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中药活性成分靶向肿瘤细胞铁死亡的分子机制研究
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Abstract:
铁死亡是近年来肿瘤治疗领域的热门研究，是一种程序性的铁依赖性细胞死亡方式。中药活性成分具有多靶点、低毒性等优势，可通过多种途径调控铁死亡相关通路，诱导肿瘤细胞铁死亡。本文综述铁死亡的分子机制，探讨其在肿瘤治疗中的潜在应用价值，为新型抗肿瘤药物的开发提供理论依据，并对铁死亡通路抑制肿瘤的中药活性成分靶向的最新研究进展进行了深入的研究。
Ferroptosis is a hot topic in cancer treatment research in recent years, representing a programmed iron-dependent form of cell death. Active ingredients in traditional Chinese medicine (TCM) offer advantages such as multi-target effects and low toxicity, and can regulate ferroptosis-related pathways through various mechanisms to induce ferroptosis in cancer cells. This review summarizes the molecular mechanisms of ferroptosis, explores its potential applications in cancer therapy, provides a theoretical foundation for the development of novel anti-cancer drugs, and delves into the latest research progress on targeting ferroptosis pathways with active ingredients from TCM to suppress tumors.
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