Effect of Exercise Training Combined with Galantamine on Neurological Function and Muscle Strength Recovery in Patients with Hemiplegia after Acute Ischemic Stroke
Objective: To analyze the effect of exercise training combined with galantamine hydrobromide injection on the neurological and motor function of patients with hemiplegia after acute ischemic stroke. Methods: A total of 100 patients with acute ischemic stroke admitted to the Department of Neurology of our hospital from April 2025 to February 2026 were selected as the study subjects. According to the intervention protocol, they were divided into an observation group (50 cases receiving galantamine + conventional treatment + exercise training) and a control group (50 cases receiving conventional treatment + exercise training). General clinical data were collected from both groups, and assessments were performed before and after intervention using the National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS), and Manual Muscle Test (MMT). Results: There were no statistically significant differences in gender, age, TOAST classification, or disease course between the observation group and the control group of patients with acute ischemic stroke hemiplegia (P > 0.05). Compared between the observation group and the control group, the MMT values were significantly higher after treatment than before, with statistically significant differences (P < 0.001), while no statistically significant difference was observed between the two groups (P > 0.05). After treatment, the mRS scores and NIHSS scores in both groups decreased significantly compared to pre-treatment levels (P < 0.001), with the observation group showing significantly lower scores than the control group (P < 0.001). No statistically significant difference was observed in upper limb muscle strength efficacy between the two groups (χ2 = 5.93, P > 0.05), whereas a statistically significant difference was noted in lower limb muscle strength efficacy (χ2 = 16.07, P < 0.001). The efficacy rate of the observation group (54.00%) was significantly higher than that of the control group (16.00%). Pairwise comparisons revealed statistically significant differences in the efficacy rates of lower limb muscle strength between the two groups (P < 0.05). Conclusion: Galantamine combined with exercise training can promote the recovery of neurological function and muscle strength in patients with acute ischemic stroke, improve the ability of daily living activities.
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