Introduction: Tuberculosis (TB) and diabetes mellitus (DM) are two major public health challenges, particularly in developing countries where their prevalence continues to rise. Diabetes is a recognized risk factor for TB, contributing to more severe disease forms and increased complications. This study aimed to assess the prevalence of diabetes among TB patients in Kinshasa and to identify associated factors. Methodology: A cross-sectional analytical study was conducted among 336 TB patients receiving treatment at several health centers in Kinshasa. Sociodemographic, clinical, and paraclinical data were collected and analyzed using statistical tests to identify factors associated with diabetes. Univariate and multivariate logistic regression analyses were performed. Results: Among the 336 TB patients, 38 had diabetes, corresponding to a prevalence of 11.3% [95%CI 8.1 - 15.3]. The study population showed a male predominance (62.5%) with a median age of 34 years. Factors significantly associated with diabetes included age ≥ 34 years (Adjusted Odds Ratio [AOR] = 4.9, p < 0.0001), hypertension (AOR = 2.6, p = 0.048), and the presence of cavitary lung lesions (70.8% in diabetics vs. 29.8% in non-diabetics, p = 0.0129). Conclusion: This study highlights a high prevalence of diabetes mellitus among tuberculosis patients in Kinshasa and demonstrates a significant association between the two conditions. These findings emphasize the need for integrated management strategies, including systematic diabetes screening in TB patients and close metabolic monitoring, to reduce comorbidity and improve treatment outcomes.
References
[1]
World Health Organization (2023) Global Tuberculosis Report. GTB/WHO.
[2]
Coleman, M., Martinez, L., Theron, G., Wood, R. and Marais, B. (2022) Mycobacterium Tuberculosis Transmission in High-Incidence Settings—New Paradigms and Insights. Pathogens, 11, Article 1228. https://doi.org/10.3390/pathogens11111228
[3]
Firănescu, A., Popa, A., Sandu, M., Protasiewicz, D.C., Popa, S.G. and Moţa, M. (2016) The Global Prevalence and Incidence of Diabetes Mellitus and Pulmonary Tuberculosis. RomanianJournalofDiabetesNutritionandMetabolicDiseases, 23, 319-326. https://doi.org/10.1515/rjdnmd-2016-0038
[4]
Kaslam, J., Longo-Mbenza, B., Nge, O., Kangola, K., Mbungu, F. and Milongo, D. (2010) Classification and Dramatic Epidemic of Diabetes Mellitus in Kinshasa Hinterland: The Prominent Role of Type 2 Diabetes and Lifestyle Changes among Africans. NigerianJournalofMedicine, 18, 311-320. https://doi.org/10.4314/njm.v18i3.51202
[5]
Atantama, M., Mafuta Munganga, D., Kapongo Yobo, R., Bidingija Mabika, J., Mikobi Minga, J., Kisoka Lusunsi, C., et al. (2025) Factors Associated with Poor Therapeutic Compliance among Diabetic Patients in Health Facilities of Kinshasa. Diabetes, MetabolicSyndromeandObesity, 18, 1365-1371. https://doi.org/10.2147/dmso.s508883
[6]
Bisuta-Fueza, S., et al. (2018) Tendances de la tuberculose pulmonaire bactériologiquement confirmée et issues thérapeutiques en République Démocratique du Congo: 2007-2017. Annales Africaines de Médecine, 11, 2489-2496.
[7]
Hackman, H.K., Annison, L., Appiah, M., Arhin, R.E., Akorli, W.E.K., Annison, S., et al. (2024) Diabetes and Tuberculosis Comorbidity: A Cross-Sectional Study of Patients Attending Diabetes Clinic in Accra, Ghana. AfricanJournalofClinicalandExperimentalMicrobiology, 25, 421-427. https://doi.org/10.4314/ajcem.v25i4.6
[8]
Li, S., Liang, Y. and Hu, X. (2022) Risk Factors for Multidrug Resistance in Tuberculosis Patients with Diabetes Mellitus. BMCInfectiousDiseases, 22, Article No. 835. https://doi.org/10.1186/s12879-022-07831-3
[9]
Franco, J.V.A., et al. (2024) Diabetes as a Risk Factor for Tuberculosis Disease (Review). Cochrane Database of Systematic Reviews, 8, CD016013.
[10]
Cadena, J., Rathinavelu, S., Lopez-Alvarenga, J.C. and Restrepo, B.I. (2019) The Re-Emerging Association between Tuberculosis and Diabetes: Lessons from Past Centuries. Tuberculosis, 116, S89-S97. https://doi.org/10.1016/j.tube.2019.04.015
[11]
Chiang, C., Lee, J., Chien, S., Enarson, D.A., Chang, Y., Chen, Y., et al. (2014) Glycemic Control and Radiographic Manifestations of Tuberculosis in Diabetic Patients. PLOSONE, 9, e93397. https://doi.org/10.1371/journal.pone.0093397
[12]
Gautam, S., Shrestha, N., Mahato, S., Nguyen, T.P.A., Mishra, S.R. and Berg-Beckhoff, G. (2021) Diabetes among Tuberculosis Patients and Its Impact on Tuberculosis Treatment in South Asia: A Systematic Review and Meta-Analysis. ScientificReports, 11, Article No. 2113. https://doi.org/10.1038/s41598-021-81057-2
[13]
Nkisi, G.B., Yobi, D.M., Zono, B.B., Kabututu, P.Z., Mikobi, T.M. and Bisuta, S.F. (2025) Higher Prevalence of Pulmonary Tuberculosis Revealed by Xpert MTB/RIF Ultra among Drug Users in Kinshasa, Democratic Republic of Congo. BMCInfectiousDiseases, 25, Article No. 464. https://doi.org/10.1186/s12879-025-10853-2
[14]
Eckold, C., et al. (2021) Impact of Intermediate Hyperglycemia and Diabetes on Immune Dysfunction in Tuberculosis. Clinical Infectious Diseases, 72, 69-78.
[15]
Yorke, E., Atiase, Y., Akpalu, J., Sarfo-Kantanka, O., Boima, V. and Dey, I.D. (2017) The Bidirectional Relationship between Tuberculosis and Diabetes. TuberculosisResearchandTreatment, 2017, Article ID: 1702578. https://doi.org/10.1155/2017/1702578
[16]
Programme National de lutte cotre la Tuberculose (2022) PATI-6. PNLT/MSP. https://www.tbdiah.org/resources/publications/guide-de-prise-en-charge-de-la-tuberculose-pati-6/
[17]
Mambandu, G.L., Tepungipame, A.T., Fueza, S.B. and Likwela, J.L. (2025) Clinical, Diagnostic, and Evolutionary Profiles of TB Patients Followed up in Kisangani, Democratic Republic of the Congo: A Short Report. JournalofBiosciencesandMedicines, 13, 131-142. https://doi.org/10.4236/jbm.2025.137010
[18]
Baldé, N.M., et al. (2006) Tuberculose et diabète à Conakry, Guinée: Prévalence et caractéristique cliniques de l’association. The International Journal of Tuberculosis and Lung Disease, 10, 1036-1040.
[19]
Diarra, B., et al. (2014) Tuberculose et diabète à Bamako, Mali: Prévalence et caractéristiques épidémiocliniques de l’association. Revue Malienne d Infectiologie et de Microbiologie Tome, 2, 29-40.
[20]
Foe-Essomba, J.R., et al. (2021) Diabetes Mellitus and Tuberculosis, a Systematic Review and Meta-Analysis with Sensitivity Analysis for Studies Comparable for Con-founders. PLOS One, 16, e0261246.
[21]
Kouismi, H., Hammi, S., Bouti, K., Rhanim, A., El Ataouna, K., Razine, R., et al. (2015) Pulmonary Tuberculosis and Diabetes Mellitus Profile. InternationalJournalofMedicineandSurgery, 2, 11-15. https://doi.org/10.15342/ijms.v2i1.68
[22]
Restrepo, B.I., et al. (2021) Cross-Sectional Assessment Reveals High Diabetes Prevalence among Newly-Diagnosed Tuberculosis Cases. Bulletin of the World Health Organization, 89, 352-359. https://www.scielosp.org/article/bwho/2011.v89n5/352-359/
[23]
Kumar, N.P., Sridhar, R., Nair, D., Banurekha, V.V., Nutman, T.B. and Babu, S. (2015) Type 2 Diabetes Mellitus Is Associated with Altered CD8+ T and Natural Killer Cell Function in Pulmonary Tuberculosis. Immunology, 144, 677-686. https://doi.org/10.1111/imm.12421
[24]
Chiang, C.Y., Bai, K.J., Lin, H.H., Chien, S.T., Lee, J.J., Enarson, D.A., et al. (2015) The Influence of Diabetes, Glycemic Control, and Diabetes-Related Comorbidities on Pulmonary Tuberculosis. PLOSONE, 10, e0121698. https://doi.org/10.1371/journal.pone.0121698
[25]
Leegaard, A., Riis, A., Kornum, J.B., Prahl, J.B., Thomsen, V.Ø., Sørensen, H.T., et al. (2011) Diabetes, Glycemic Control, and Risk of Tuberculosis. DiabetesCare, 34, 2530-2535. https://doi.org/10.2337/dc11-0902
[26]
Noubiap, J.J., et al. (2019) Global Prevalence of Diabetes in Active Tuberculosis: A Systematic Review and Meta-Analysis of Data from 2∙3 Million Patients with Tuberculosis. TheLancetGlobalHealth, 7, e448-e460. https://www.thelancet.com/journals/langlo/article/PIIS2214-109X(18)30487-X/fulltext
[27]
Hadji, W., etal. (2012) Les particularités de la tuberculose pulmonaire chez les diabétiques dans le service d’endocrinologie-diabétologie de l’hôpital militaire, Rabat, Maroc. Elsevier, 139.
[28]
Ottenhoff, T.H.M. (2012) The Knowns and Unknowns of the Immunopathogenesis of Tuberculosis [State of the Art]. TheInternationalJournalofTuberculosisandLungDisease, 16, 1424-1432. https://doi.org/10.5588/ijtld.12.0479
[29]
Boadu, A.A., Yeboah-Manu, M., Osei-Wusu, S. and Yeboah-Manu, D. (2024) Tuberculosis and Diabetes Mellitus: The Complexity of the Comorbid Interactions. InternationalJournalofInfectiousDiseases, 146, Article ID: 107140. https://doi.org/10.1016/j.ijid.2024.107140
[30]
Khalil, N.H. and Ramadan, R.A. (2016) Study of Risk Factors for Pulmonary Tuberculosis among Diabetes Mellitus Patients. EgyptianJournalofChestDiseasesandTuberculosis, 65, 817-823. https://doi.org/10.1016/j.ejcdt.2016.05.009
[31]
Stalenhoef, J.E., et al. (2018) The Role of Interferon-γ in the Increased Tuberculosis Risk in Type 2 Diabetes Mellitus. European Journal of Clinical Microbiology & Infectious Diseases, 27, 97-103.
[32]
Theron, H.D., et al. (1987) Autonomic Neuropathy and Atypical Myocardial Infarction in a Diabetic Clinic Population. South African Medical Journal, 72, 253-254.
[33]
Faerman, I., Faccio, E., Milei, J., Nunez, R., Jadzinsky, M., Fox, D., et al. (1977) Autonomic Neuropathy and Painless Myocardial Infarction in Diabetic Patients. Histologic Evidence of Their Relationship. Diabetes, 26, 1147-1158. https://doi.org/10.2337/diabetes.26.12.1147
[34]
Young, J. (2016) Endocrinologie diabétologie et maladies métaboliques collège des enseignements Endocrinologie diabétologie et maladies métaboliques. 3rd Edition, Elsevier, 437-440.