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Curative Outcome of Osteosarcoma with Associated Pleural Effusion: A Case Report
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Abstract:
Background: Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Pulmonary metastasis is frequent, but pleural effusion is an unusual and challenging concomitant finding. We present a case of osteosarcoma with pleural effusion, managed successfully with multimodal therapy, and no recurrence after 3 years of follow-up. Case Presentation: We report a 17-year-old boy with osteosarcoma of the distal femur and reactive left-sided pleural effusion. The patient underwent thoracentesis followed by neoadjuvant chemotherapy, limb-salvage surgery, and adjuvant chemotherapy. The effusion resolved and did not recur. Conclusion: This case highlights that pleural effusion may accompany bone tumors even without metastasis, and that multidisciplinary management can achieve excellent outcomes.
| [1] | Marina, N., Gebhardt, M., Teot, L. and Gorlick, R. (2004) Biology and Therapeutic Advances for Pediatric Osteosarcoma. The Oncologist, 9, 422-441. https://doi.org/10.1634/theoncologist.9-4-422 |
| [2] | Martínez Barroso, K., Borregón Rivilla, M., Mazariegos Rubí, M. and Medina Martínez, J. (2021) Severe Lung and Pleural Involvement Due to Osteosarcoma in a 24-Year-Old Woman. Archivos de Bronconeumología, 57, 771. https://doi.org/10.1016/j.arbres.2021.01.034 |
| [3] | American Cancer Society. Osteosarcoma Stages and Prognostic Markers. https://www.cancer.org/cancer/types/osteosarcoma/detection-diagnosis-staging/staging.html |
| [4] | Gaillard, F. (2023) Pleural Metastases. Radiopaedia. https://radiopaedia.org/articles/pleural-metastases |
| [5] | Miravitlles, M., Tonia, T., Rigau, D., Roche, N., Genton, C., Vaccaro, V., et al. (2018) New Era for European Respiratory Society Clinical Practice Guidelines: Joining Efficiency and High Methodological Standards. European Respiratory Journal, 51, Article ID: 1800221. https://doi.org/10.1183/13993003.00221-2018 |
| [6] | Bacci, G., Briccoli, A., Ferrari, S., Longhi, A., Mercuri, M., Capanna, R., et al. (2001) Neoadjuvant Chemotherapy for Osteosarcoma of the Extremity: Long-Term Results of the Rizzoli’s 4th Protocol. European Journal of Cancer, 37, 2030-2039. https://doi.org/10.1016/s0959-8049(01)00229-5 |
| [7] | Harris, M.B., Gieser, P., Goorin, A.M., Ayala, A., Shochat, S.J., Ferguson, W.S., et al. (1998) Treatment of Metastatic Osteosarcoma at Diagnosis: A Pediatric Oncology Group Study. Journal of Clinical Oncology, 16, 3641-3648. https://doi.org/10.1200/jco.1998.16.11.3641 |
| [8] | Bacci, G., Bertoni, F., Longhi, A., Ferrari, S., Forni, C., Biagini, R., et al. (2003) Neoadjuvant Chemotherapy for High-Grade Central Osteosarcoma of the Extremity: Histologic Response to Preoperative Chemotherapy Correlates with Histologic Subtype of the Tumor. Cancer, 97, 3068-3075. https://doi.org/10.1002/cncr.11456 |
