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Biogenic Nanoparticles in Cardiovascular Disease: Current Insights and Future Prospects

DOI: 10.4236/anp.2026.151001, PP. 1-36

Keywords: Green Synthesis, Nanoparticles, Cardiovascular, Diseases

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Abstract:

Cardiovascular diseases, particularly myocardial infarction (MI), remain the leading cause of mortality worldwide. The search for novel therapeutic strategies has led to growing interest in green-synthesized nanoparticles as supportive agents in cardiovascular therapy. These biofunctionalized nanoparticles, derived from natural sources such as plants and microbes, offer several advantages, including eco-friendly synthesis, low-cost production, enhanced biocompatibility, improved bioavailability, and reduced toxicity. Nanoparticles target mitochondrial membranes in ischemic cardiomyocytes, where they deliver reactive oxygen species scavengers to alleviate oxidative stress. They have been shown to lower blood pressure, suppress nuclear factor kappa B (NF-κB) signaling, and reduce the expression of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-alpha (TNF-α). Moreover, we highlight advances in nanoparticle-mediated gene regulation, including the delivery of small interfering RNA (siRNA) to silence key atherogenic targets such as proprotein convertase subtilisin/kexin type 9 (PCSK9) and apolipoprotein B (ApoB). They have demonstrated anti-atherosclerotic activity by reducing foam cell formation in THP-1 monocyte-derived macrophages and inhibiting apoptosis, lipid peroxidation, and production of NADPH-derived superoxides, and stabilizing levels of serum creatine and cardiotropins in myocardial infarcted animals. This review synthesizes current scientific evidence on the clinical relevance and mechanistic pathways of green nanoparticles in cardiovascular medicine, aiming to guide future research and inspire the development of next-generation therapeutics.

 References

[1]  Baudin, B., Cohen, A., Berthelot-Garcias, E., Meuleman, C., Dufaitre, G., Ederhy, S., et al. (2009) Données épidémiologiques des maladies cardiovasculaires et prise en charge des accidents cardiovasculaires. Revue Francophone des Laboratoires, 2009, 27-39.
https://doi.org/10.1016/s1773-035x(09)70198-4
[2]  World Health Organization (2014) World Health Organization in Global Status Report on Noncommunicable Diseases 2014. World Health Organization.
https://www.who.int/publications/i/item/9789241564854
[3]  Gundogdu, E., Senyigit, Z. and Ilem-Ozdemir, D. (2014) Nanomedicine for the Diagnosis and Treatment of Cardiovascular Disease: Current Status and Future Perspective. Cardiovascular Disease, Concept Press Ltd., 187-201.
[4]  Fan, C., Zhang, E., Joshi, J., Yang, J., Zhang, J. and Zhu, W. (2020) Utilization of Human Induced Pluripotent Stem Cells for Cardiac Repair. Frontiers in Cell and Developmental Biology, 8, Article 36.
https://doi.org/10.3389/fcell.2020.00036
[5]  Smith, B.R. and Gambhir, S.S. (2017) Nanomaterials for in Vivo Imaging. Chemical Reviews, 117, 901-986.
https://doi.org/10.1021/acs.chemrev.6b00073
[6]  Felici, A., Di Mascolo, D., Ferreira, M., Lauciello, S., Bono, L., Armirotti, A., et al. (2021) Vascular-Confined Multi-Passage Discoidal Nanoconstructs for the Low-Dose Docetaxel Inhibition of Triple-Negative Breast Cancer Growth. Nano Research, 15, 482-491.
https://doi.org/10.1007/s12274-021-3507-8
[7]  Patra, J.K., Das, G., Fraceto, L.F., Campos, E.V.R., Rodriguez-Torres, M.D.P., Acosta-Torres, L.S., et al. (2018) Nano Based Drug Delivery Systems: Recent Developments and Future Prospects. Journal of Nanobiotechnology, 16, Article No. 71.
https://doi.org/10.1186/s12951-018-0392-8
[8]  Chavali, M.S. and Nikolova, M.P. (2019) Metal Oxide Nanoparticles and Their Applications in Nanotechnology. SN Applied Sciences, 1, Article No. 607.
https://doi.org/10.1007/s42452-019-0592-3
[9]  Nagar, A., Kumar, A., Parveen, S., Kumar, A., Dhasmana, H., Husain, S., et al. (2020) Zinc Oxide Nanoflowers Synthesized by Sol-Gel Technique for Field Emission Displays (FEDs). Materials Today: Proceedings, 32, 402-406.
https://doi.org/10.1016/j.matpr.2020.02.087
[10]  Tiede, K., Boxall, A.B.A., Tiede, D., Tear, S.P., David, H. and Lewis, J. (2009) A Robust Size-Characterisation Methodology for Studying Nanoparticle Behaviour in ‘Real’ Environmental Samples, Using Hydrodynamic Chromatography Coupled to ICP-MS. Journal of Analytical Atomic Spectrometry, 24, 964-972.
https://doi.org/10.1039/b822409a
[11]  Devi, H.S., Boda, M.A., Shah, M.A., Parveen, S. and Wani, A.H. (2018) Green Synthesis of Iron Oxide Nanoparticles Using Platanus orientalis Leaf Extract for Antifungal Activity. Green Processing and Synthesis, 8, 38-45.
https://doi.org/10.1515/gps-2017-0145
[12]  Sone, B.T., Diallo, A., Fuku, X.G., Gurib-Fakim, A. and Maaza, M. (2020) Biosynthesized CuO Nano-Platelets: Physical Properties & Enhanced Thermal Conductivity Nanofluidics. Arabian Journal of Chemistry, 13, 160-170.
https://doi.org/10.1016/j.arabjc.2017.03.004
[13]  Ehrampoush, M.H., Miria, M., Salmani, M.H. and Mahvi, A.H. (2015) Cadmium Removal from Aqueous Solution by Green Synthesis Iron Oxide Nanoparticles with Tangerine Peel Extract. Journal of Environmental Health Science and Engineering, 13, Article No. 84.
https://doi.org/10.1186/s40201-015-0237-4
[14]  Kumar, B., Smita, K., Cumbal, L., Debut, A. and Angulo, Y. (2017) Biofabrication of Copper Oxide Nanoparticles Using Andean Blackberry (Rubus glaucus Benth.) Fruit and Leaf. Journal of Saudi Chemical Society, 21, S475-S480.
https://doi.org/10.1016/j.jscs.2015.01.009
[15]  Dhand, V., Soumya, L., Bharadwaj, S., Chakra, S., Bhatt, D. and Sreedhar, B. (2016) Green Synthesis of Silver Nanoparticles Using Coffea Arabica Seed Extract and Its Antibacterial Activity. Materials Science and Engineering: C, 58, 36-43.
https://doi.org/10.1016/j.msec.2015.08.018
[16]  Pillai, A.M., Sivasankarapillai, V.S., Rahdar, A., Joseph, J., Sadeghfar, F., Anuf A, R., et al. (2020) Green Synthesis and Characterization of Zinc Oxide Nanoparticles with Antibacterial and Antifungal Activity. Journal of Molecular Structure, 1211, Article ID: 128107.
https://doi.org/10.1016/j.molstruc.2020.128107
[17]  Abdullah, F.H., Abu Bakar, N.H.H. and Abu Bakar, M. (2020) Low Temperature Biosynthesis of Crystalline Zinc Oxide Nanoparticles from Musa Acuminata Peel Extract for Visible-Light Degradation of Methylene Blue. Optik, 206, Article ID: 164279.
https://doi.org/10.1016/j.ijleo.2020.164279
[18]  Nadeem, M., Khan, R., Afridi, K., Nadhman, A., Ullah, S., Faisal, S., et al. (2020) Green Synthesis of Cerium Oxide Nanoparticles (CeO2 NPs) and Their Antimicrobial Applications: A Review. International Journal of Nanomedicine, 15, 5951-5961.
https://doi.org/10.2147/ijn.s255784
[19]  Nune, S.K., Chanda, N., Shukla, R., Katti, K., Kulkarni, R.R., Thilakavathy, S., et al. (2009) Green Nanotechnology from Tea: Phytochemicals in Tea as Building Blocks for Production of Biocompatible Gold Nanoparticles. Journal of Materials Chemistry, 19, 2912-2920.
https://doi.org/10.1039/b822015h
[20]  Kumari, P. and Meena, A. (2020) Green Synthesis of Gold Nanoparticles from Lawsoniainermis and Its Catalytic Activities Following the Langmuir-Hinshelwood Mechanism. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 606, Article ID: 125447.
https://doi.org/10.1016/j.colsurfa.2020.125447
[21]  Teixeira, L.M., Reis, C.P. and Pacheco, R. (2024) Potential of Application of Natural Product Nanoparticles in Hypercholesterolemia. Chemistry Proceedings, 16, Article 84.
https://doi.org/10.3390/ecsoc-28-20168
[22]  Xu, B., Watkins, R., Wu, L., Zhang, C. and Davis, R. (2015) Natural Product-Based Nanomedicine: Recent Advances and Issues. International Journal of Nanomedicine, 10, 6055-6074.
https://doi.org/10.2147/ijn.s92162
[23]  Bodeker, G., Bhat, K.K.S., Burley, J. and Vantomme, P. (1997) Medicinal Plants for Forest Conservation and Health Care. FAO, 100-108.
[24]  Chen, S., Li, Q., McClements, D.J., Han, Y., Dai, L., Mao, L., et al. (2020) Co-Delivery of Curcumin and Piperine in Zein-Carrageenan Core-Shell Nanoparticles: Formation, Structure, Stability and in Vitro Gastrointestinal Digestion. Food Hydrocolloids, 99, Article ID: 105334.
https://doi.org/10.1016/j.foodhyd.2019.105334
[25]  Fazal, H., Abbasi, B.H., Ahmad, N. and Ali, M. (2016) Elicitation of Medicinally Important Antioxidant Secondary Metabolites with Silver and Gold Nanoparticles in Callus Cultures of Prunella vulgaris L. Applied Biochemistry and Biotechnology, 180, 1076-1092.
https://doi.org/10.1007/s12010-016-2153-1
[26]  Parveen, K., Banse, V. and Ledwani, L. (2016) Green Synthesis of Nanoparticles: Their Advantages and Disadvantages. AIP Conference Proceedings, 1724, Article ID: 020048.
https://doi.org/10.1063/1.4945168
[27]  Rad, S.S., Sani, A.M. and Mohseni, S. (2019) Biosynthesis, Characterization and Antimicrobial Activities of Zinc Oxide Nanoparticles from Leaf Extract of Mentha pulegium (L.). Microbial Pathogenesis, 131, 239-245.
https://doi.org/10.1016/j.micpath.2019.04.022
[28]  Kasthuri, K., Kishor Kumar, J., Rajkumar, P., Amala Jeya Ranchani, A. and Jayaprakash, K. (2024) Bio-Inspired Synthesis of ZnO Nanoparticles Using Taraxacum Officinale for Antibacterial, Antifungal, and Anticancer Applications. Inorganic Chemistry Communications, 170, Article ID: 113409.
https://doi.org/10.1016/j.inoche.2024.113409
[29]  Bouafia, A. and Laouini, S.E. (2020) Green Synthesis of Iron Oxide Nanoparticles by Aqueous Leaves Extract of Mentha pulegium L.: Effect of Ferric Chloride Concentration on the Type of Product. Materials Letters, 265, Article ID: 127364.
https://doi.org/10.1016/j.matlet.2020.127364
[30]  Jha, A.K. and Prasad, K. (2010) Green Synthesis of Silver Nanoparticles Using Cycas Leaf. International Journal of Green Nanotechnology: Physics and Chemistry, 1, P110-P117.
https://doi.org/10.1080/19430871003684572
[31]  Medina-Ramirez, I., Bashir, S., Luo, Z. and Liu, J.L. (2009) Green Synthesis and Characterization of Polymer-Stabilized Silver Nanoparticles. Colloids and Surfaces B: Biointerfaces, 73, 185-191.
https://doi.org/10.1016/j.colsurfb.2009.05.015
[32]  Jafarirad, S., Mehrabi, M., Divband, B. and Kosari-Nasab, M. (2016) Biofabrication of Zinc Oxide Nanoparticles Using Fruit Extract of Rosa canina and Their Toxic Potential against Bacteria: A Mechanistic Approach. Materials Science and Engineering: C, 59, 296-302.
https://doi.org/10.1016/j.msec.2015.09.089
[33]  Yuvakkumar, R., Suresh, J., Nathanael, A.J., Sundrarajan, M. and Hong, S.I. (2014) Novel Green Synthetic Strategy to Prepare ZnO Nanocrystals Using Rambutan (Nephelium lappaceum L.) Peel Extract and Its Antibacterial Applications. Materials Science and Engineering: C, 41, 17-27.
https://doi.org/10.1016/j.msec.2014.04.025
[34]  Çolak, H. and Karaköse, E. (2017) Green Synthesis and Characterization of Nanostructured ZnO Thin Films Using Citrus Aurantifolia (Lemon) Peel Extract by Spin-Coating Method. Journal of Alloys and Compounds, 690, 658-662.
https://doi.org/10.1016/j.jallcom.2016.08.090
[35]  Melkamu, W.W. and Bitew, L.T. (2021) Green Synthesis of Silver Nanoparticles Using Hagenia abyssinica (Bruce) J.F. Gmel Plant Leaf Extract and Their Antibacterial and Anti-Oxidant Activities. Heliyon, 7, e08459.
https://doi.org/10.1016/j.heliyon.2021.e08459
[36]  Shafey, A.M.E. (2020) Green Synthesis of Metal and Metal Oxide Nanoparticles from Plant Leaf Extracts and Their Applications: A Review. Green Processing and Synthesis, 9, 304-339.
https://doi.org/10.1515/gps-2020-0031
[37]  Jayarambabu, N., Akshaykranth, A., Venkatappa Rao, T., Venkateswara Rao, K. and Rakesh Kumar, R. (2020) Green Synthesis of Cu Nanoparticles Using Curcuma Longa Extract and Their Application in Antimicrobial Activity. Materials Letters, 259, Article ID: 126813.
https://doi.org/10.1016/j.matlet.2019.126813
[38]  Schreiber, M., Vivekanandhan, S., Kumar Mohanty, A. and Misra, M. (2012) A Study on the Electrospinning Behaviour and Nanofibre Morphology of Anionically Charged Lignin. Advanced Materials Letters, 3, 476-480.
https://doi.org/10.5185/amlett.2012.icnano.336
[39]  Soto-Robles, C.A., Luque, P.A., Gómez-Gutiérrez, C.M., Nava, O., Vilchis-Nestor, A.R., Lugo-Medina, E., et al. (2019) Study on the Effect of the Concentration of Hibiscus sabdariffa Extract on the Green Synthesis of ZnO Nanoparticles. Results in Physics, 15, Article ID: 102807.
https://doi.org/10.1016/j.rinp.2019.102807
[40]  Dousari, A.S., Hosseininasab, S.S., Akbarizadeh, M.R., Naderifar, M. and Satarzadeh, N. (2023) Mentha pulegium as a Source of Green Synthesis of Nanoparticles with Antibacterial, Antifungal, Anticancer, and Antioxidant Applications. Scientia Horticulturae, 320, Article ID: 112215.
https://doi.org/10.1016/j.scienta.2023.112215
[41]  Jafarizad, A., Safaee, K., Gharibian, S., Omidi, Y. and Ekinci, D. (2015) Biosynthesis and In-Vitro Study of Gold Nanoparticles Using Mentha and Pelargonium Extracts. Procedia Materials Science, 11, 224-230.
https://doi.org/10.1016/j.mspro.2015.11.113
[42]  Saka, A., Jule, L.T., Soressa, S., Gudata, L., Nagaprasad, N., Seenivasan, V., et al. (2022) Biological Approach Synthesis and Characterization of Iron Sulfide (FeS) Thin Films from Banana Peel Extract for Contamination of Environmental Remediation. Scientific Reports, 12, Article No. 10486.
https://doi.org/10.1038/s41598-022-14828-0
[43]  Negi, A., Gangwar, R., Kumar Vishwakarma, R. and Singh Negi, D. (2022) Antibacterial, Antioxidant and Photodegradation Potential of ZnO Nanoparticles Mediated via Roots of Taraxacum Officinale Radix. Materials Today: Proceedings, 57, 2435-2443.
https://doi.org/10.1016/j.matpr.2022.02.019
[44]  Hai, N.D., Dat, N.M., Huong, L.M., Tai, L.T., Thinh, D.B., Nam, N.T.H., et al. (2022) Phytosynthesis of Silver Nanoparticles Using Mangifera Indica Leaves Extract at Room Temperature: Formation Mechanism, Catalytic Reduction, Colorimetric Sensing, and Antimicrobial Activity. Colloids and Surfaces B: Biointerfaces, 220, Article ID: 112974.
https://doi.org/10.1016/j.colsurfb.2022.112974
[45]  Li, Z., Wang, L., Chen, S., Feng, C., Chen, S., Yin, N., et al. (2014) Facilely Green Synthesis of Silver Nanoparticles into Bacterial Cellulose. Cellulose, 22, 373-383.
https://doi.org/10.1007/s10570-014-0487-9
[46]  Ganesh Kumar, C., Poornachandra, Y. and Mamidyala, S.K. (2014) Green Synthesis of Bacterial Gold Nanoparticles Conjugated to Resveratrol as Delivery Vehicles. Colloids and Surfaces B: Biointerfaces, 123, 311-317.
https://doi.org/10.1016/j.colsurfb.2014.09.032
[47]  Syame, S.M., Mansour, A.S., Khalaf, D.D., Ibrahim, E.S. and Gaber, E.S. (2020) Green Synthesis of Silver Nanoparticles Using Lactic Acid Bacteria: Assessment of Antimicrobial Activity. World’s Veterinary Journal, 10, 625-633.
https://doi.org/10.54203/scil.2020.wvj75
[48]  Khan, F., Shahid, A., Zhu, H., Wang, N., Javed, M.R., Ahmad, N., et al. (2022) Prospects of Algae-Based Green Synthesis of Nanoparticles for Environmental Applications. Chemosphere, 293, Article ID: 133571.
https://doi.org/10.1016/j.chemosphere.2022.133571
[49]  Alprol, A.E., Mansour, A.T., El-Beltagi, H.S. and Ashour, M. (2023) Algal Extracts for Green Synthesis of Zinc Oxide Nanoparticles: Promising Approach for Algae Bioremediation. Materials, 16, Article 2819.
https://doi.org/10.3390/ma16072819
[50]  Arun, G., Eyini, M. and Gunasekaran, P. (2014) Green Synthesis of Silver Nanoparticles Using the Mushroom Fungus Schizophyllum commune and Its Biomedical Applications. Biotechnology and Bioprocess Engineering, 19, 1083-1090.
https://doi.org/10.1007/s12257-014-0071-z
[51]  Molnár, Z., Bódai, V., Szakacs, G., Erdélyi, B., Fogarassy, Z., Sáfrán, G., et al. (2018) Green Synthesis of Gold Nanoparticles by Thermophilic Filamentous Fungi. Scientific Reports, 8, Article No. 3943.
https://doi.org/10.1038/s41598-018-22112-3
[52]  Clarance, P., Luvankar, B., Sales, J., Khusro, A., Agastian, P., Tack, J., et al. (2020) Green Synthesis and Characterization of Gold Nanoparticles Using Endophytic Fungi Fusarium solani and Its In-Vitro Anticancer and Biomedical Applications. Saudi Journal of Biological Sciences, 27, 706-712.
https://doi.org/10.1016/j.sjbs.2019.12.026
[53]  Gade, A., Gaikwad, S., Duran, N. and Rai, M. (2014) Green Synthesis of Silver Nanoparticles by Phoma glomerata. Micron, 59, 52-59.
https://doi.org/10.1016/j.micron.2013.12.005
[54]  Li, G., He, D., Qian, Y., Guan, B., Gao, S., Cui, Y., et al. (2011) Fungus-mediated Green Synthesis of Silver Nanoparticles Using Aspergillus terreus. International Journal of Molecular Sciences, 13, 466-476.
https://doi.org/10.3390/ijms13010466
[55]  Alhazzazi, T.Y., Alzebiani, N.A., Alotaibi, S.K., Bogari, D.F., Bakalka, G.T., Hazzazi, L.W., et al. (2016) Awareness and Attitude toward Using Dental Magnification among Dental Students and Residents at King Abdulaziz University, Faculty of Dentistry. BMC Oral Health, 17, Article No. 21.
https://doi.org/10.1186/s12903-016-0254-4
[56]  Wang, D., Xue, B., Wang, L., Zhang, Y., Liu, L. and Zhou, Y. (2021) Fungus-Mediated Green Synthesis of Nano-Silver Using Aspergillus sydowii and Its Antifungal/Antiproliferative Activities. Scientific Reports, 11, Article No. 10356.
https://doi.org/10.1038/s41598-021-89854-5
[57]  Guyton, J.R. and Klemp, K.F. (1996) Development of the Lipid-Rich Core in Human Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 16, 4-11.
https://doi.org/10.1161/01.atv.16.1.4
[58]  Zhang, J., Nie, S. and Wang, S. (2013) Nanoencapsulation Enhances Epigallocatechin-3-Gallate Stability and Its Antiatherogenic Bioactivities in Macrophages. Journal of Agricultural and Food Chemistry, 61, 9200-9209.
https://doi.org/10.1021/jf4023004
[59]  Pillai, S.C., Borah, A., Le, M.N.T., Kawano, H., Hasegawa, K. and Kumar, D.S. (2021) Co-delivery of Curcumin and Bioperine via PLGA Nanoparticles to Prevent Atherosclerotic Foam Cell Formation. Pharmaceutics, 13, Article 1420.
https://doi.org/10.3390/pharmaceutics13091420
[60]  Meng, N., Gong, Y., Zhang, J., Mu, X., Song, Z., Feng, R., et al. (2018) A Novel Curcumin-Loaded Nanoparticle Restricts Atherosclerosis Development and Promotes Plaques Stability in Apolipoprotein E Deficient Mice. Journal of Biomaterials Applications, 33, 946-954.
https://doi.org/10.1177/0885328218815328
[61]  Randhawa, G., Kullar, J. and Rajkumar, (2011) Bioenhancers from Mother Nature and Their Applicability in Modern Medicine. International Journal of Applied and Basic Medical Research, 1, 5-10.
https://doi.org/10.4103/2229-516x.81972
[62]  Carlson, L.J., Cote, B., Alani, A.W.G. and Rao, D.A. (2014) Polymeric Micellar Co-Delivery of Resveratrol and Curcumin to Mitigate in Vitro Doxorubicin-Induced Cardiotoxicity. Journal of Pharmaceutical Sciences, 103, 2315-2322.
https://doi.org/10.1002/jps.24042
[63]  Li, J., Zhou, Y., Zhang, W., Bao, C. and Xie, Z. (2017) Relief of Oxidative Stress and Cardiomyocyte Apoptosis by Using Curcumin Nanoparticles. Colloids and Surfaces B: Biointerfaces, 153, 174-182.
https://doi.org/10.1016/j.colsurfb.2017.02.023
[64]  Zhang, J., Wang, Y., Bao, C., Liu, T., Li, S., Huang, J., et al. (2019) Curcumin-Loaded PEG-PDLLA Nanoparticles for Attenuating Palmitate-Induced Oxidative Stress and Cardiomyocyte Apoptosis through AMPK Pathway. International Journal of Molecular Medicine, 44, 672-682.
https://doi.org/10.3892/ijmm.2019.4228
[65]  Nabofa, W.E.E., Alashe, O.O., Oyeyemi, O.T., Attah, A.F., Oyagbemi, A.A., Omobowale, T.O., et al. (2018) Cardioprotective Effects of Curcumin-Nisin Based Poly Lactic Acid Nanoparticle on Myocardial Infarction in Guinea Pigs. Scientific Reports, 8, Article No. 16649.
https://doi.org/10.1038/s41598-018-35145-5
[66]  Ray, A., Rana, S., Banerjee, D., Mitra, A., Datta, R., Naskar, S., et al. (2016) Improved Bioavailability of Targeted Curcumin Delivery Efficiently Regressed Cardiac Hypertrophy by Modulating Apoptotic Load within Cardiac Microenvironment. Toxicology and Applied Pharmacology, 290, 54-65.
https://doi.org/10.1016/j.taap.2015.11.011
[67]  R. Neves, A., Lucio, M., L.C. Lima, J. and Reis, S. (2012) Resveratrol in Medicinal Chemistry: A Critical Review of Its Pharmacokinetics, Drug-Delivery, and Membrane Interactions. Current Medicinal Chemistry, 19, 1663-1681.
https://doi.org/10.2174/092986712799945085
[68]  de la Lastra, C.A. and Villegas, I. (2007) Resveratrol as an Antioxidant and Pro-Oxidant Agent: Mechanisms and Clinical Implications. Biochemical Society Transactions, 35, 1156-1160.
https://doi.org/10.1042/bst0351156
[69]  Liao, P., Ng, L., Lin, L., Richardson, C.D., Wang, G. and Lin, C. (2010) Resveratrol Arrests Cell Cycle and Induces Apoptosis in Human Hepatocellular Carcinoma Huh-7 Cells. Journal of Medicinal Food, 13, 1415-1423.
https://doi.org/10.1089/jmf.2010.1126
[70]  Frémont, L. (2000) Biological Effects of Resveratrol. Life Sciences, 66, 663-673.
https://doi.org/10.1016/s0024-3205(99)00410-5
[71]  Cheng, Y., Liu, D., Zhang, C., Cui, H., Liu, M., Zhang, B., et al. (2019) Mitochondria-targeted Antioxidant Delivery for Precise Treatment of Myocardial Ischemia-Reperfusion Injury through a Multistage Continuous Targeted Strategy. Nanomedicine: Nanotechnology, Biology and Medicine, 16, 236-249.
https://doi.org/10.1016/j.nano.2018.12.014
[72]  Hardy, N., Viola, H.M., Johnstone, V.P.A., Clemons, T.D., Cserne Szappanos, H., Singh, R., et al. (2014) Nanoparticle-Mediated Dual Delivery of an Antioxidant and a Peptide against the L-Type Ca2+ Channel Enables Simultaneous Reduction of Cardiac Ischemia-Reperfusion Injury. ACS Nano, 9, 279-289.
https://doi.org/10.1021/nn5061404
[73]  Patel, R.V., Mistry, B.M., Shinde, S.K., Syed, R., Singh, V. and Shin, H. (2018) Therapeutic Potential of Quercetin as a Cardiovascular Agent. European Journal of Medicinal Chemistry, 155, 889-904.
https://doi.org/10.1016/j.ejmech.2018.06.053
[74]  Porcu, E.P., Cossu, M., Rassu, G., Giunchedi, P., Cerri, G., Pourová, J., et al. (2018) Aqueous Injection of Quercetin: An Approach for Confirmation of Its Direct in Vivo Cardiovascular Effects. International Journal of Pharmaceutics, 541, 224-233.
https://doi.org/10.1016/j.ijpharm.2018.02.036
[75]  Kleemann, R., Verschuren, L., Morrison, M., Zadelaar, S., van Erk, M.J., Wielinga, P.Y., et al. (2011) Anti-Inflammatory, Anti-Proliferative and Anti-Atherosclerotic Effects of Quercetin in Human in Vitro and in Vivo Models. Atherosclerosis, 218, 44-52.
https://doi.org/10.1016/j.atherosclerosis.2011.04.023
[76]  Zahedi, M., Ghiasvand, R., Feizi, A., Asgari, G. and Darvish, L. (2013) Does Quercetin Improve Cardiovascular Risk Factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-Blind Randomized Controlled Clinical Trial. International Journal of Preventive Medicine, 4, 777-785.
[77]  Salehi, B., Machin, L., Monzote, L., Sharifi-Rad, J., Ezzat, S.M., Salem, M.A., et al. (2020) Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health. ACS Omega, 5, 11849-11872.
https://doi.org/10.1021/acsomega.0c01818
[78]  Giannouli, M., Karagkiozaki, V., Pappa, F., Moutsios, I., Gravalidis, C. and Logothetidis, S. (2018) Fabrication of Quercetin-Loaded PLGA Nanoparticles via Electrohydrodynamic Atomization for Cardiovascular Disease. Materials Today: Proceedings, 5, 15998-16005.
https://doi.org/10.1016/j.matpr.2018.05.044
[79]  Li, H., Sureda, A., Devkota, H.P., Pittalà, V., Barreca, D., Silva, A.S., et al. (2020) Curcumin, the Golden Spice in Treating Cardiovascular Diseases. Biotechnology Advances, 38, Article ID: 107343.
https://doi.org/10.1016/j.biotechadv.2019.01.010
[80]  Duan, Y., Gong, K., Xu, S., Zhang, F., Meng, X. and Han, J. (2022) Regulation of Cholesterol Homeostasis in Health and Diseases: From Mechanisms to Targeted Therapeutics. Signal Transduction and Targeted Therapy, 7, Article No. 265.
https://doi.org/10.1038/s41392-022-01125-5
[81]  Mulder, W.J.M., Strijkers, G.J., van Tilborg, G.A.F., Griffioen, A.W. and Nicolay, K. (2006) MR in Biomedicine: An International Journal Devoted to the Development and Application of Magnetic Resonance In Vivo 2006, 19, 142-164.
[82]  Shade, C.W. (2016) Liposomes as Advanced Delivery Systems for Nutraceuticals. Integrative Medicine (Encinitas, Calif.), 15, 33-36.
[83]  Wang, S., Chen, Y., Guo, J. and Huang, Q. (2023) Liposomes for Tumor Targeted Therapy: A Review. International Journal of Molecular Sciences, 24, Article 2643.
https://doi.org/10.3390/ijms24032643
[84]  Mitragotri, S. and Stayton, P. (2014) Organic Nanoparticles for Drug Delivery and Imaging. MRS Bulletin, 39, 219-223.
https://doi.org/10.1557/mrs.2014.11
[85]  Barenholz, Y. (2012) Doxil®—The First FDA-Approved Nano-Drug: Lessons Learned. Journal of Controlled Release, 160, 117-134.
https://doi.org/10.1016/j.jconrel.2012.03.020
[86]  Turnbull, I.C., Eltoukhy, A.A., Fish, K.M., Hajjar, R.J., Anderson, D.G. and Costa, K.D. (2013) Abstract 18088: Myocardial Delivery of Lipidoid Nanoparticle mRNA Designed for Tailored Expression of Cardiogenic Factors. Circulation, 128, 128.
https://doi.org/10.1161/circ.128.suppl_22.a18088
[87]  Conway, A., Mendel, M., Kim, K., McGovern, K., Boyko, A., Zhang, L., et al. (2019) Non-Viral Delivery of Zinc Finger Nuclease mRNA Enables Highly Efficient in Vivo Genome Editing of Multiple Therapeutic Gene Targets. Molecular Therapy, 27, 866-877.
https://doi.org/10.1016/j.ymthe.2019.03.003
[88]  Joo, S., Song, Y., Park, Y., Myung, E., Chung, C., Park, K., et al. (2012) Epigallocatechin-3-Gallate Inhibits LPS-Induced NF-κB and MAPK Signaling Pathways in Bone Marrow-Derived Macrophages. Gut and Liver, 6, 188-196.
https://doi.org/10.5009/gnl.2012.6.2.188
[89]  He, Y., Hara, H. and Núñez, G. (2016) Mechanism and Regulation of NLRP3 Inflammasome Activation. Trends in Biochemical Sciences, 41, 1012-1021.
https://doi.org/10.1016/j.tibs.2016.09.002
[90]  Duewell, P., Kono, H., Rayner, K.J., Sirois, C.M., Vladimer, G., Bauernfeind, F.G., et al. (2010) NLRP3 Inflammasomes Are Required for Atherogenesis and Activated by Cholesterol Crystals. Nature, 464, 1357-1361.
https://doi.org/10.1038/nature08938
[91]  Zhang, M., Viennois, E., Prasad, M., Zhang, Y., Wang, L., Zhang, Z., et al. (2016) Edible Ginger-Derived Nanoparticles: A Novel Therapeutic Approach for the Prevention and Treatment of Inflammatory Bowel Disease and Colitis-Associated Cancer. Biomaterials, 101, 321-340.
https://doi.org/10.1016/j.biomaterials.2016.06.018
[92]  Liu, B., Lu, Y., Chen, X., Muthuraj, P.G., Li, X., Pattabiraman, M., et al. (2020) Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice. Nutrients, 12, Article 477.
https://doi.org/10.3390/nu12020477
[93]  Liu, B., Li, X., Yu, H., Shi, X., Zhou, Y., Alvarez, S., et al. (2021) Therapeutic Potential of Garlic Chive-Derived Vesicle-Like Nanoparticles in NLRP3 Inflammasome-Mediated Inflammatory Diseases. Theranostics, 11, 9311-9330.
https://doi.org/10.7150/thno.60265
[94]  Levchenko, T.S., Hartner, W.C. and Torchilin, V.P. (2012) Liposomes in Diagnosis and Treatment of Cardiovascular Disorders. Methodist DeBakey Cardiovascular Journal, 8, 36-41.
https://doi.org/10.14797/mdcj-8-1-36
[95]  Chen, J., Song, Y., Wang, Q., Li, Q., Tan, H., Gao, J., et al. (2022) Targeted Neutrophil-Mimetic Liposomes Promote Cardiac Repair by Adsorbing Proinflammatory Cytokines and Regulating the Immune Microenvironment. Journal of Nanobiotechnology, 20, Article No. 218.
https://doi.org/10.1186/s12951-022-01433-6
[96]  Brito, L.A., Chandrasekhar, S., Little, S.R. and Amiji, M.M. (2010) Non-Viral Gene Delivery Using Self-Assembled Multi-Component (SAMC) Nanoparticles. Journal of Biomedical Materials Research Part A: An Official Journal of the Society for Biomaterials, the Japanese Society for Biomaterials, and the Australian Society for Bio-materials and the Korean Society for Biomaterials, 93, 325-336.
[97]  Bertrand, N., Bouvet, C., Moreau, P. and Leroux, J. (2010) Transmembrane pH-Gradient Liposomes to Treat Cardiovascular Drug Intoxication. ACS Nano, 4, 7552-7558.
https://doi.org/10.1021/nn101924a
[98]  Wrobeln, A., Schlüter, K.D., Linders, J., Zähres, M., Mayer, C., Kirsch, M., et al. (2017) Functionality of Albumin-Derived Perfluorocarbon-Based Artificial Oxygen Carriers in the Langendorff-Heart. Artificial Cells, Nanomedicine, and Biotechnology, 45, 723-730.
https://doi.org/10.1080/21691401.2017.1284858
[99]  Ayyagari, A.L., Zhang, X., Ghaghada, K.B., Annapragada, A., Hu, X. and Bellamkonda, R.V. (2006) Long-Circulating Liposomal Contrast Agents for Magnetic Resonance Imaging. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 55, 1023-1029.
https://doi.org/10.1002/mrm.20846
[100]  Zhang, S., Gao, C., Lü, S., He, J., Liu, M., Wu, C., et al. (2017) Synthesis of Pegylated Polyglutamic Acid Peptide Dendrimer and Its Application in Dissolving Thrombus. Colloids and Surfaces B: Biointerfaces, 159, 284-292.
https://doi.org/10.1016/j.colsurfb.2017.08.009
[101]  Din, F.u., Aman, W., Ullah, I., Qureshi, O.S., Mustapha, O., Shafique, S., et al. (2017) Effective Use of Nanocarriers as Drug Delivery Systems for the Treatment of Selected Tumors. International Journal of Nanomedicine, 12, 7291-7309.
https://doi.org/10.2147/ijn.s146315
[102]  Pinzaru, I., Coricovac, D., Dehelean, C., Moacă, E., Mioc, M., Baderca, F., et al. (2018) Stable Peg-Coated Silver Nanoparticles—A Comprehensive Toxicological Profile. Food and Chemical Toxicology, 111, 546-556.
https://doi.org/10.1016/j.fct.2017.11.051
[103]  Corsi, I., Venditti, I., Trotta, F. and Punta, C. (2023) Environmental Safety of Nanotechnologies: The Eco-Design of Manufactured Nanomaterials for Environmental Remediation. Science of The Total Environment, 864, Article ID: 161181.
https://doi.org/10.1016/j.scitotenv.2022.161181
[104]  Yoo-Iam, M., Chaichana, R. and Satapanajaru, T. (2014) Toxicity, Bioaccumulation and Biomagnification of Silver Nanoparticles in Green Algae (Chlorella sp.), Water Flea (Moina macrocopa), Blood Worm (Chironomus spp.) and Silver Barb (Barbonymus gonionotus). Chemical Speciation & Bioavailability, 26, 257-265.
https://doi.org/10.3184/095422914x14144332205573
[105]  Rani, V., Deep, G., Singh, R.K., Palle, K. and Yadav, U.C.S. (2016) Oxidative Stress and Metabolic Disorders: Pathogenesis and Therapeutic Strategies. Life Sciences, 148, 183-193.
https://doi.org/10.1016/j.lfs.2016.02.002
[106]  Vyshnava, S.S., Kanderi, D.K., Panjala, S.P., Pandian, K., Bontha, R.R., Goukanapalle, P.K.R., et al. (2016) Effect of Silver Nanoparticles against the Formation of Biofilm by Pseudomonas aeruginosa an in Silico Approach. Applied Biochemistry and Biotechnology, 180, 426-437.
https://doi.org/10.1007/s12010-016-2107-7
[107]  Atale, N., Saxena, S., Nirmala, J.G., Narendhirakannan, R., Mohanty, S. and Rani, V. (2016) Synthesis and Characterization of Sygyzium Cumini Nanoparticles for Its Protective Potential in High Glucose-Induced Cardiac Stress: A Green Approach. Applied Biochemistry and Biotechnology, 181, 1140-1154.
https://doi.org/10.1007/s12010-016-2274-6
[108]  Veeresham, C. (2012) Natural Products Derived from Plants as a Source of Drugs. Journal of Advanced Pharmaceutical Technology & Research, 3, 200-201.
https://doi.org/10.4103/2231-4040.104709
[109]  Atale, N., Gupta, K. and Rani, V. (2014) Protective Effect of Syzygium cumini against Pesticide-Induced Cardiotoxicity. Environmental Science and Pollution Research, 21, 7956-7972.
https://doi.org/10.1007/s11356-014-2684-3
[110]  Yadi, M., Mostafavi, E., Saleh, B., Davaran, S., Aliyeva, I., Khalilov, R., et al. (2018) Current Developments in Green Synthesis of Metallic Nanoparticles Using Plant Extracts: A Review. Artificial Cells, Nanomedicine, and Biotechnology, 46, 336-343.
https://doi.org/10.1080/21691401.2018.1492931
[111]  Rasheed, T., Bilal, M., Iqbal, H.M.N. and Li, C. (2017) Green Biosynthesis of Silver Nanoparticles Using Leaves Extract of Artemisia Vulgaris and Their Potential Biomedical Applications. Colloids and Surfaces B: Biointerfaces, 158, 408-415.
https://doi.org/10.1016/j.colsurfb.2017.07.020
[112]  Zheng, M., Huang, Z., Ji, H., Qiu, F., Zhao, D., Bredar, A.R.C., et al. (2020) Simultaneous Control of Soil Erosion and Arsenic Leaching at Disturbed Land Using Polyacrylamide Modified Magnetite Nanoparticles. Science of the Total Environment, 702, 134997.
https://doi.org/10.1016/j.scitotenv.2019.134997
[113]  Vickers, N.J. (2017) Animal Communication: When I’m Calling You, Will You Answer Too? Current Biology, 27, R713-R715.
https://doi.org/10.1016/j.cub.2017.05.064
[114]  Xiu, J., Zhang, Y., Paray, B.A., Gulnaz, A. and War, M.U.D. (2022) Facile Preparation of Fe2O3 Nanoparticles Mediated by Centaurea alba Extract and Assessment of the Anti-Atherosclerotic Properties. Arabian Journal of Chemistry, 15, Article ID: 103493.
https://doi.org/10.1016/j.arabjc.2021.103493
[115]  Mosaddegh, M., Tavakoli, M. and Behzad, S. (2018) Constituents of the Aerial Parts of Centaurea behen. Chemistry of Natural Compounds, 54, 1015-1017.
https://doi.org/10.1007/s10600-018-2539-0
[116]  Öksüz, S. and Ayyildiz, H. (1986) Sesquiterpene Lactones from Centaurea Coronopifolia. Phytochemistry, 25, 535-537.
https://doi.org/10.1016/s0031-9422(00)85520-x
[117]  Oksuz, S., Ulubelen, A., Aynechi, Y. and Wagner, H. (1982) A guaianolide from Centaurea behen. Phytochemistry, 21, 2747-2749.
https://doi.org/10.1016/0031-9422(82)83116-6
[118]  Esmaeili, A., Mousavi, Z., Shokrollahi, M. and Shafaghat, A. (2012) Antioxidant Activity and Isolation of Luteoline from Centaurea behen L. Grown in Iran. Journal of Chemistry, 2013, Article ID: 620305.
https://doi.org/10.1155/2013/620305
[119]  Harper, D. (2002) Talking about Pictures: A Case for Photo Elicitation. Visual Studies, 17, 13-26.
https://doi.org/10.1080/14725860220137345
[120]  Ghashghaii, A., Hashemnia, M., Nikousefat, Z., Zangeneh, M.M. and Zangeneh, A. (2017) Wound Healing Potential of Methanolic Extract of Scrophularia striata in Rats. Pharmaceutical Sciences, 23, 256-263.
https://doi.org/10.15171/ps.2017.38
[121]  Adams, R.P. (2017) Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry (ed. 4.1). Allured Publ Crop.
[122]  Akiyama, H., Ito, A., Sato, M., Kawabe, Y. and Kamihira, M. (2010) Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique. International Journal of Molecular Sciences, 11, 2910-2920.
https://doi.org/10.3390/ijms11082910
[123]  Mou, Y., Zhou, J., Xiong, F., Li, H., Sun, H., Han, Y., et al. (2015) Effects of 2,3-Dimercaptosuccinic Acid Modified Fe2O3 Nanoparticles on Microstructure and Biological Activity of Cardiomyocytes. RSC Advances, 5, 19493-19501.
https://doi.org/10.1039/c4ra11079j
[124]  Sapir, Y., Cohen, S., Friedman, G. and Polyak, B. (2012) The Promotion of in Vitro Vessel-Like Organization of Endothelial Cells in Magnetically Responsive Alginate Scaffolds. Biomaterials, 33, 4100-4109.
https://doi.org/10.1016/j.biomaterials.2012.02.037
[125]  Han, J., Kim, B., Shin, J., Ryu, S., Noh, M., Woo, J., et al. (2015) Iron Oxide Nanoparticle-Mediated Development of Cellular Gap Junction Crosstalk to Improve Mesenchymal Stem Cells’ Therapeutic Efficacy for Myocardial Infarction. ACS Nano, 9, 2805-2819.
https://doi.org/10.1021/nn506732n
[126]  Hussein, J., El-Banna, M., Razik, T.A. and El-Naggar, M.E. (2018) Biocompatible Zinc Oxide Nanocrystals Stabilized via Hydroxyethyl Cellulose for Mitigation of Diabetic Complications. International Journal of Biological Macromolecules, 107, 748-754.
https://doi.org/10.1016/j.ijbiomac.2017.09.056
[127]  Teixeira, B.C., Lopes, A.L., Macedo, R.C.O., Correa, C.S., Ramis, T.R., Ribeiro, J.L., et al. (2014) Inflammatory Markers, Endothelial Function and Cardiovascular Risk. Jornal Vascular Brasileiro, 13, 108-115.
https://doi.org/10.1590/jvb.2014.054
[128]  Alshehri, M.A. (2022) Cardioprotective Properties of Artemisia Herba Alba Nanoparticles against Heart Attack in Rats: A Study of the Antioxidant and Hypolipidemic Activities. Saudi Journal of Biological Sciences, 29, 2336-2347.
https://doi.org/10.1016/j.sjbs.2021.12.009
[129]  Radulović, N.S., Randjelović, P.J., Stojanović, N.M., Blagojević, P.D., Stojanović-Radić, Z.Z., Ilić, I.R., et al. (2013) Toxic Essential Oils. Part II: Chemical, Toxicological, Pharmacological and Microbiological Profiles of Artemisia annua L. Volatiles. Food and Chemical Toxicology, 58, 37-49.
https://doi.org/10.1016/j.fct.2013.04.016
[130]  Skowyra, M., Gallego, M., Segovia, F. and Almajano, M. (2014) Antioxidant Properties of Artemisia annua Extracts in Model Food Emulsions. Antioxidants, 3, 116-128.
https://doi.org/10.3390/antiox3010116
[131]  Acikel, M., Buyukokuroglu, M.E., Erdogan, F., Aksoy, H., Bozkurt, E. and Senocak, H. (2005) Protective Effects of Dantrolene against Myocardial Injury Induced by Isoproterenol in Rats: Biochemical and Histological Findings. International Journal of Cardiology, 98, 389-394.
https://doi.org/10.1016/j.ijcard.2003.10.054
[132]  Shalyapina, A.Y., Solovyova, A.Y., Zaporozhets, M.A., Khokhlov, E.M., Plot-nichenko, V.G., Buslaeva, E.Y., Rustamova, E.G. and Gubin, S.P. (2012) Composite Materials Based on Graphene and Zinc Oxide Nanoparticles. Fine Chemical Technologies, 7, 80-84. (In Russian)
[133]  El-Sayed, M.A. (2001) Some Interesting Properties of Metals Confined in Time and Nanometer Space of Different Shapes. Accounts of Chemical Research, 34, 257-264.
https://doi.org/10.1021/ar960016n
[134]  Ibrar, M., Khan, M.A., Abdullah, and Imran, M. (2018) Evaluation of Paeonia Emodi and Its Gold Nanoparticles for Cardioprotective and Antihyperlipidemic Potentials. Journal of Photochemistry and Photobiology B: Biology, 189, 5-13.
https://doi.org/10.1016/j.jphotobiol.2018.09.018
[135]  Dreaden, E.C., Austin, L.A., Mackey, M.A. and El-Sayed, M.A. (2012) Size Matters: Gold Nanoparticles in Targeted Cancer Drug Delivery. Therapeutic Delivery, 3, 457-478.
https://doi.org/10.4155/tde.12.21
[136]  Zhang, T., Dang, M., Zhang, W. and Lin, X. (2020) Gold Nanoparticles Synthesized from Euphorbia fischeriana Root by Green Route Method Alleviates the Isoprenaline Hydrochloride Induced Myocardial Infarction in Rats. Journal of Photochemistry and Photobiology B: Biology, 202, Article ID: 111705.
https://doi.org/10.1016/j.jphotobiol.2019.111705
[137]  Shiny, K.S., Kumar, S.H.S., Farvin, K.H.S., Anandan, R. and Devadasan, K. (2005) Protective Effect of Taurine on Myocardial Antioxidant Status in Isoprenaline-Induced Myocardial Infarction in Rats. Journal of Pharmacy and Pharmacology, 57, 1313-1317.
https://doi.org/10.1211/jpp.57.10.0010
[138]  Vinodhini, A., Govindaraju, K., Singaravelu, G., Mohamed Sadiq, A. and Kumar, V.G. (2014) Cardioprotective Potential of Biobased Gold Nanoparticles. Colloids and Surfaces B: Biointerfaces, 117, 480-486.
https://doi.org/10.1016/j.colsurfb.2014.01.006
[139]  Karthikeyan, K., Sarala Bai, B.R., Gauthaman, K., Sathish, K.S. and Devaraj, S.N. (2003) Cardioprotective Effect of the Alcoholic Extract of Terminalia Arjuna Bark in an in Vivo Model of Myocardial Ischemic Reperfusion Injury. Life Sciences, 73, 2727-2739.
https://doi.org/10.1016/s0024-3205(03)00671-4
[140]  Liu, Y., Guo, J., Zhou, Z., Wu, Q., Jin, X. and Wang, T. (2023) Protective Properties of Nanoparticles Green-Synthesized by Plant on Myocardial Ischemia. Inorganic Chemistry Communications, 154, Article ID: 110902.
https://doi.org/10.1016/j.inoche.2023.110902
[141]  Ritchie, R.H. and Abel, E.D. (2020) Basic Mechanisms of Diabetic Heart Disease. Circulation Research, 126, 1501-1525.
https://doi.org/10.1161/circresaha.120.315913
[142]  Hao, W., Jia, Y., Wang, C. and Wang, X. (2022) Preparation, Chemical Characterization and Determination of the Antioxidant, Cytotoxicity and Therapeutic Effects of Gold Nanoparticles Green-Synthesized by Calendula Officinalis Flower Extract in Diabetes-Induced Cardiac Dysfunction in Rat. Inorganic Chemistry Communications, 144, Article ID: 109931.
https://doi.org/10.1016/j.inoche.2022.109931
[143]  Yadid, M., Feiner, R. and Dvir, T. (2019) Gold Nanoparticle-Integrated Scaffolds for Tissue Engineering and Regenerative Medicine. Nano Letters, 19, 2198-2206.
https://doi.org/10.1021/acs.nanolett.9b00472
[144]  Hassan, H., Sharma, P., Hasan, M.R., Singh, S., Thakur, D. and Narang, J. (2022) Gold Nanomaterials—The Golden Approach from Synthesis to Applications. Materials Science for Energy Technologies, 5, 375-390.
https://doi.org/10.1016/j.mset.2022.09.004
[145]  Wei, X., Jiang, X. and Li, H. (2024) Fundamental Characteristics of Ultrasonic Green Formulations Using Avena sativa L. Extract-Mediated Gold Nanoparticles and Electroconductive Nanofibers for Cardiovascular Nursing Care. Heliyon, 10, e35018.
https://doi.org/10.1016/j.heliyon.2024.e35018
[146]  Bala, I., Bhardwaj, V., Hariharan, S. and Kumar, M.N.V.R. (2006) Analytical Methods for Assay of Ellagic Acid and Its Solubility Studies. Journal of Pharmaceutical and Biomedical Analysis, 40, 206-210.
https://doi.org/10.1016/j.jpba.2005.07.006
[147]  Yu, X., Wang, J., Wang, T., Song, S., Su, H., Huang, H., et al. (2024) Ellagic Acid-Enhanced Biocompatibility and Bioactivity in Multilayer Core-Shell Gold Nanoparticles for Ameliorating Myocardial Infarction Injury. Journal of Nanobiotechnology, 22, Article No. 554.
https://doi.org/10.1186/s12951-024-02796-8
[148]  Hao, T., Qian, M., Zhang, Y., Liu, Q., Midgley, A.C., Liu, Y., et al. (2022) An Injectable Dual‐function Hydrogel Protects against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium. Advanced Science, 9, Article ID: 2105408.
https://doi.org/10.1002/advs.202105408
[149]  Dong, F., Cui, Z., Teng, G., Shangguan, K., Zhang, Q. and Zhang, G. (2022) Green Synthesis of Gold Nanoparticles (AuNPs) as Potential Drug Carrier for Treatment and Care of Cardiac Hypertrophy Agents. Journal of Cluster Science, 33, 1129-1137.
https://doi.org/10.1007/s10876-021-02003-w
[150]  Alyan, A., Abdel-Samad, S., Massoud, A. and Waly, S.A. (2019) Characterization and Thermal Conductivity Investigation of Copper-Polyaniline Nano Composite Synthesized by Gamma Radiolysis Method. Heat and Mass Transfer, 55, 2409-2417.
https://doi.org/10.1007/s00231-019-02588-z
[151]  Jayakodi, S., Shanmugam, R., Almutairi, B.O., Almutairi, M.H., Mahboob, S., Kavipriya, M.R., et al. (2022) Azadirachta indica-Wrapped Copper Oxide Nanoparticles as a Novel Functional Material in Cardiomyocyte Cells: An Ecotoxicity Assessment on the Embryonic Development of Danio Rerio. Environmental Research, 212, Article ID: 113153.
https://doi.org/10.1016/j.envres.2022.113153
[152]  Vinotha, V., Iswarya, A., Thaya, R., Govindarajan, M., Alharbi, N.S., Kadaikunnan, S., et al. (2019) Synthesis of ZnO Nanoparticles Using Insulin-Rich Leaf Extract: Anti-Diabetic, Antibiofilm and Anti-Oxidant Properties. Journal of Photochemistry and Photobiology B: Biology, 197, Article ID: 111541.
https://doi.org/10.1016/j.jphotobiol.2019.111541
[153]  Sivaraj, R., Rahman, P.K.S.M., Rajiv, P., Narendhran, S. and Venckatesh, R. (2014) Biosynthesis and Characterization of Acalypha indica Mediated Copper Oxide Nanoparticles and Evaluation of Its Antimicrobial and Anticancer Activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 129, 255-258.
https://doi.org/10.1016/j.saa.2014.03.027
[154]  Morgan, E.D. (2009) Azadirachtin, a Scientific Gold Mine. Bioorganic & Medicinal Chemistry, 17, 4096-4105.
https://doi.org/10.1016/j.bmc.2008.11.081
[155]  Ganda, O.P. (2009) Dyslipidemia: Pathogenesis and Management. In: Poretsky, L., Ed., Principles of Diabetes Mellitus, Springer US, 435-456.
https://doi.org/10.1007/978-0-387-09841-8_28
[156]  Hajar, R. (2017) Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views, 18, 109-114.
https://doi.org/10.4103/heartviews.heartviews_106_17
[157]  Qu, S., Han, X. and Yu, Y. (2024) Protective Effects of Copper Nanoparticles Green-Formulated by Ginkgo biloba Leaf Extract on Cardiac Function in Obese Insulin-Resistant Rats. Inorganic Chemistry Communications, 162, Article ID: 112204.
https://doi.org/10.1016/j.inoche.2024.112204
[158]  Swamy, A., Gulliaya, S., Thippeswamy, A., Koti, B. and Manjula, D. (2012) Cardioprotective Effect of Curcumin against Doxorubicin-Induced Myocardial Toxicity in Albino Rats. Indian Journal of Pharmacology, 44, 73-77.
https://doi.org/10.4103/0253-7613.91871
[159]  Yadav, Y.C., Pattnaik, S. and Swain, K. (2019) Curcumin Loaded Mesoporous Silica Nanoparticles: Assessment of Bioavailability and Cardioprotective Effect. Drug Development and Industrial Pharmacy, 45, 1889-1895.
https://doi.org/10.1080/03639045.2019.1672717
[160]  M Luisa, D.P., Griselda, R., Valentín, M., Carmina, O., Cristina, V., JJ, M., et al. (2020) Curcumin-Loaded Poly-ε-Caprolactone Nanoparticles Show Antioxidant and Cytoprotective Effects in the Presence of Reactive Oxygen Species. Journal of Bioactive and Compatible Polymers, 35, 270-285.
https://doi.org/10.1177/0883911520921499
[161]  Cheng, J., Ding, Q., Wang, J., Deng, L., Yang, L., Tao, L., et al. (2016) 5-Azacytidine Delivered by Mesoporous Silica Nanoparticles Regulates the Differentiation of P19 Cells into Cardiomyocytes. Nanoscale, 8, 2011-2021.
https://doi.org/10.1039/c5nr08560h
[162]  Ren, M., Han, Z., Li, J., Feng, G. and Ouyang, S. (2015) Ascorbic Acid Delivered by Mesoporous Silica Nanoparticles Induces the Differentiation of Human Embryonic Stem Cells into Cardiomyocytes. Materials Science and Engineering: C, 56, 348-355.
https://doi.org/10.1016/j.msec.2015.06.048
[163]  Ramezani Farani, M., Farsadrooh, M., Zare, I., Gholami, A. and Akhavan, O. (2023) Green Synthesis of Magnesium Oxide Nanoparticles and Nanocomposites for Photocatalytic Antimicrobial, Antibiofilm and Antifungal Applications. Catalysts, 13, Article 642.
https://doi.org/10.3390/catal13040642
[164]  Nisa, F.Y., Rahman, M.A., Rafi, M.K.J., Khan, M.A.N., Sultana, F., Majid, M., et al. (2023) Biosynthesized Magnesium Oxide Nanoparticles from Tamarindus indica Seed Attenuate Doxorubicin-Induced Cardiotoxicity by Regulating Biochemical Indexes and Linked Genes. Biomaterials Advances, 146, Article ID: 213291.
https://doi.org/10.1016/j.bioadv.2023.213291
[165]  Venkatappa, M.M., Udagani, C., Hanumegowda, S.M., Pramod, S.N., et al. (2022) Effect of Biofunctional Green Synthesized Mgo-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis. Molecules, 27, Article 5162.
https://doi.org/10.3390/molecules27165162

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