A 79-year-old male presented to the general medicine department with one-month history of pitting edema of the dorsum of the hands and lower legs. The patient had no recent history of such an episode. On arrival, his vital signs were as follows: Glasgow Coma Scale, E4V5M6; body temperature, 36.6？C; blood pressure, 146/84 mmHg; heart rate, 87 beats/min; respiratory rate, 16 breaths/min; and oxygen saturation, 97% on room air. Laboratory investigations and imaging revealed no remarkable findings. After loxoprofen was prescribed by the orthopedic department for lower back pain, edema developed. Drug-induced edema due to loxoprofen was suspected and, approximately 1 month after discontinuing the drug, the edema fully disappeared. This report aims to raise awareness among physicians, who should consider the possibility of a drug causing symptoms such as edema.
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