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Medical Diagnosis 2026
小檗碱在牙周炎治疗中的研究进展
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Abstract:
牙周炎是一种常见的口腔慢性炎症，导致牙周组织破坏和牙齿丢失，其中牙周微生物群和宿主免疫反应共同参与组织破坏。小檗碱(Berberine)是一种主要提取自中国传统中药黄连的天然生物碱。目前，多项研究表明，小檗碱可以通过多种途径调节免疫，发挥良好的抗炎作用。在骨代谢方面，小檗碱通过影响多条信号通路抑制骨吸收并促进骨形成；在抗菌作用方面，小檗碱具有广谱抗菌性，并且能有效抑制牙周致病菌的生长。本文将从抗炎、促成骨、抗菌等三个方面对小檗碱的作用机制作一综述，并对其在牙周炎治疗中的进展进行总结，旨在为牙周炎的治疗提供新的思路。
Periodontitis is a common chronic oral inflammatory disease that leads to the destruction of periodontal tissues and tooth loss, in which the periodontal microbiota and host immune response jointly participate in tissue damage. Berberine is a natural alkaloid mainly extracted from Coptis chinensis, a traditional Chinese medicinal herb. At present, numerous studies have shown that berberine can regulate immunity through multiple pathways and exert a favorable anti-inflammatory effect. In terms of bone metabolism, berberine inhibits bone resorption and promotes bone formation by modulating multiple signaling pathways. In terms of antibacterial activity, berberine has a broad-spectrum antibacterial property and can effectively inhibit the growth of periodontal pathogenic bacteria. This paper reviews the mechanism of action of berberine from three aspects: anti-inflammation, osteogenesis promotion and antibacterial activity, and summarizes its research progress in the treatment of periodontitis, aiming to provide new ideas for the clinical treatment of periodontitis.
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