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Antidiabetic and Pancreato-Hepato-Renal Protective Effects of Entada africana (Fabaceae) Stem Bark Aqueous Extract in Fructose/Sucrose and Streptozotocin-Induced Type 2 Diabetic Rat

DOI: 10.4236/pp.2026.172005, PP. 75-106

Keywords: Fructose/Sucrose/Streptozotocin, Type 2 Diabetes, Entada africana, Safe, Insulin Sensitizing, Antihyperglycemic, Antidiabetic, Antioxidant, Hepatoprotective, Nephroprotective, Pancreatoprotective, Rat

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Abstract:

Background: Type 2 diabetes mellitus is a growing public health problem that can lead to multi-organ damage. This study assessed the antidiabetic and antioxidant effects of Entada africana stem bark aqueous extract on pancreatic, hepatic, and renal damage in type 2 diabetic rats. Methods: Qualitative phytochemical analyses and acute toxicity assessment of the extract were performed. Normal Wistar rats underwent oral glucose tolerance tests after single (75 - 300 mg/kg) and 28-day (300 mg/kg) pretreatment with the extract, and fasting blood glucose was monitored for 2.5 h. Type 2 diabetes was induced in other rats by administering 10% fructose by gavage and 10% sucrose in drinking water for 21 days, followed by streptozotocin (40 mg/kg; i.p.) injections on days 22 and 57. Diabetic rats received daily doses (75 - 300 mg/kg) of the extract for 28 days. Body weight and non-fasting blood glucose were measured before treatment and weekly thereafter, and insulin sensitivity, serum and tissue biochemical, and histological parameters were assessed at the end. Glibenclamide (10 mg/kg) served as the standard. Results: E. africana stem bark aqueous extract contains mucilage, cardiac glycosides, reducing sugars, unsaturated sterols, free quinones, saponins, polyphenols, flavones, flavonols, gallic tannins and triterpenoids, and exhibited low toxicity. The extract (300 mg/kg) improved glucose tolerance (p < 0.05) after 28 days in normal rats. In diabetic rats, it significantly (p < 0.05-p < 0.001) improved blood glucose, insulin sensitivity, lipid profile, and atherogenic risk index; reduced serum ALT, AST, ALP, Bilirubin, Urea, Uric acid, and Creatinine; and increased liver glycogen, albumin and total protein levels. It also decreased MDA and increased SOD, CAT, and GSH levels in the liver, kidneys and pancreas, improving their integrity. Conclusion: The safety, antihyperglycemic, insulin-sensitizing, lipid-modifying, and antioxidant activities, along with pancreato-, hepato-, and nephroprotective effects of E. africana stem bark aqueous extract, likely mediated by its phytoconstituents, justify its traditional medicinal use.

 References

[1]  Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. (2004) Global Prevalence of Diabetes: Estimates for the Year 2000 and Projection for 2030. Diabetes Care, 27, 1047-1053.
https://doi.org/10.2337/diacare.27.5.1047
[2]  World Health Organization (WHO) (2016) Global Report on Diabetes. World Health Organization, Geneva. 88p.
http://apps.who.int/iris/bitstream/10665/204871/1/9789241565257_eng.pdf?ua=1
[3]  International Diabetes Federation (IDF) (2021) IDF Diabetes Atlas. 10th Edition, IDF, 135 p.
https://www.diabetesatlas.org
[4]  Wordl Health Organisation (WHO) (2024) Urgent Action Needed as Global Diabetes Cases Increase Four-Fold over Past Decades.
[5]  Assou, C., Anago, E., Senou, M., Agbogba, F., Agniwo, P., Lokonon, J.E., et al. (2022) Anti-Hyperglycemic Effect of Momordica charantia Green Fruit Extract. International Journal of Pharmaceutical Science Invention, 11, 6-16.
[6]  Kahou Bi, G.P., Claude Abo, K.J. and Irie Bi, J.S. (2016) Effet D’un Extrait Aqueux de Pseudarthria Hookeri Wight & Arn. (Fabaceae) sur la Glycemie et sur la Liberation et le Stockage du Glucose Hepatique de Rats Diabetiques. European Scientific Journal, ESJ, 12, 37-47.
https://doi.org/10.19044/esj.2016.v12n6p37
[7]  Omodanisi, E.I., Aboua, Y.G., Chegou, N.N. and Oguntibeju, O.O. (2017) Hepatoprotective, Antihyperlipidemic, and Anti-Inflammatory Activity of Moringa oleifera in Diabetic-Induced Damage in Male Wistar Rats. Pharmacognosy Research, 9, 182-187.
[8]  Tangvarasittichai, S. (2015) Oxidative Stress, Insulin Resistance, Dyslipidemia and Type 2 Diabetes Mellitus. World Journal of Diabetes, 6, 456-480.
https://doi.org/10.4239/wjd.v6.i3.456
[9]  Claire Tchamadeu, M., Yefou Tsangue, R., Zangue Bogning, C., Takoukam Ténézoguang, C., Emambo, P., Désiré Djomeni Dzeufiet, P., et al. (2022) Pterocarpus soyauxii Taub (Papilionaceae) Aqueous Stem Bark Extract Prevents Dexamethasone-Induced Insulin Resistance and Oxidative Stress in Rat. Journal of Diseases and Medicinal Plants, 8, 1-12.
https://doi.org/10.11648/j.jdmp.20220801.11
[10]  Caturano, A., D’Angelo, M., Mormone, A., Russo, V., Mollica, M.P., Salvatore, T., et al. (2023) Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications. Current Issues in Molecular Biology, 45, 6651-6666.
https://doi.org/10.3390/cimb45080420
[11]  Chen, X., Xie, N., Feng, L., Huang, Y., Wu, Y., Zhu, H., et al. (2024) Oxidative Stress in Diabetes Mellitus and Its Complications: From Pathophysiology to Therapeutic Strategies. Chinese Medical Journal, 138, 15-27.
https://doi.org/10.1097/cm9.0000000000003230
[12]  Diarra, B. (2011) Effets de l’administration répétée du décocté des racines de Entada africana Guill & Perr (Mimosaceae) sur certains paramètres biologiques chez les rats. Thèse de doctorat, Université de Bamako, 126 p.
https://www.bibliosante.ml/handle/123456789/1863
[13]  Mbatchou, V.C., Ayebila, A.J. and Apea, O.B. (2011) Antibacterial Activity of Phyto-chemicals from Acacia nilotica, Entada africana and Mimosa pigra L. on Salmonella typhi. Journal of Animal and Plant Sciences, 10, 1248-1258.
[14]  Yusuf, A.J. and Abdullahi, M.I. (2019) The Phytochemical and Pharmacological Actions of Entada africana Guill. & Perr. Heliyon, 5, e02332.
https://doi.org/10.1016/j.heliyon.2019.e02332
[15]  Paul, O.L., Saoudia, D.W.F., et al. (2022) Phytochemical Screening, Phenolic Content and Antioxidant Activity of Entada africana and Sterculia stigera Two Plants Used in the Treatment of Cough. Journal of Applied Biosciences, 178, 18658-18669.
[16]  Onikanni, S.A., Lawal, B., Munyembaraga, V., Bakare, O.S., Taher, M., Khotib, J., et al. (2023) Profiling the Antidiabetic Potential of Compounds Identified from Fractionated Extracts of Entada africana toward Glucokinase Stimulation: Computational Insight. Molecules, 28, Article 5752.
https://doi.org/10.3390/molecules28155752
[17]  Abulude, F.O., Adesanya, W.O. and Afowowe, F.M. (2014) Phytochemical Screening of the Root, Bark, and Leaves of Flamboyant Tree in Nigeria. Continental Journal of Biomedical Sciences, 8, 12-21.
[18]  Trease, G.E. and Evans, W.C. (1989) Trease and Evan’s Textbook of Pharmacognosy. 13th Edition, Cambridge University Press, 546 p.
[19]  Kokate, C.K. (2014) Practical Pharmacognosy. 5th Edition, Vallabh Prakashan.
[20]  Gülçin, İ., Alici, H.A. and Cesur, M. (2005) Determination of in Vitro Antioxidant and Radical Scavenging Activities of Propofol. Chemical and Pharmaceutical Bulletin, 53, 281-285.
https://doi.org/10.1248/cpb.53.281
[21]  Dohou, N., Yamni, K., Tahrouch, S., Idrissi Hassani, L.M., Badoc, A. and Gmira, N. (2003) Screening phytochimique d’une endémique ibéro-marocaine, Thymelaea lythroides. Bulletin de la Société Pharmaceutique de Bordeaux, 142, 61-78.
https://www.researchgate.net/publication/285309509_Screening_phytochimique_d’une_endemique_ibero-marocaine_Thymelaea_lythroides#fullTextFileContent
[22]  Organisation for Economic Co-Operation and Development (OECD) (2022) OECD Guideline for the Testing of Chemicals. Acute oral Toxicity—Up-and-Down-Procedure (UDP), 29 p.
[23]  Wilson, R.D. and Islam, M.S. (2012) Fructose-Fed Streptozotocin-Injected Rat: An Alternative Model for Type 2 Diabetes. Pharmacological Reports, 64, 129-139.
https://doi.org/10.1016/s1734-1140(12)70739-9
[24]  George, L., Bacha, F., Lee, S., Tfayli, H., Andreatta, E. and Arslanian, S. (2011) Surrogate Estimates of Insulin Sensitivity in Obese Youth along the Spectrum of Glucose Tolerance from Normal to Prediabetes to Diabetes. The Journal of Clinical Endocrinology & Metabolism, 96, 2136-2145.
https://doi.org/10.1210/jc.2010-2813
[25]  Reignier, A., Sacchetto, É., Hardouin, J., Orsonneau, J., Le Carrer, D., Delaroche, O., et al. (2014) Comparison of Calculated LDL Cholesterol (LDL-C) versus Measured LDL Cholesterol (LDL-M) and Potential Impact in Terms of Therapeutic Management. Annales de biologie clinique, 72, 593-598.
https://doi.org/10.1684/abc.2014.0990
[26]  McLaughlin, T., Reaven, G., Abbasi, F., Lamendola, C., Saad, M., Waters, D., et al. (2005) Is There a Simple Way to Identify Insulin-Resistant Individuals at Increased Risk of Cardiovascular Disease? The American Journal of Cardiology, 96, 399-404.
https://doi.org/10.1016/j.amjcard.2005.03.085
[27]  Wilbur, K.M., Bernhein, F. and Shapiro, O.W. (1949) The Thiobarbituric Acid Reagent as a Test for the Oxidation of Unsaturated Fatty Acids by Various Agents. Archives of Biochemistry, 24, 305-313.
[28]  Ellman, G.L. (1959) Tissue Sulfhydryl Groups. Archives of Biochemistry and Biophysics, 82, 70-77.
https://doi.org/10.1016/0003-9861(59)90090-6
[29]  Sinha, A.K. (1972) Colorimetric Assay of Catalase. Analytical Biochemistry, 47, 389-394.
https://doi.org/10.1016/0003-2697(72)90132-7
[30]  Tarabishy, A.B., Aldabagh, B., Sun, Y., Imamura, Y., Mukherjee, P.K., Lass, J.H., et al. (2008) MYD88 Regulation of Fusarium Keratitis Is Dependent on TLR4 and IL-1R1 but Not TLR2. The Journal of Immunology, 181, 593-600.
https://doi.org/10.4049/jimmunol.181.1.593
[31]  Scheen, A.J. (2019) Type 2 Diabetes Mellitus: An Overview of Pathophysiology, Clinical Features, and Treatments. Acta Clinica Belgica, 74, 168-174.
[32]  Powers, A.C. and D’Alessio, D. (2020) Chapter 39: Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology. In: Melmed, S., Koenig, R., Rosen, C.J., Auchus, R.J. and Goldfine, A.B., Eds., Williams Textbook of Endocrinology (14th Edition), Elsevier, 1362-1392.
[33]  American Diabetes Association (ADA) (2024) Standards of Care in Diabetes-2024. Diabetes Care, 47, S1-S305.
[34]  Tibiri, A., Rakotonandrasna, O., Nacoulma, G. and Banzouzi, J. (2007) Radical Scavenging Activity, Phenolic Content and Cytotoxicity of Bark and Leaves Extracts of Entada africana Guill. and Perr. (Mimosaceae). Journal of Biological Sciences, 7, 959-963.
https://doi.org/10.3923/jbs.2007.959.963
[35]  Tibiri, A., Sawadog, R.W. and Ouedraogo, N. (2010) Evaluation of Antioxidant Activity, Total Phenolic and Flavonoid Contents of Entada africana Guill. et Perr. (Mimosaceae) Organ Extracts. Research Journal of Medical Sciences, 4, 81-87.
https://doi.org/10.3923/rjmsci.2010.81.87
[36]  Njayou, F.N., Aboudi, E.C.E., Tandjang, M.K., Tchana, A.K., Ngadjui, B.T. and Moundipa, P.F. (2013) Hepatoprotective and Antioxidant Activities of Stem Bark Ex-tract of Khaya grandifoliola (Welw) CDC and Entada africana Guill. et Perr. Journal of Natural Products, 6, 73-80.
[37]  Ifemeje, J., Egbuna, C., Udedi, S. and Iheukwumere, H. (2014) Phytochemical and in Vitro Antibacterial Evaluation of the Ethanolic Extract of the Stem Bark of Entada africana Guill. & Perr and Sarcocephalus latifolus. International Journal of Biochemistry Research & Review, 4, 584-592.
https://doi.org/10.9734/ijbcrr/2014/11554
[38]  Njayou, F.N., Amougou, A.M., Fouemene Tsayem, R., Njikam Manjia, J., Rudraiah, S., Bradley, B., et al. (2015) Antioxidant Fractions of Khaya grandifoliola C.DC. and Entada africana Guill. et Perr. Induce Nuclear Translocation of NRF2 in HC-04 Cells. Cell Stress and Chaperones, 20, 991-1000.
https://doi.org/10.1007/s12192-015-0628-6
[39]  Kwaji, A., Adamu, H. and Chindo, I. (2017) Phytochemical Analysis, Antibacterial and Antioxidant Activities of Entada africana Guill. and Perr. Stem Bark Extracts. Journal of Chemical Sciences, 7, 10-15.
[40]  Baidoo, M.F., Asante-Kwatia, E., Mensah, A.Y., Sam, G.H. and Amponsah, I.K. (2019) Pharmacognostic Characterization and Development of Standardization Parameters for the Quality Control of Entada africana Guill. & Perr. Journal of Applied Research on Medicinal and Aromatic Plants, 12, 36-42.
https://doi.org/10.1016/j.jarmap.2018.11.003
[41]  Hassan, L.G., Mshelia, H.E., Umar, K.J., Kangiwa, S.M., Ogbiko, C. and Yusuf, A.J. (2018) Phytochemical Screening, Isolation and Characterization of β-Sitosterol from Ethylacetate Extract of Stem Bark of Entada africana (Fabaceae) Guill. et Perr. Journal of Chemical Society of Nigeria, 43, 540-546.
[42]  Tibiri, A., Banzouzi, J.T., Traore, A., Nacoulma, G.O., Guissou, I.P. and Mbatchi, B. (2007) Toxicological Assessment of Methanolic Stem Bark and Leaf Extracts of Entada africana Guill. and Perr., Mimosaceae. International Journal of Pharmacology, 3, 393-399.
https://doi.org/10.3923/ijp.2007.393.399
[43]  Hassan, L.G., Mshelia, H.E., Umar, K.J., Kangiwa, S.M., Ogbiko, C. and Yusuf, A.J. (2017) Analgesic Activity and Toxicity Profile of the Ethylacetate Extract of the Stem Bark of Entada africana (Fabaceae) Guill. et Perr. Asuu Journal of Science, A Journal of Research and Development, 4, 114-121.
[44]  Tenezogang, T.C., Tchamadeu, M.C., Bogning, Z.C., Emambo, P., Wankeu, N.M., Dongmo, A.B., et al. (2022) Maternal-Fetal Repercussions of Angylocalyx Oligophyllus Leaves Aqueous Extract in Pregnant Rat. African Journal of Pharmacy and Pharmacology, 16, 143-152.
https://doi.org/10.5897/ajpp2021.5317
[45]  Emambo, P., Tchamadeu, M.C., Ebanda, P.B., Takoukam, C.T., Wankeu, M.N., Dongmo, A.B., et al. (2022) Acute and Sub-Chronic Toxicity Study of Artabotrys aurantiacus Engl (Annonaceae) Leaves Aqueous Extract in Rat. International Journal of Biosciences, 21, 24-36.
[46]  Pechi, K.A.F., Bogning, C.Z., Longo, F., Tchamadeu, M.C., Tenezogang, C.T. and Dongmo, A.B. (2024) Acute and Sub-Acute Oral Toxicity Studies of Artabotrys thomsonii Oliv (Annonaceae) Leaves Aqueous Extract in Wistar Rat. International Journal of Pharmaceutical Sciences and Research, 15, 1000-1014.
[47]  Moini, J. (2019) Diagnosis. In: Jahangir, M., Ed., Epidemiology of Diabetes, Elsevier, 153-161.
https://doi.org/10.1016/b978-0-12-816864-6.00010-9
[48]  Tripathi, P., Kadam, N., Tiwari, D., Vyawahare, A., Sharma, B., Kathrikolly, T., et al. (2024) Correction: Oral Glucose Tolerance Test Clearance in Type 2 Diabetes Patients Who Underwent Remission Following Intense Lifestyle Modification: A Quasi-Experimental Study. PLOS ONE, 19, e0315024.
https://doi.org/10.1371/journal.pone.0315024
[49]  Liu, K., Niu, C., Tsai, J., Yang, C., Peng, W. and Niu, H. (2020) Comparison of Area under the Curve in Various Models of Diabetic Rats Receiving Chronic Medication. Archives of Medical Science, 18, 1078-1087.
https://doi.org/10.5114/aoms.2019.91471
[50]  Tchamadeu, M.C., Ndame, H.E., Bogning, C.Z., Wankeu-Nya, M., Emambo, P., Fonga, O.S., et al. (2023) Acute and Prolonged Effects of a Polyherbal Formulation on Blood Glucose, Lipid Profile and Liver Function in Normal and Streptozotocin-Induced Diabetic Rats. Journal of Biosciences and Medicines, 11, 277-302.
https://doi.org/10.4236/jbm.2023.1111024
[51]  Barragán-Bonilla, M.I., Mendoza-Bello, J.M., Aguilera, P., Parra-Rojas, I., Illades-Aguiar, B., Ramírez, M., et al. (2019) Combined Administration of Streptozotocin and Sucrose Accelerates the Appearance of Type 2 Diabetes Symptoms in Rats. Journal of Diabetes Research, 2019, Article ID: 3791061.
https://doi.org/10.1155/2019/3791061
[52]  Olatunji, O.J., Zuo, J. and Olatunde, O.O. (2021) Securidaca inappendiculata Stem Extract Confers Robust Antioxidant and Antidiabetic Effects against High Fructose/Streptozotocin Induced Type 2 Diabetes in Rats. Exploration of Bioactive Compounds Using UHPLC-ESI-QTOF-MS. Archives of Physiology and Biochemistry, 129, 1187-1199.
https://doi.org/10.1080/13813455.2021.1921811
[53]  Kevin-Armel, F.P., Marie, C.T., Frida, L., Calvin, Z.B., Patience, E., Ronald, K.T.K., et al. (2025) Pharmacological Effects of the Aqueous Extract from the Leaves of Artabotrys thomsonii Oliv. (Annonaceae) against Diabetic Hypertension Induced by Fructose/Sucrose and Streptozotocin (STZ) in Wistar Rats. Journal of Medicinal Plants Research, 19, 92-105.
https://doi.org/10.5897/jmpr2025.7405
[54]  Aeberli, I., Hochuli, M., Gerber, P.A., Sze, L., Murer, S.B., Tappy, L., et al. (2012) Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men: A Randomized Controlled Trial. Diabetes Care, 36, 150-156.
https://doi.org/10.2337/dc12-0540
[55]  Jauzein, F. (2019) Le fructose: Bénéfices et risques.
https://planet-vie.ens.fr/thematiques/sante/le-fructose-benefices-et-risques#:~:text=Lefructoseaunpouvoir,faible%2Cde0%2C7
[56]  Li, Y., Soos, T.J., Li, X., Wu, J., DeGennaro, M., Sun, X., et al. (2004) Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101. Journal of Biological Chemistry, 279, 45304-45307.
https://doi.org/10.1074/jbc.c400186200
[57]  Marion, H. (2011) Obésité et insulinorésistance: Étude longitudinale avec un traceur du transport du glucose, le [125l]-6-déoxy-6-iodo-d-glucose. Thèse de doctorat, Université de Grenoble, 171 p.
[58]  Jornayvaz, F.R. and Shulman, G.I. (2012) Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance. Cell Metabolism, 15, 574-584.
https://doi.org/10.1016/j.cmet.2012.03.005
[59]  Boyer, F. (2016) Stress oxydant et pathologie diabétique: Impact de l’hyperglycémie et de l’albumine glyquée sur les cellules cardiaques et adipeuses. Thèse de doctorat, Université de la Réunion.
https://theses.hal.science/tel-01379536v1
[60]  DiNicolantonio, J.J., Lucan, S.C. and O’Keefe, J.H. (2016) The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease. Progress in Cardiovascular Diseases, 58, 464-472.
https://doi.org/10.1016/j.pcad.2015.11.006
[61]  Woo, J.R., Bae, S., Wales, T.E., Engen, J.R., Lee, J., Jang, H., et al. (2024) The Serine Phosphorylations in the IRS-1 PIR Domain Abrogate IRS-1 and IR Interaction. Proceedings of the National Academy of Sciences of the United States of America, 121, e2401716121.
https://doi.org/10.1073/pnas.2401716121
[62]  Nahdi, A.M.T.A., John, A. and Raza, H. (2017) Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5f Pancreatic β‐cells. Oxidative Medicine and Cellular Longevity, 2017, Article ID: 7054272.
https://doi.org/10.1155/2017/7054272
[63]  Akirav, E., Lebendiker, M. and Le, A. (2020) Animal Models of Diabetes: A Comparative Review of Type 1 and Type 2 Diabetes Models. Biomed Research International, 2020, Article ID: 819065.
[64]  Ayua, E.O., Nkhata, S.G., Namaumbo, S.J., Kamau, E.H., Ngoma, T.N. and Aduol, K.O. (2021) Polyphenolic Inhibition of Enterocytic Starch Digestion Enzymes and Glucose Transporters for Managing Type 2 Diabetes May Be Reduced in Food Systems. Heliyon, 7, e06245.
https://doi.org/10.1016/j.heliyon.2021.e06245
[65]  Adewole, E., Yusuf, B., Ebitimitula, O., Ojo, A., Adewumi, D.F., Oludoro, O., et al. (2022) Phytochemicals Profile and In-Vitro Antidiabetic Potentials of Fractionated Extracts of Entada africana and Leptadenia hastata. ScienceRise: Pharmaceutical Science, 3, 65-73.
https://doi.org/10.15587/2519-4852.2022.255744
[66]  AL-Ishaq, R.K., Abotaleb, M., Kubatka, P., Kajo, K. and Büsselberg, D. (2019) Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels. Biomolecules, 9, Article 430.
https://doi.org/10.3390/biom9090430
[67]  Ríos, J., Andújar, I., Schinella, G.R. and Francini, F. (2019) Modulation of Diabetes by Natural Products and Medicinal Plants via Incretins. Planta Medica, 85, 825-839.
https://doi.org/10.1055/a-0897-7492
[68]  Li, Y., Cheng, K., Liu, I. and Niu, H. (2022) Myricetin Increases Circulating Adropin Level after Activation of Glucagon-Like Peptide 1 (GLP-1) Receptor in Type-1 Diabetic Rats. Pharmaceuticals, 15, Article 173.
https://doi.org/10.3390/ph15020173
[69]  Niisato, N. and Marunaka, Y. (2023) Therapeutic Potential of Multifunctional Myricetin for Treatment of Type 2 Diabetes Mellitus. Frontiers in Nutrition, 10, Article 1175660.
https://doi.org/10.3389/fnut.2023.1175660
[70]  Li, Y., Zheng, X., Yi, X., Liu, C., Kong, D., Zhang, J., et al. (2017) Myricetin: A Potent Approach for the Treatment of Type 2 Diabetes as a Natural Class B GPCR Agonist. The FASEB Journal, 31, 2603-2611.
https://doi.org/10.1096/fj.201601339r
[71]  Khan, W., Parveen, R., Chester, K., Parveen, S. and Ahmad, S. (2017) Hypoglycemic Potential of Aqueous Extract of Moringa oleifera Leaf and in Vivo GC-MS Metabolomics. Frontiers in Pharmacology, 8, Article 577.
https://doi.org/10.3389/fphar.2017.00577
[72]  Saltiel, A.R. and Kahn, C.R. (2001) Insulin Signalling and the Regulation of Glucose and Lipid Metabolism. Nature, 414, 799-806.
https://doi.org/10.1038/414799a
[73]  Miller, M., Stone, N.J., Ballantyne, C., Bittner, V., Criqui, M.H., Ginsberg, H.N., et al. (2011) Triglycerides and Cardiovascular Disease: A Scientific Statement from the American Heart Association. Circulation, 123, 2292-2333.
https://doi.org/10.1161/cir.0b013e3182160726
[74]  Adoga, J.O., Channa, M.L. and Nadar, A. (2021) Kolaviron Attenuates Cardiovascular Injury in Fructose-Streptozotocin Induced Type-2 Diabetic Male Rats by Reducing Oxidative Stress, Inflammation, and Improving Cardiovascular Risk Markers. Biomedicine & Pharmacotherapy, 144, Article ID: 112323.
https://doi.org/10.1016/j.biopha.2021.112323
[75]  Xiao, X., Luo, Y. and Peng, D. (2022) Updated Understanding of the Crosstalk between Glucose/Insulin and Cholesterol Metabolism. Frontiers in Cardiovascular Medicine, 9, Article 879355.
https://doi.org/10.3389/fcvm.2022.879355
[76]  Zheng, T., Shu, G., Yang, Z., Mo, S., Zhao, Y. and Mei, Z. (2012) Antidiabetic Effect of Total Saponins from Entada phaseoloides (L.) Merr. in Type 2 Diabetic Rats. Journal of Ethnopharmacology, 139, 814-821.
https://doi.org/10.1016/j.jep.2011.12.025
[77]  Ano, A.A.R.R., Koffi, E.N., Adima, A.A., N’da, P.K. and Anin, L.A. (2019) Composition biochimique et phytochimique des tourteaux des fruits du safoutier (Dacryodes edulis) de Côte d’Ivoire. International Journal of Biological and Chemical Sciences, 12, 2535-2546.
https://doi.org/10.4314/ijbcs.v12i6.6
[78]  Shukla, A., Brandsch, C., Bettzieche, A., Hirche, F., Stangl, G.I. and Eder, K. (2007) Isoflavone-Poor Soy Protein Alters the Lipid Metabolism of Rats by SREBP-Mediated Down-Regulation of Hepatic Genes. The Journal of Nutritional Biochemistry, 18, 313-321.
https://doi.org/10.1016/j.jnutbio.2006.05.007
[79]  Sun, W., Li, X., Dou, H., Wang, X., Li, J., Shen, L., et al. (2021) Myricetin Supplementation Decreases Hepatic Lipid Synthesis and Inflammation by Modulating Gut Microbiota. Cell Reports, 36, Article ID: 109641.
https://doi.org/10.1016/j.celrep.2021.109641
[80]  Chang, C.J., Tzeng, T., Liou, S., Chang, Y. and Liu, I. (2012) Myricetin Increases Hepatic Peroxisome Proliferator-Activated Receptorαprotein Expression and Decreases Plasma Lipids and Adiposity in Rats. Evidence-Based Complementary and Alternative Medicine, 2012, Article ID: 787152.
https://doi.org/10.1155/2012/787152
[81]  Babotă, M., Frumuzachi, O., Tanase, C. and Mocan, A. (2024) Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of in Vivo Mice Studies. Nutrients, 16, Article 3730.
https://doi.org/10.3390/nu16213730
[82]  Almatroodi, S.A. and Rahmani, A.H. (2025) Unlocking the Pharmacological Potential of Myricetin against Various Pathogenesis. International Journal of Molecular Sciences, 26, Article 4188.
https://doi.org/10.3390/ijms26094188
[83]  Oyedemi, S.O., Yakubu, M.T. and Afolayan, A.J. (2011) Antidiabetic Activities of Aqueous Leaves Extract of Leonotis leonurus in Streptozotocin-Induced Diabetic Rats. Journal of Medicinal Plants Research, 5, 119-125.
[84]  Sheneni, V.D., Shaibu, I.E., Okpe, J.M. and Omada, A.A. (2018) In-Vivo Biological Effect of Carica Papaya Leaf Extracts on P-407 Induced Hyperlipidemic Wistar Rats. MOJ Food Processing & Technology, 6, 409-412.
https://doi.org/10.15406/mojfpt.2018.06.00196
[85]  Hwang, Y.P., Choi, J.H., Kim, H.G., Lee, H., Chung, Y.C. and Jeong, H.G. (2013) Saponins from Platycodon grandiflorum Inhibit Hepatic Lipogenesis through Induction of SIRT1 and Activation of AMP-Activated Protein Kinase in High-Glucose-Induced HepG2 Cells. Food Chemistry, 140, 115-123.
https://doi.org/10.1016/j.foodchem.2013.02.041
[86]  Patel, R., Shah, P., Deshpande, S., Shah, G. and Gohil, P. (2015) Fructose Diet and Low Dose Streptozotocin Treatment Induces the Development of Diabetic Nephropathy in Rats. Oriental Pharmacy and Experimental Medicine, 15, 305-312.
https://doi.org/10.1007/s13596-015-0193-7
[87]  Rasool, S., Geetha, T., Broderick, T.L. and Babu, J.R. (2018) High Fat with High Sucrose Diet Leads to Obesity and Induces Myodegeneration. Frontiers in Physiology, 9, Article 1054.
https://doi.org/10.3389/fphys.2018.01054
[88]  Mohd Dom, N.S., Yahaya, N., Adam, Z., Nik Abd. Rahman, N.M.A. and Hamid, M. (2020) Antiglycation and Antioxidant Properties of Ficus deltoidea Varieties. Evidence-Based Complementary and Alternative Medicine, 2020, Article ID: 6374632.
https://doi.org/10.1155/2020/6374632
[89]  Silveira Rossi, J.L., Barbalho, S.M., Reverete de Araujo, R., Bechara, M.D., Sloan, K.P. and Sloan, L.A. (2021) Metabolic Syndrome and Cardiovascular Diseases: Going Beyond Traditional Risk Factors. Diabetes/Metabolism Research and Reviews, 38, e3502.
https://doi.org/10.1002/dmrr.3502
[90]  Assiri, A.M., Joumah, B.A., Alharthi, Y.S., Alanazi, O.S., Aljuned, A.A., Abed, A.A., et al. (2022) The Assessment of Liver Disease Utilizing a Panel of Liver Function Tests. International Journal of Pharmaceutical and Bio-Medical Science, 2, 327-332.
https://doi.org/10.47191/ijpbms/v2-i8-10
[91]  Best Practice Advocacy Center (BPAC) (2022) Liver Function Tests in Primary Care.
https://www.bpac.org.nz/2022/lfts.aspx
[92]  Sawieres, S. (2022) Liver Function Tests: Indication and Interpretation. The Pharmaceutical Journal, 308, 8 p.
[93]  Adeva-Andany, M.M., González-Lucán, M., Donapetry-García, C., Fernández-Fernández, C. and Ameneiros-Rodríguez, E. (2016) Glycogen Metabolism in Humans. BBA Clinical, 5, 85-100.
https://doi.org/10.1016/j.bbacli.2016.02.001
[94]  Jha, R., Lopez-Trevino, S., Kankanamalage, H.R. and Jha, J.C. (2024) Diabetes and Renal Complications: An Overview on Pathophysiology, Biomarkers and Therapeutic Interventions. Biomedicines, 12, Article 1098.
https://doi.org/10.3390/biomedicines12051098
[95]  Higgins, C. (2016) Urea and Creatinine Concentration, the Urea: Creatinine Ratio. 1-8.
https://acutecaretesting.org/en/articles/urea-and-creatinine-concentration-the-urea-creatinine-ratio
[96]  Harita, N., Hayashi, T., Sato, K.K., Nakamura, Y., Yoneda, T., Endo, G., et al. (2009) Lower Serum Creatinine Is a New Risk Factor of Type 2 Diabetes. Diabetes Care, 32, 424-426.
https://doi.org/10.2337/dc08-1265
[97]  Barkas, F., Elisaf, M., Liberopoulos, E., Kalaitzidis, R. and Liamis, G. (2017) Uric Acid and Incident Chronic Kidney Disease in Dyslipidemic Individuals. Current Medical Research and Opinion, 34, 1193-1199.
https://doi.org/10.1080/03007995.2017.1372157
[98]  Mei, Y., Dong, B., Geng, Z. and Xu, L. (2022) Excess Uric Acid Induces Gouty Nephropathy through Crystal Formation: A Review of Recent Insights. Frontiers in Endocrinology, 13, Article 911968.
https://doi.org/10.3389/fendo.2022.911968
[99]  Musimwa, A.M., Kanteng, G.W., Mutoke, G.N., Okito, K.N., Pongombo, M.Y. and Luboya, O.N. (2015) Variation de l’albuminémie au cours de la malnutrition protéino-energétique dans une zone urbano-rurale congolaise. Pan African Medical Journal, 20, Article 299.
https://doi.org/10.11604/pamj.2015.20.299.5794
[100]  Abu-zaiton, A.S. (2013) Evaluating the Effect of Silybum Marianum Extract on Blood Glucose, Liver and Kidney Functions in Diabetic Rats. Advanced Studies in Biology, 5, 447-454.
https://doi.org/10.12988/asb.2013.3936
[101]  Rehman, K. and Akash, M.S.H. (2017) Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? Journal of Cellular Biochemistry, 118, 3577-3585.
https://doi.org/10.1002/jcb.26097
[102]  Sivajothi, V., Dey, A., Jayakara, B. and Rajkapoor, B. (2008) Antihyperglycemic, Antihyperlipidemic and Antioxidant Effect of Phyllanthus rheedii on Streptozotocin-Induced Diabetic Rats. Iranian Journal of pharmaceutical Research, 7, e128570.
https://doi.org/10.22037/ijpr.2010.744
[103]  Cordiano, R., Di Gioacchino, M., Mangifesta, R., Panzera, C., Gangemi, S. and Minciullo, P.L. (2023) Malondialdehyde as a Potential Oxidative Stress Marker for Allergy-Oriented Diseases: An Update. Molecules, 28, Article 5979.
https://doi.org/10.3390/molecules28165979
[104]  Bennia Khadidja, B.G. (2020) Propriétés de la Plante Calendula arvensis. Master’s Thesis, Université Mohamed El Bachir El Ibrahim, 57 p.
[105]  Kougnimon, F., Dougnon, V., Anago, E., Bankole, H., Soumanou, M. and Loko, F. (2015) Propriétés Biologiques et Pharmacologiques de Terminalia superba Engl et Diels (Combretaceae): Synthèse Bibliographique. Algerian Journal of Natural Products, 3, 164-176.
[106]  Ozturk Sarikaya, S.B. (2015) Acethylcholinesterase Inhibitory Potential and Antioxidant Properties of Pyrogallol. Journal of Enzyme Inhibition and Medicinal Chemistry, 30, 761-766.
https://doi.org/10.3109/14756366.2014.965700
[107]  Upadhyay, G., Gupta, S.P., Prakash, O. and Singh, M.P. (2010) Pyrogallol-Mediated Toxicity and Natural Antioxidants: Triumphs and Pitfalls of Preclinical Findings and Their Translational Limitations. Chemico-Biological Interactions, 183, 333-340.
https://doi.org/10.1016/j.cbi.2009.11.028
[108]  Vuolo, M.M., Lima, V.S. and Maróstica Junior, M.R. (2019) Phenolic Compounds. In: Campos, M.R.S., Ed., Bioactive Compounds, Elsevier, 33-50.
https://doi.org/10.1016/b978-0-12-814774-0.00002-5
[109]  Faisal Hayat, M., Ur Rahman, A., Tahir, A., Batool, M., Ahmed, Z. and Atique, U. (2024) Palliative Potential of Robinetin to Avert Polystyrene Microplastics Instigated Pulmonary Toxicity in Rats. Journal of King Saud University—Science, 36, Article ID: 103348.
https://doi.org/10.1016/j.jksus.2024.103348
[110]  Imran, M., Saeed, F., Hussain, G., Imran, A., Mehmood, Z., Gondal, T.A., et al. (2021) Myricetin: A Comprehensive Review on Its Biological Potentials. Food Science & Nutrition, 9, 5854-5868.
https://doi.org/10.1002/fsn3.2513

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