. and Guo, Y.J. (2023) Analysis of Risk Factors and Preventive Measures for Venous Thromboembolism in Lung Cancer Patients Receiving Chemotherapy. JournalofPracticalCancer, 38, 1526-1528.
[3]
Cao, A., Nie, Y., Zhong, Z., Pei, Y., Deng, P., Xie, H., et al. (2025) Predictive Analysis of All-Cause Mortality of Previously Untreated Pulmonary Tuberculosis Patients Complicated by Hypertension. FrontiersinCellularandInfectionMicrobiology, 15, Article ID: 1574824. https://doi.org/10.3389/fcimb.2025.1574824
[4]
Shi, C.J., Li, L.F., Li, W.M., et al. (2025) The Value of the Plate-Let-to-Lymphocyte Ratio, the Red Cell Distribution Width-to-Albumin Ratio, and the Systemic Immune-Inflammation Index in Assessing High-Risk Venous Thromboembolism in Patients with Pulmonary Tuberculosis. ChineseJournalofTropicalMedicine, 25, 1181-1186.
[5]
Yang, Q. and Liu, Q.Y. (2025) Analysis of Risk Factors for the Occurrence of Lower Extremity Deep Vein Thrombosis in Elderly Patients with Pulmonary Tuberculosis. ChineseJournalofGeriatricMedicine, 44, 772-775.
[6]
Luo, T.R. and Sun, N.N. (2023) A Case Report of Rifampicin Combined with Edoxaban for the Treatment of Pulmonary Tuberculosis Complicated by Deep Vein Thrombosis. ElectronicJournalofEmergingInfectiousDiseases, 8, 69-72.
[7]
Shi, C.J., Li, W.M., Luo, Y., et al. (2025) Value of Assessing the Risk of Venous Thromboembolism in Patients with Pulmonary Tuberculosis Using a Lasso-Logistic Regression Model Fitted with NRS 2002 Score, CONUT Score, and RDW-SD and ALB. JournalofKunmingMedicalUniversity, 46, 33-42.
[8]
Desai, U., Utpat, K., Agarwal, K. and Samuel, M. (2025) A Case of Lung Cancer with Venous Thromboembolism with Pre-Extensively Drug-Resistant Pulmonary Tuberculosis: A Rare Triad. MedicalJournalofDr. D.Y. PatilVidyapeeth, 18, 145-147. https://doi.org/10.4103/mjdrdypu.mjdrdypu_932_23
[9]
Mu, Q., Li, J.J., Wang, Z., et al. (2023) Value of Combined D-Dimer and Caprini Score in the Diagnosis of Venous Thromboembolism in Elderly Patients with Pulmonary Infection. ChineseJournalofPracticalDiagnosisandTherapy, 37, 284-287.
[10]
Danwang, C., Bigna, J.J., Awana, A.P., Nzalie, R.N. and Robert, A. (2020) Global Epidemiology of Venous Thromboembolism in People with Active Tuberculosis: A Systematic Review and Meta-Analysis. JournalofThrombosisandThrombolysis, 51, 502-512. https://doi.org/10.1007/s11239-020-02211-7
[11]
Zhao, Y.L., Yi, D., Zhang, L., Geng, X.X. and Ye, H. (2025) Analysis of Factors Influencing Central Venous Catheter-Related Thrombosis in Patients with Severe Pulmonary Tuberculosis. BeijingMedicine, 47, 33-36.
[12]
Wang, Z.N., An, X.L., Liu, L.Y., et al. (2022) Predictive Value of Peripheral Blood Angiotensin II, Ischemia-Modified Albumin, and C-Reactive Protein for Venous Thrombo-Embolism. ChineseJournalofArteriosclerosis, 30, 705-708.
[13]
Ji, X., Zhu, P., Huang, S.D., et al. (2025) A Retrospective Analysis of Risk Factors for Venous Thromboembolism in Hospitalized Patients with Autoimmune Bullous Diseases. ChineseJournalofDermatology, 58, E6-E10.
[14]
Li, G., Wang, C.L., Ma, L., et al. (2024) Correlation Analysis of the Padua Score and Serum vWF and IMA Levels with the Occurrence of Venous Thromboembolism in Patients with Septic Shock. JournalofClinicalEmergency, 25, 246-250.
[15]
Yang, F., Yu, X.L., Chen, Y., et al. (2022) Clinical Analysis of Tuberculosis Complicated by Pulmonary Thromboembolism. ContemporaryMedicine, 28, 133-135.
