Management of a Heterotopic Pregnancy at the University Clinics of Kinshasa: A Case of a Triple Pregnancy; Removal of the Ectopic Pregnancy and Progression of the Intrauterine Twin Pregnancy
Heterotopic pregnancy is the coexistence of an intrauterine pregnancy and an extrauterine pregnancy, regardless of its location. It is an extremely rare condition, with an estimated prevalence of between 1 in 10,000 and 1 in 30,000 worldwide. Literature data show an increasing frequency of heterotopic pregnancies, becoming more common with the rise in medically assisted reproduction. According to U.S. data from ART (Assisted Reproduction Techniques), there were 485 heterotopic pregnancies out of 553,000 pregnancies conceived between 2001 and 2011, with the risk estimated at 1 in 1100 pregnancies, compared to 1 in 30,000 pregnancies for a spontaneous pregnancy. Its incidence is significant at an advanced age due to the higher likelihood of past gynecological infections and the rise in assisted reproductive technology (ART). The diagnosis remains difficult due to its confusing symptomatology. Diagnosis is often made with pelvic ultrasound, usually in the first trimester of pregnancy. Laparoscopy not only confirms the diagnosis but also allows for appropriate management today. The management of heterotopic pregnancies aims to remove the extrauterine pregnancy while preserving the intrauterine pregnancy as much as possible and limiting the risk of recurrence. Heterotopic pregnancy has implications for the maternal and fetal prognosis.
References
[1]
Julien, A., Gremeau, A.S., Campagne-Loiseau, S., et al. (2024) Case Report of an Exceptional Spontaneous Abdominal Heterotopic Pregnancy with Superfetation: Diagnosis and Treatment: Heterotopic Pregnancy with Superfetation (8 + 1 WG & 5 + 4 WG). Journal of Gynecology Obstetrics and Human Reproduction, 53, Article 102701. https://doi.org/10.1016/j.jogoh.2023.102701
[2]
Channiss, L., Tahle, T., Sabouni, R. and Jamalih, M. (2023) Heterotopic Pregnancy with Superfetation Following Ovarian Stimulation: A Case Report. CaseReportsinWomen’sHealth, 40, e00562. https://doi.org/10.1016/j.crwh.2023.e00562
[3]
Moore, J.W. and Sale, E.P. (1870) Cases of Extra and Intra Uterine Foetation Occurring Conjointly: With Operation Therefor, Resulting in the Death of the Mother and the Saving of Two Living Children. New Orleans Journal, 23, Article 727. https://archive.org/details/paper-doi-10_1097_00000441-187101000-00131
[4]
Diallo, D., Aubard, Y., Piver, P. and Baudet, J.H. (2000) Grossesse hétérotopique: A propos de 5 cas et revue de la littérature. Journal de gynécologie, obstétrique et biologie de la reproduction, 29, 131-141.
[5]
Bambara, M., Dao, B., Toure, B., Ouedraogo, B., et al. (2002) Grossesses hétérotopiques: À propos de trois cas. Louvain Medical, 121, 383-387.
[6]
Sherer, D.M., Scibetta, J.J. and Sanko, S.R. (1995) Heterotopic Quadruplet Gestation with Laparoscopic Resection of Ruptured Interstitial Pregnancy and Subsequent Successful Outcome of Triplets. AmericanJournalofObstetricsandGynecology, 172, 216-217. https://doi.org/10.1016/0002-9378(95)90119-1
[7]
Su, W.H., Wang, P.H. and Chang, S.H. (1998) Unusual Presentation of Heterotopic Pregnancy: A Case Report. Chinese Medical Journal, 61, 608-612.
[8]
Christiane, T., Justin, D., Benjamin, H., et al. (2015) Heterotopic Pregnancy in the University Clinic of Gynecology and Obstetrics of the National Hospital and University of Benin Hubert Maga Koutoukou: Report of a Case of Quadruple Pregnancy. Pan African Medical Journal, 20, Article 394.
[9]
Dimitry, E.S., Subak-Sharpe, R., Mills, M., Margara, R. and Winston, R. (1990) Nine Cases of Heterotopic Pregnancies in 4 Years of in Vitro Fertilization. FertilityandSterility, 53, 107-110. https://doi.org/10.1016/s0015-0282(16)53225-7
[10]
Ousehal, A., Mamouchi, H., Ghazli, M. and Kadiri, R. (2001) Grossesse hétérotopique: Intérêt de l’échographie sus pubienne (à propos d’un cas). Journal of Radiology, 82, 851-853.
[11]
Wallach, E.E., Tal, J., Haddad, S., Gordon, N. and Timor-Tritsch, I. (1996) Heterotopic Pregnancy after Ovulation Induction and Assisted Reproductive Technologies: A Literature Review from 1971 to 1993. Fertility and Sterility, 66, 1-12. https://doi.org/10.1016/s0015-0282(16)58378-2
[12]
Jibodu, O.A. and Darne, F.J. (1997) Spontaneous Heterotopic Pregnancy Presenting with Tubal Rupture. Human Reproduction, 12, 1098-1099. https://doi.org/10.1093/humrep/12.5.1098
[13]
Laghzaoui Boukaïdi, M., Bouhya, S., Sefrioui, O., Bennani, O., Hermas, S. and Aderdour, M. (2002) Grossesses hétérotopiques: À propos de huit cas. Gynécologie Obstétrique & Fertilité, 30, 218-223. https://doi.org/10.1016/s1297-9589(02)00298-9
[14]
Simsek, T., Dogan, A., Simsek, M. and Pestereli, E. (2008) Heterotopic Triplet Pregnancy (Twin Tubal) in a Natural Cycle with Tubal Rupture: Case Report and Review of the Literature. Journal of Obstetrics and Gynaecology Research, 34, 759-762. https://doi.org/10.1111/j.1447-0756.2008.00921.x
[15]
De Francesh, F., Dileo, L. and Martinez, J. (1999) Heteotopic Pregnancy: Discovery of Ectopic Pregnancy after Elective Abortion. SouthernMedicalJournal, 92, 330-332. https://doi.org/10.1097/00007611-199903000-00016
[16]
Sefroui, O., Azyer, M., Babahabib, A., Kaanane, F. and Matar, N. (2004) Pregnancy in Rudimentary Uterine Horn: Diagnosis and Therapeutic Difficulties. Gynécologie Obstétrique & Fertilité, 32, 308-310. https://doi.org/10.1016/j.gyobfe.2004.01.015
[17]
Habana, A., Dokras, A., Giraldo, J.L. and Jones, E.E. (2000) Cornual Heterotopic Pregnancy: Contemporary Management Options. American Journal of Obstetrics andGynecology, 182, 1264-1270. https://doi.org/10.1067/mob.2000.103620
[18]
Bornstein, E., Berg, R., Santos, R., Monteagudo, A. and Timor-Tritsch, I.E. (2011) Term Singleton Pregnancy after Conservative Management of a Complicated Triplet Gestation Including a Heterotopic Cornual Monochorionic Twin Pair. JournalofUltrasoundinMedicine, 30, 865-867. https://doi.org/10.7863/jum.2011.30.6.865