Background: Sickle cell disease (SCD) is a genetic condition highly prevalent among the Black population, with serious consequences for the daily lives of those affected. Objective: To study the impact of SCD on the professional and social experiences of workers with SCD monitored at Saint Camille Hospital in Ouagadougou in 2023. Materials andMethods: This was a descriptive cross-sectional study with data collection through questionnaires administered to adult workers with sickle cell disease who were regularly followed up on the active roster at Saint Camille Hospital in Ouagadougou. Results: We conducted interviews with 146 workers with SCD. Females were the most represented, accounting for 54.42%. The most commonly observed level of education was secondary education. The public sector was the most represented employment sector, with 33.82%. Vaso-occlusive crises were the most frequent recurrent clinical manifestation, at 27.97%, and chronic complications accounted for 21.97% of cases. Workers with sickle cell disease were absent from work an average of 3.75 days ± 3.63 days during crises. Eighty-four point thirty-five percent (84.35%) received emotional support from friends and extended family, while 38.69% did not participate in social association activities. Conclusion: Sickle cell disease influences the social and professional lives of workers. The establishment of a health policy within public and private companies, combined with proper management of the condition, would ensure the full well-being of these individuals.
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