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药物球囊应用于支架内再狭窄患者临床疗效研究进展
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Abstract:
支架内再狭窄(In-Stent Restenosis, ISR)是冠状动脉介入治疗后常见且具有挑战性的并发症，严重影响患者的长期预后和生活质量。随着介入技术的发展，药物球囊(Drug-Coated Balloon, DCB)作为一种新兴的局部药物递送工具，因其无需再次植入支架且能有效抑制血管内膜增生，近年来在ISR治疗领域受到广泛关注与研究。当前大量临床试验和系统评价显示，药物球囊在改善血管通畅率、减少再狭窄发生及降低不良心血管事件方面表现出良好的临床疗效和安全性。然而，药物球囊的作用机制尚需进一步阐明，且不同患者群体的疗效差异及长期效果仍有待深入探讨。本综述着重药物球囊在ISR患者中的最新应用进展，系统分析其临床疗效与安全性评价，并对未来的研究方向进行了展望，旨在为临床治疗提供科学依据和实践指导，推动ISR治疗策略的优化升级。
In-Stent Restenosis, ISR) is a common and challenging complication after percutaneous coronary intervention, which seriously affects the long-term prognosis and quality of life of patients. With the development of interventional technology, Drug-Coated Balloon, DCB), as a new local drug delivery tool, has been widely concerned and studied in the field of ISR therapy in recent years because it does not need to implant stents again and can effectively inhibit intimal hyperplasia. At present, a large number of clinical trials and systematic reviews show that drug balloons show good clinical efficacy and safety in improving vascular patency rate, reducing restenosis and reducing adverse vascular events. However, the mechanism of action of drug balloon needs to be further clarified, and the difference of curative effect and long-term effect of different patient groups need to be further discussed. This review focuses on the latest application progress of drug balloon in ISR patients, systematically analyzes its clinical efficacy and safety evaluation, and looks forward to the future research direction, aiming at providing scientific basis and practical guidance for clinical treatment and promoting the optimization and upgrading of ISR treatment strategy.
| [1] | Kawai, K., Virmani, R. and Finn, A.V. (2022) In-Stent Restenosis. Interventional Cardiology Clinics, 11, 429-443. https://doi.org/10.1016/j.iccl.2022.02.005 |
| [2] | Sartore, L., Gitto, M., Oliva, A., Kakizaki, R., Mehran, R., Räber, L., et al. (2024) Recent Advances in the Treatment of Coronary In-Stent Restenosis. Reviews in Cardiovascular Medicine, 25, Article 433. https://doi.org/10.31083/j.rcm2512433 |
| [3] | Zhu, G., Wang, S., Liu, Z., Gu, S., Chen, F. and Zang, W. (2025) Chlorogenic Acid-Strontium-Containing Dual-Functional Bioresorbable External Stent Suppresses Venous Graft Restenosis via Hippo-YAP Signaling Pathway. Journal of Functional Biomaterials, 16, Article 259. https://doi.org/10.3390/jfb16070259 |
| [4] | Chen, Q., Sun, S., Shi, Z., Wang, L., Wang, Y., Zheng, A., et al. (2025) Novel Roles of Nrf3-Trim5 Axis in Vascular Smooth Muscle Cell Dysfunctions and Neointimal Hyperplasia. Cardiovascular Research, 121, 1282-1298. https://doi.org/10.1093/cvr/cvaf084 |
| [5] | Wierer, M., Werner, J., Wobst, J., Kastrati, A., Cepele, G., Aherrahrou, R., et al. (2021) A Proteomic Atlas of the Neointima Identifies Novel Druggable Targets for Preventive Therapy. European Heart Journal, 42, 1773-1785. https://doi.org/10.1093/eurheartj/ehab140 |
| [6] | Kulyassa, P.M., Németh, B.T., Hizoh, I., Jankó, L.K., Ruzsa, Z., Jambrik, Z., et al. (2025) The Design and Feasibility of Optimal Treatment for Coronary Drug-Eluting Stent In-Stent Restenosis (OPEN-ISR)—A Prospective, Randomised, Multicentre Clinical Trial. Journal of Personalized Medicine, 15, Article 60. https://doi.org/10.3390/jpm15020060 |
| [7] | Oli, P.R., Shrestha, D.B., Dawadi, S., Poudel, S., Ali, F., Shtembari, J., et al. (2025) Comparison of Different PCI Strategies for Coronary DES In-Stent Restenosis: A Bayesian Network Meta-Analysis. Journal of the Society for Cardiovascular Angiography & Interventions, 4, Article 102428. https://doi.org/10.1016/j.jscai.2024.102428 |
| [8] | Cuesta, J., Pérez-Vizcayno, M.J., García del Blanco, B., Bosa, F., Pérez de Prado, A., Rumoroso, J.R., et al. (2024) Long-Term Results of Bioresorbable Vascular Scaffolds in Patients with In-Stent Restenosis: The RIBS VI Stud. JACC: Cardiovascular Interventions, 17, 1825-1836. https://doi.org/10.1016/j.jcin.2024.05.038 |
| [9] | Sikora-Jasinska, M., Morath, L.M., Kwesiga, M.P., Plank, M.E., Nelson, A.L., Oliver, A.A., et al. (2022) In-Vivo Evaluation of Molybdenum as Bioabsorbable Stent Candidate. Bioactive Materials, 14, 262-271. https://doi.org/10.1016/j.bioactmat.2021.11.005 |
| [10] | Gąsecka, A., Pindlowski, P., Szczerba, M., Zimodro, J.M., Błażejowska, E., Pietrasik, A., et al. (2025) Drug-Coated Balloons in Percutaneous Coronary Interventions: Existing Evidence and Emerging Hopes. Cardiology Journal, 32, 308-320. https://doi.org/10.5603/cj.101393 |
| [11] | Chioncel, V., Gherasie, F., Iancu, A. and Avram, A. (2025) Coronary Angioplasty with Drug-Coated Balloons: Pharmacological Foundations, Clinical Efficacy, and Future Directions. Medicina, 61, Article 1470. https://doi.org/10.3390/medicina61081470 |
| [12] | Mitsutake, Y., Konishi, A., Shiba, T., Ito, T., Ho, M. and Shirato, H. (2021) Differences in Clinical Outcomes between Pre-and Post-Marketing Clinical Study Following Paclitaxel-Coated Balloon Catheter Treatment for Coronary In-Stent Restenosis: From the Japanese Regulatory Viewpoint. Heart and Vessels, 36, 155-162. https://doi.org/10.1007/s00380-020-01676-z |
| [13] | Galli, S., Troiano, S., Tespili, M., Ielasi, A., Niccoli, G., Sommariva, L., et al. (2021) Results of Paclitaxel-Drug-Coated Balloons (Pantera Lux) for Coronary In-Stent Restenosis: Italian Experience from Registry of Paclitaxel Eluting Balloon in ISR Study. Journal of Cardiovascular Medicine, 22, 469-477. https://doi.org/10.2459/jcm.0000000000001127 |
| [14] | Cai, X., Zhou, S., Cai, X., Gao, L., Tian, F., Jing, J., et al. (2023) Comparing the Efficacy and Safety of Two Different Drug-Coated Balloons in In-Stent Restenosis: Two-Year Clinical Outcomes of the RESTORE ISR China Randomized Trial. Journal of Cardiology, 81, 76-82. https://doi.org/10.1016/j.jjcc.2022.08.014 |
| [15] | Giacoppo, D., Alfonso, F., Xu, B., Claessen, B.E.P.M., Adriaenssens, T., Jensen, C., et al. (2020) Drug-Coated Balloon Angioplasty versus Drug-Eluting Stent Implantation in Patients with Coronary Stent Restenosis. Journal of the American College of Cardiology, 75, 2664-2678. https://doi.org/10.1016/j.jacc.2020.04.006 |
| [16] | Gherasie, F.A., Ciomag Ianula, R. and Gherasie, L. (2025) Drug-Coated Balloon PCI in Different Plaque Morphologies: A Narrative Review. Biomedicines, 13, Article 1472. https://doi.org/10.3390/biomedicines13061472 |
| [17] | Matteucci, A., Benedetto, D., Bonanni, M., Massaro, G., Russo, D., Russo, G., et al. (2023) Rationale and Design of the Sirolimus Eluting Balloon Utilization for Treatment of Vasculogenic Erectile Dysfunction: The SUASION Registry. Minerva Cardiology and Angiology, 71, 349-358. https://doi.org/10.23736/s2724-5683.22.06039-2 |
| [18] | Cao, Z., Li, J., Fang, Z., Feierkaiti, Y., Zheng, X. and Jiang, X. (2022) The Factors Influencing the Efficiency of Drug-Coated Balloons. Frontiers in Cardiovascular Medicine, 9, Article 947776. https://doi.org/10.3389/fcvm.2022.947776 |
| [19] | Han, Y., Yuan, X., Wang, W., Wang, N., Zhang, Y., Jing, J., et al. (2024) Clinical Significance of Optical Coherence Tomography-Guided Percutaneous Coronary Intervention for In-Stent Restenosis within Drug-Eluting Stents: Impact on Patient Outcomes. Journal of the American Heart Association, 13, e033954. https://doi.org/10.1161/jaha.123.033954 |
| [20] | Pradhan, A., Roy, S., Chaudhary, G., Vishwakarma, P., Chandra, S. and Hasibuzzaman, M.A. (2023) A Tale of Two in Stent Restenosis in Same Patient: Surprising Findings from Optical Coherence Tomography. Clinical Case Reports, 11, e8222. https://doi.org/10.1002/ccr3.8222 |
| [21] | Saboe, A., Upadhya, C., Finn, A. and Basavarajaiah, S. (2025) Coronary Artery Aneurysm Post Drug-Coated Balloon Angioplasty. JACC: Case Reports, 30, Article 103891. https://doi.org/10.1016/j.jaccas.2025.103891 |
| [22] | Tran, A. and Dear, A.E. (2025) Advances in Drug-Eluting Angioplasty Balloon Coatings, Clinical Implications and Future Directions: A Mini Review. Current Vascular Pharmacology, 23, 33-42. https://doi.org/10.2174/0115701611369472250526044344 |
| [23] | Ng, J.C.K., Toong, D.W.Y., Ow, V., Chaw, S.Y., Toh, H., Wong, P.E.H., et al. (2022) Progress in Drug-Delivery Systems in Cardiovascular Applications: Stents, Balloons and Nanoencapsulation. Nanomedicine, 17, 325-347. https://doi.org/10.2217/nnm-2021-0288 |
| [24] | Shazly, T., Eberth, J.F., Kostelnik, C.J., Uline, M.J., Chitalia, V.C., Spinale, F.G., et al. (2024) Hydrophilic Coating Microstructure Mediates Acute Drug Transfer in Drug-Coated Balloon Therapy. ACS Applied Bio Materials, 7, 3041-3049. https://doi.org/10.1021/acsabm.4c00080 |
| [25] | Zhao, J., Jia, F., Li, J., Tao, Y., Hu, J., Ren, K., et al. (2025) Sprayable Reactive Oxygen Species-Responsive Hydrogel Coatings Restore Endothelial Barrier Integrity for Functional Vascular Healing. ACS Nano, 19, 21757-21774. https://doi.org/10.1021/acsnano.5c05477 |
| [26] | Lee, K., Lee, J., Lee, S.G., Park, S., Yang, D.S., Lee, J., et al. (2020) Microneedle Drug Eluting Balloon for Enhanced Drug Delivery to Vascular Tissue. Journal of Controlled Release, 321, 174-183. https://doi.org/10.1016/j.jconrel.2020.02.012 |
| [27] | Zhang, X., Cheng, Y., Liu, R. and Zhao, Y. (2022) Globefish-Inspired Balloon Catheter with Intelligent Microneedle Coating for Endovascular Drug Delivery. Advanced Science, 9, e2204497. https://doi.org/10.1002/advs.202204497 |
| [28] | Hong, S. and Hong, M. (2022) Drug-Eluting Stents for the Treatment of Coronary Artery Disease: A Review of Recent Advances. Expert Opinion on Drug Delivery, 19, 269-280. https://doi.org/10.1080/17425247.2022.2044784 |
| [29] | Moumneh, M.B., Jamil, Y., Nanna, M.G. and Damluji, A.A. (2025) Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice. Current Treatment Options in Cardiovascular Medicine, 27, e10370. https://doi.org/10.1007/s11936-025-01084-4 |
| [30] | Shazly, T., Torres, W.M., Secemsky, E.A., Chitalia, V.C., Jaffer, F.A. and Kolachalama, V.B. (2023) Understudied Factors in Drug-Coated Balloon Design and Evaluation: A Biophysical Perspective. Bioengineering & Translational Medicine, 8, e10370. https://doi.org/10.1002/btm2.10370 |
| [31] | Guo, Z., Guo, J., Wu, S., Zhang, F., Gao, X. and Guo, L. (2024) Comparative Efficacy and Safety of Different Balloon Angioplasty Procedures for Infrapopliteal Artery Lesions in Chronic Limb-Threatening Ischemia Patients: A Systematic Review and Network Meta-Analysis. Journal of Endovascular Therapy. https://doi.org/10.1177/15266028241292954 |
| [32] | Jeger, R.V., Eccleshall, S., Wan Ahmad, W.A., et al. (2020) Drug-Coated Balloons for Coronary Artery Disease: Third Report of the International DCB Consensus Group. JACC: Cardiovascular Interventions, 13, 1391-1402. https://doi.org/10.1016/j.jcin.2020.02.043 |
| [33] | Giannopoulos, S., Kokkinidis, D.G., Jawaid, O., Behan, S., Hossain, P., Alvandi, B., et al. (2020) Turbo-Power Laser Atherectomy Combined with Drug-Coated Balloon Angioplasty Is Associated with Improved One-Year Outcomes for the Treatment of Tosaka II and III Femoropopliteal In-Stent Restenosis. Cardiovascular Revascularization Medicine, 21, 771-778. https://doi.org/10.1016/j.carrev.2019.10.006 |
| [34] | Stratakos, E., Antonini, L., Poletti, G., Berti, F., Tzafriri, A.R., Petrini, L., et al. (2023) Investigating Balloon-Vessel Contact Pressure Patterns in Angioplasty: In Silico Insights for Drug-Coated Balloons. Annals of Biomedical Engineering, 51, 2908-2922. https://doi.org/10.1007/s10439-023-03359-y |
| [35] | Farsad, K., Novelli, P.M., Laing, C., Gandhi, R.T., Cynamon, J., López, C.S., et al. (2024) Double-Balloon Catheter-Mediated Transarterial Chemotherapy Delivery in a Swine Model: A Mechanism Recruiting the Vasa Vasorum for Localized Therapies. Journal of Vascular and Interventional Radiology, 35, 1043-1048.e3. https://doi.org/10.1016/j.jvir.2024.03.016 |
| [36] | Zhang, D.M. and Chen, S. (2020) In-Stent Restenosis and a Drug-Coated Balloon: Insights from a Clinical Therapeutic Strategy on Coronary Artery Diseases. Cardiology Research and Practice, 2020, 1-7. https://doi.org/10.1155/2020/8104939 |
| [37] | Li, M., Guo, C., Lv, Y.H., Zhang, M.B. and Wang, Z.L. (2019) Drug-Coated Balloon versus Drug-Eluting Stent in de novo Small Coronary Vessel Disease: A Systematic Review and Meta-Analysis. Medicine (Baltimore), 98, e15622. |
| [38] | Wang, L., Li, X., Li, T., Liu, L., Wang, H. and Wang, C. (2023) Novel Application of Drug-Coated Balloons in Coronary Heart Disease: A Narrative Review. Frontiers in Cardiovascular Medicine, 10, Article 1055274. https://doi.org/10.3389/fcvm.2023.1055274 |
| [39] | Gupta, A., Shrivastava, A., Dugal, J.S., Chhikara, S., Vijayvergiya, R., Singh, N., et al. (2024) Coronary Intravascular Lithotripsy in Contemporary Practice: Challenges and Opportunities in Coronary Intervention. Therapeutic Advances in Cardiovascular Disease, 18, Article 17539447241263444. https://doi.org/10.1177/17539447241263444 |
| [40] | Brunt, E.M., Clouston, A.D., Goodman, Z., Guy, C., Kleiner, D.E., Lackner, C., et al. (2022) Complexity of Ballooned Hepatocyte Feature Recognition: Defining a Training Atlas for Artificial Intelligence-Based Imaging in NAFLD. Journal of Hepatology, 76, 1030-1041. https://doi.org/10.1016/j.jhep.2022.01.011 |
| [41] | Nagasaka, T., Amanai, S., Ishibashi, Y., Aihara, K., Ohyama, Y., Takama, N., et al. (2023) Drug-Coated Balloons for the Treatment of Stent Edge Restenosis. Coronary Artery Disease, 34, 236-243. https://doi.org/10.1097/mca.0000000000001235 |
| [42] | Wang, G., Zhao, Q., Chen, Q., Zhang, X., Tian, L. and Zhang, X. (2019) Comparison of Drug-Eluting Balloon with Repeat Drug-Eluting Stent for Recurrent Drug-Eluting Stent In-Stent Restenosis. Coronary Artery Disease, 30, 473-480. https://doi.org/10.1097/mca.0000000000000784 |
| [43] | Mahajan, N., Singal, G. and Sharma, M. (2025) Comparative Outcomes of Drug Eluting Stents and Drug Eluting Balloons in Treating In-Stent Restenosis. Archives of Medical Science—Atherosclerotic Diseases, 10, 167-171. https://doi.org/10.5114/amsad/210583 |
| [44] | Wang, Q.H., Tang, C., Zhao, B., et al. (2025) Clinical Efficacy of Drug-Coated Balloon vs Plain Balloon in the Treatment of Restenosis after Stenting of Femoropopliteal Artery Occlusive Disease with Complex Long Segment Combined with Severe Calcification. National Medical Journal of China, 105, 1347-1354. |
| [45] | Sabina, M., Rivera-Martinez, J.C., Khanani, A., Rigdon, A., Owen, P. and Massaro, J. (2024) Drug-Coated Balloon Angioplasty vs Plain Balloon Angioplasty in Patients with Coronary In-Stent Restenosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Current Problems in Cardiology, 49, Article 102761. https://doi.org/10.1016/j.cpcardiol.2024.102761 |
| [46] | Guntipalli, M., Obi, O., Jeswin, T.M., Naidoo, R., Ghenai, M.A., Kansara, N., et al. (2025) Drug-Coated Balloons for the Treatment of In-Stent Restenosis: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. Annals of Medicine & Surgery, 87, 5165-5172. https://doi.org/10.1097/ms9.0000000000003496 |
| [47] | von Koch, S., Zhou, M., Rosén, H.C., Zwackman, S., Jurga, J., Grimfjärd, P., et al. (2024) Drug-Coated Balloons versus Drug-Eluting Stents or Plain Old Balloon Angioplasty: A Long-Term In-Stent Restenosis Study. Journal of the American Heart Association, 13, e036869. https://doi.org/10.1161/jaha.124.036839 |
| [48] | Torsello, G., Stavroulakis, K., Brodmann, M., Micari, A., Tepe, G., Veroux, P., et al. (2020) Three-Year Sustained Clinical Efficacy of Drug-Coated Balloon Angioplasty in a Real-World Femoropopliteal Cohort. Journal of Endovascular Therapy, 27, 693-705. https://doi.org/10.1177/1526602820931477 |
| [49] | Ansel, G.M., Brodmann, M., Rocha-Singh, K.J., Menk, J.S. and Zeller, T. (2024) Five-Year Safety and Effectiveness of Paclitaxel Drug-Coated Balloons Alone or with Provisional Bare Metal Stenting for Real-World Femoropopliteal Lesions: IN.PACT Global Study Subgroup Analysis. Circulation: Cardiovascular Interventions, 17, e013084. https://doi.org/10.1161/circinterventions.123.013084 |
| [50] | Ray, S., Bandyopadhyay, S., Bhattacharjee, P., Mukherjee, P., Karmakar, S., Bose, P., et al. (2025) Drug-Coated Balloon in Patients with In-Stent Restenosis: A Prospective Observational Study. Indian Heart Journal, 77, 105-109. https://doi.org/10.1016/j.ihj.2025.03.003 |
| [51] | Pleva, L., Kukla, P., Kovarnik, T. and Zapletalova, J. (2025) Comparing the Efficacy of Sirolimus and Paclitaxel-Eluting Balloon Catheters in the Treatment of Coronary In-Stent Restenosis: A Prospective Randomized Study (TIS 2 Study). Circulation: Cardiovascular Interventions, 18, e014677. https://doi.org/10.1161/circinterventions.124.014677 |
| [52] | Liu, S., Zhou, Y., Shen, Z., Chen, H., Qiu, C., Fu, G., et al. (2023) A Randomized Comparison of 2 Different Drug-Coated Balloons for In-Stent Restenosis. JACC: Cardiovascular Interventions, 16, 759-767. https://doi.org/10.1016/j.jcin.2022.12.018 |
| [53] | Katsouras, C.S., Tousis, A., Vasilagkos, G., Semertzioglou, A., Vratimos, A., Samara, I., et al. (2023) Safety and Efficacy of an Innovative Everolimus-Coated Balloon in a Swine Coronary Artery Model. Life, 13, Article 2053. https://doi.org/10.3390/life13102053 |
| [54] | Krefting, J., Krüger, N., Friess, C., Gräßer, C., Schmieder, R., Starnecker, F., et al. (2025) Clinical Outcomes of Drug-Coated Balloon vs. Second-Generation Drug-Eluting Stent for Coronary In-Stent Restenosis. Clinical Research in Cardiology. https://doi.org/10.1007/s00392-025-02781-7 |
| [55] | Mangner, N., Farah, A., Ohlow, M., Möbius-Winkler, S., Weilenmann, D., Wöhrle, J., et al. (2022) Safety and Efficacy of Drug-Coated Balloons versus Drug-Eluting Stents in Acute Coronary Syndromes: A Prespecified Analysis of BASKET-SMALL 2. Circulation: Cardiovascular Interventions, 15, e011325. https://doi.org/10.1161/circinterventions.121.011325 |
| [56] | Núñez-Castellanos, C.A., Esquinca-Morales, M.F., Beristain-Bolaños, M.C., De León Avecilla, D.I., Aguirre-Ocaña, J.S., Diaz-De-La-Cruz, O.Y., et al. (2024) Comparison of Safety and Efficacy of Femoropopliteal Arterial Disease Using Different Dose Drug-Coated Balloons: Systematic Review and Meta-Analysis. Vascular. https://doi.org/10.1177/17085381241307765 |
| [57] | Kirtane, A.J., Shlofmitz, R., Moses, J., et al. (2025) Paclitaxel-Coated Balloon for the Treatment of Multilayer In-Stent Restenosis: AGENT IDE Subgroup Analysis. Journal of the American College of Cardiology, 86, 502-511. |
| [58] | Özpak, B. and Çayır, M.Ç. (2020) Drug-Eluting Balloon Treatment in Femoropopliteal In-Stent Restenosis of Different Lengths. Turkish Journal of Thoracic and Cardiovascular Surgery, 28, 460-466. |
| [59] | Anantha-Narayanan, M., Love, K., Nagpal, S., Sheikh, A.B., Regan, C.J. and Mena-Hurtado, C. (2020) Safety and Efficacy of Paclitaxel Drug-Coated Balloon in Femoropopliteal In-Stent Restenosis. Expert Review of Medical Devices, 17, 533-539. https://doi.org/10.1080/17434440.2020.1770593 |
| [60] | Wang, X., Lu, W., Wang, X., Pan, L., Fu, W., Liu, Q., et al. (2020) Drug-Coated Balloon Angioplasty: Predicting Outcomes Based on Different Patterns of Drug-Eluting Stent Restenosis. The International Journal of Cardiovascular Imaging, 36, 171-178. https://doi.org/10.1007/s10554-019-01681-y |
| [61] | Li, L., Tong, Z., Cui, S. and Guo, L. (2023) Debulking Plus Drug-Coated Balloon Angioplasty versus Drug-Coated Balloon Angioplasty Alone for Femoropopliteal Tosaka III In-Stent Restenosis Lesions. Videosurgery and Other Miniinvasive Techniques, 18, 166-172. https://doi.org/10.5114/wiitm.2022.119936 |
| [62] | Suriyanto, M.G.R.I., Pranata, R., Kamarullah, W., Putra, I.C.S., Wahyudi, D.P., Karwiky, G., et al. (2024) The Efficacy and Safety of Atherectomy Combined with Drug-Coated Balloon Angioplasty vs. Drug-Coated Balloon Angioplasty for the Treatment of Lower Extremity Artery Disease: A Systematic Review and Meta-Analysis. Frontiers in Cardiovascular Medicine, 11, Article 1472064. https://doi.org/10.3389/fcvm.2024.1472064 |
| [63] | Xie, H., Qiu, M., Li, X., Xiao, Y., Mu, Y., Wang, G., et al. (2024) Drug-Coated Balloon Angioplasty versus Drug-Eluting Stent Implantation in ACS Patients with Different Angiographic Patterns of In-Stent Restenosis. International Journal of Cardiology, 415, Article 132450. https://doi.org/10.1016/j.ijcard.2024.132450 |
| [64] | Geith, M.A., Eckmann, J.D., Haspinger, D.C., Agrafiotis, E., Maier, D., Szabo, P., et al. (2020) Experimental and Mathematical Characterization of Coronary Polyamide-12 Balloon Catheter Membranes. PLOS ONE, 15, e0234340. https://doi.org/10.1371/journal.pone.0234340 |
| [65] | Somsen, Y.B.O., Rissanen, T.T., Hoek, R., Ris, T.H., Stuijfzand, W.J., Nap, A., et al. (2025) Application of Drug-Coated Balloons in Complex High Risk and Indicated Percutaneous Coronary Interventions. Catheterization and Cardiovascular Interventions, 105, 494-516. https://doi.org/10.1002/ccd.31316 |
| [66] | Tao, Y., Xiao, D., Chen, Y. and Liu, S. (2025) Therapeutic Applications of Drug Coated Balloons in Symptomatic Intracranial Arterial Stenosis: Systematic Review and Quantitative Meta-Analysis. Journal of NeuroInterventional Surgery. https://doi.org/10.1136/jnis-2024-022878 |
| [67] | Nestelberger, T., Kaiser, C. and Jeger, R. (2020) Drug-Coated Balloons in Cardiovascular Disease: Benefits, Challenges, and Clinical Applications. Expert Opinion on Drug Delivery, 17, 201-211. https://doi.org/10.1080/17425247.2020.1714590 |
| [68] | Ge, J.B. and Chen, Y.D. (2024) Chinese Expert Consensus on the Clinical Application of Drug-Coated Balloon (2nd Edition). Journal of Geriatric Cardiology, 21, 135-152. |
| [69] | Fujihara, M., Takahara, M., Soga, Y., Iida, O., Kawasaki, D., Tomoi, Y., et al. (2023) Application of First-Generation High-and Low-Dose Drug-Coated Balloons to the Femoropopliteal Artery Disease: A Sub-Analysis of the POPCORN Registry. CVIR Endovascular, 6, Article No. 41. https://doi.org/10.1186/s42155-023-00390-x |
| [70] | Jiang, X.L., Li, X.Y., Chen, B., et al. (2022) Application Value of Excimer Laser Ablation Combined with Drug-Coated Balloon in Non-Stent Atherosclerotic Lesions of Lower Extremity Arteries. Chinese Journal of Surgery, 60, 1057-1062. |
| [71] | Qiao, G.Y., Jiang, X.L., Chen, B., et al. (2023) Application and Value of Intravascular Ultrasound for Excimer Laser Ablation Combined with Drug-Coated Balloon in the Treatment of Lower Limb Arteriosclerotic Obliterans. Chinese Journal of Surgery, 61, 150-155. |
