Traumatic events, such as sexual/physical assaults and motor vehicle accidents, frequently involve individuals who are under the influence of alcohol. Research suggests that peri-traumatic alcohol ingestion can increase the risk for PTSD symptomatology, particularly intrusive memories. However, no studies have examined the impact of alcohol on what participants remember about a laboratory-controlled stressful event or the number of intrusive memories that result from such an event. Thus, in the present study, participants ingested ethanol or a placebo and were then exposed to a modified version of the Trier Social Stress Test (TSST) or the friendly-TSST (f-TSST). The TSST required participants to deliver a ten-minute speech in front of two lab panel members as part of a mock job interview; the f-TSST required participants to casually converse with panel members about their interests and hobbies. In both conditions, the panel members interacted with (central) or did not interact with (peripheral) several objects sitting on a desk in front of them. The next day, participants’ memory for the objects that were present on Day 1 was assessed with recall and recognition tests. We also quantified participants’ intrusive memories on Days 2, 4, 6, and 8. Participants exposed to the TSST exhibited greater recall of central and peripheral objects and fewer falsely recalled objects than participants exposed to the f-TSST. Importantly, on Days 2 and 4, participants exposed to the TSST reported a greater number of intrusive memories related to the speech task, and this effect was augmented by alcohol. Our findings suggest that memory for a stressful event is enhanced, relative to memory for a non-stressful event, and that alcohol may increase the development of intrusive memories related to a stressful experience.
References
[1]
Levine, L.J. and Edelstein, R.S. (2009) Emotion and Memory Narrowing: A Review and Goal-Relevance Approach. Cognition and Emotion, 23, 833-875. https://doi.org/10.1080/02699930902738863
[2]
Kensinger, E.A. (2009) Remembering the Details: Effects of Emotion. Emotion Review, 1, 99-113. https://doi.org/10.1177/1754073908100432
[3]
Payne, J.D., Jackson, E.D., Hoscheidt, S., Ryan, L., Jacobs, W.J. and Nadel, L. (2007) Stress Administered Prior to Encoding Impairs Neutral but Enhances Emotional Long-Term Episodic Memories. Learning & Memory, 14, 861-868. https://doi.org/10.1101/lm.743507
[4]
Payne, J., Jackson, E., Ryan, L., Hoscheidt, S., Jacobs, J. and Nadel, L. (2006) The Impact of Stress on Neutral and Emotional Aspects of Episodic Memory. Memory, 14, 1-16. https://doi.org/10.1080/09658210500139176
[5]
Jelici, M., Geraerts, E., Merckelbach, H. and Guerrieri, R. (2004) Acute Stress Enhances Memory for Emotional Words, but Impairs Memory for Neutral Words. International Journal of Neuroscience, 114, 1343-1351. https://doi.org/10.1080/00207450490476101
[6]
Diamond, D.M., Campbell, A.M., Park, C.R., Halonen, J. and Zoladz, P.R. (2007) The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law. Neural Plasticity, 2007, Article ID: 60803. https://doi.org/10.1155/2007/60803
[7]
Arnsten, A.F.T., Raskind, M.A., Taylor, F.B. and Connor, D.F. (2015) The Effects of Stress Exposure on Prefrontal Cortex: Translating Basic Research into Successful Treatments for Post-Traumatic Stress Disorder. Neurobiology of Stress, 1, 89-99. https://doi.org/10.1016/j.ynstr.2014.10.002
[8]
McGaugh, J.L. (2004) The Amygdala Modulates the Consolidation of Memories of Emotionally Arousing Experiences. Annual Review of Neuroscience, 27, 1-28. https://doi.org/10.1146/annurev.neuro.27.070203.144157
[9]
LaBar, K.S. and Cabeza, R. (2006) Cognitive Neuroscience of Emotional Memory. Nature Reviews Neuroscience, 7, 54-64. https://doi.org/10.1038/nrn1825
[10]
van Stegeren, A.H. (2008) The Role of the Noradrenergic System in Emotional Memory. Acta Psychologica, 127, 532-541. https://doi.org/10.1016/j.actpsy.2007.10.004
[11]
Stanek, M.L., Boaz, K.M., Cordes, C.N., Niese, T.D., Long, K.E., Risner, M.S., et al. (2024) Social Evaluative Stress Enhances Central Detail Memory, Reduces False Memory, and Results in Intrusive Memories That Last for Days. Neurobiology of Learning and Memory, 209, Article 107906. https://doi.org/10.1016/j.nlm.2024.107906
[12]
Wiemers, U.S., Sauvage, M.M., Schoofs, D., Hamacher-Dang, T.C. and Wolf, O.T. (2013) What We Remember from a Stressful Episode. Psychoneuroendocrinology, 38, 2268-2277. https://doi.org/10.1016/j.psyneuen.2013.04.015
[13]
Wiemers, U.S., Schoofs, D. and Wolf, O.T. (2012) A Friendly Version of the Trier Social Stress Test Does Not Activate the HPA Axis in Healthy Men and Women. Stress, 16, 254-260. https://doi.org/10.3109/10253890.2012.714427
[14]
Bierbrauer, A., Fellner, M., Heinen, R., Wolf, O.T. and Axmacher, N. (2021) The Memory Trace of a Stressful Episode. Current Biology, 31, 5204-5213.E8. https://doi.org/10.1016/j.cub.2021.09.044
[15]
Herten, N., Otto, T. and Wolf, O.T. (2017) The Role of Eye Fixation in Memory Enhancement under Stress—An Eye Tracking Study. Neurobiology of Learning and Memory, 140, 134-144. https://doi.org/10.1016/j.nlm.2017.02.016
[16]
Herten, N., Pomrehn, D. and Wolf, O.T. (2017) Memory for Objects and Startle Responsivity in the Immediate Aftermath of Exposure to the Trier Social Stress Test. Behavioural Brain Research, 326, 272-280. https://doi.org/10.1016/j.bbr.2017.03.002
[17]
Rüttgens, T. and Wolf, O.T. (2023) Enhanced Memory for Central Visual and Auditory Elements Experienced during a Stressful Episode. Behavioural Brain Research, 452, Article 114546. https://doi.org/10.1016/j.bbr.2023.114546
[18]
Bayless, S.J., Harvey, A.J., Kneller, W. and Frowd, C.D. (2018) Do Intoxicated Witnesses Produce Poor Facial Composite Images? Psychopharmacology, 235, 2991-3003. https://doi.org/10.1007/s00213-018-4989-2
[19]
Avegno, J., Mills, T.J. and Mills, L.D. (2009) Sexual Assault Victims in the Emergency Department: Analysis by Demographic and Event Characteristics. The Journal of Emergency Medicine, 37, 328-334. https://doi.org/10.1016/j.jemermed.2007.10.025
[20]
Brecklin, L.R. and Ullman, S.E. (2010) The Roles of Victim and Offender Substance Use in Sexual Assault Outcomes. Journal of Interpersonal Violence, 25, 1503-1522. https://doi.org/10.1177/0886260509354584
[21]
Mohler-Kuo, M., Dowdall, G.W., Koss, M.P. and Wechsler, H. (2004) Correlates of Rape While Intoxicated in a National Sample of College Women. Journal of Studies on Alcohol, 65, 37-45. https://doi.org/10.15288/jsa.2004.65.37
[22]
Palmer, F.T., Flowe, H.D., Takarangi, M.K.T. and Humphries, J.E. (2013) Intoxicated Witnesses and Suspects: An Archival Analysis of Their Involvement in Criminal Case Processing. Law and Human Behavior, 37, 54-59. https://doi.org/10.1037/lhb0000010
[23]
Testa, M. (2002) The Impact of Men’s Alcohol Consumption on Perpetration of Sexual Aggression. Clinical Psychology Review, 22, 1239-1263. https://doi.org/10.1016/s0272-7358(02)00204-0
[24]
Evans, J.R., Schreiber Compo, N. and Russano, M.B. (2009) Intoxicated Witnesses and Suspects: Procedures and Prevalence According to Law Enforcement. Psychology, Public Policy, and Law, 15, 194-221. https://doi.org/10.1037/a0016837
[25]
Abbey, A., Zawacki, T., Buck, P.O., Clinton, A.M. and McAuslan, P. (2004) Sexual Assault and Alcohol Consumption: What Do We Know about Their Relationship and What Types of Research Are Still Needed? Aggression and Violent Behavior, 9, 271-303. https://doi.org/10.1016/s1359-1789(03)00011-9
[26]
Abbey, A., Zawacki, T., Buck, P.O., Clinton, A.M. and McAuslan, P. (2001) Alcohol and Sexual Assault. Alcohol Res Health, 25, 43-51. https://www.ncbi.nlm.nih.gov/pubmed/11496965
[27]
Steele, C.M. and Josephs, R.A. (1990) Alcohol Myopia: Its Prized and Dangerous Effects. American Psychologist, 45, 921-933. https://doi.org/10.1037//0003-066x.45.8.921
[28]
Bisby, J.A., King, J.A., Brewin, C.R., Burgess, N. and Curran, H.V. (2010) Acute Effects of Alcohol on Intrusive Memory Development and Viewpoint Dependence in Spatial Memory Support a Dual Representation Model. Biological Psychiatry, 68, 280-286. https://doi.org/10.1016/j.biopsych.2010.01.010
[29]
Bisby, J.A., Brewin, C.R., Leitz, J.R. and Valerie Curran, H. (2009) Acute Effects of Alcohol on the Development of Intrusive Memories. Psychopharmacology, 204, 655-666. https://doi.org/10.1007/s00213-009-1496-5
[30]
Jaffe, A.E., Blayney, J.A., Bedard-Gilligan, M. and Kaysen, D. (2019) Are Trauma Memories State-Dependent? Intrusive Memories Following Alcohol-Involved Sexual Assault. European Journal of Psychotraumatology, 10, Article 1634939. https://doi.org/10.1080/20008198.2019.1634939
[31]
Kaysen, D.L., Lindgren, K.P., Lee, C.M., Lewis, M.A., Fossos, N. and Atkins, D.C. (2010) Alcohol‐Involved Assault and the Course of PTSD in Female Crime Victims. Journal of Traumatic Stress, 23, 523-527. https://doi.org/10.1002/jts.20542
[32]
Curran, H.V. and Hildebrandt, M. (1999) Dissociative Effects of Alcohol on Recollective Experience. Consciousness and Cognition, 8, 497-509. https://doi.org/10.1006/ccog.1999.0417
[33]
Leitz, J.R., Morgan, C.J.A., Bisby, J.A., Rendell, P.G. and Curran, H.V. (2009) Global Impairment of Prospective Memory Following Acute Alcohol. Psychopharmacology, 205, 379-387. https://doi.org/10.1007/s00213-009-1546-z
[34]
Söderlund, H., Grady, C.L., Easdon, C. and Tulving, E. (2007) Acute Effects of Alcohol on Neural Correlates of Episodic Memory Encoding. NeuroImage, 35, 928-939. https://doi.org/10.1016/j.neuroimage.2006.12.024
[35]
Duka, T., Weissenborn, R. and Dienes, Z. (2000) State-Dependent Effects of Alcohol on Recollective Experience, Familiarity and Awareness of Memories. Psychopharmacology, 153, 295-306. https://doi.org/10.1007/s002130000564
[36]
Hashtroudi, S., Parker, E.S., DeLisi, L.E., Wyatt, R.J. and Mutter, S.A. (1984) Intact Retention in Acute Alcohol Amnesia. Journal of Experimental Psychology: Learning, Memory, and Cognition, 10, 156-163. https://doi.org/10.1037/0278-7393.10.1.156
[37]
Lister, R.G., Gorenstein, C., Risher-Flowers, D., Weingartner, H.J. and Eckardt, M.J. (1991) Dissociation of the Acute Effects of Alcohol on Implicit and Explicit Memory Processes. Neuropsychologia, 29, 1205-1212. https://doi.org/10.1016/0028-3932(91)90034-6
[38]
White, A.M., Matthews, D.B. and Best, P.J. (2000) Ethanol, Memory, and Hippocampal Function: A Review of Recent Findings. Hippocampus, 10, 88-93. https://doi.org/10.1002/(sici)1098-1063(2000)10:1<88::aid-hipo10>3.0.co;2-l
[39]
Melia, K.R., Ryabinin, A.E., Corodimas, K.P., Wilson, M.C. and LeDoux, J.E. (1996) Hippocampal-dependent Learning and Experience-Dependent Activation of the Hippocampus Are Preferentially Disrupted by Ethanol. Neuroscience, 74, 313-322. https://doi.org/10.1016/0306-4522(96)00138-8
[40]
Matthews, D.B., Morrow, A.L., Tokunaga, S. and McDaniel, J.R. (2002) Acute Ethanol Administration and Acute Allopregnanolone Administration Impair Spatial Memory in the Morris Water Task. Alcoholism: Clinical and Experimental Research, 26, 1747-1751. https://doi.org/10.1111/j.1530-0277.2002.tb02479.x
[41]
Gould, T.J. and Lommock, J.A. (2003) Nicotine Enhances Contextual Fear Conditioning and Ameliorates Ethanol-Induced Deficits in Contextual Fear Conditioning. Behavioral Neuroscience, 117, 1276-1282. https://doi.org/10.1037/0735-7044.117.6.1276
[42]
Meyer, T., Smeets, T., Giesbrecht, T., Quaedflieg, C.W.E.M., Girardelli, M.M., Mackay, G.R.N., et al. (2012) Individual Differences in Spatial Configuration Learning Predict the Occurrence of Intrusive Memories. Cognitive, Affective, & Behavioral Neuroscience, 13, 186-196. https://doi.org/10.3758/s13415-012-0123-9
[43]
Postel, C., Mary, A., Dayan, J., Fraisse, F., Vallée, T., Guillery-Girard, B., et al. (2021) Variations in Response to Trauma and Hippocampal Subfield Changes. Neurobiology of Stress, 15, Article 100346. https://doi.org/10.1016/j.ynstr.2021.100346
[44]
Sierk, A., Manthey, A., King, J., Brewin, C.R., Bisby, J.A., Walter, H., et al. (2019) Allocentric Spatial Memory Performance Predicts Intrusive Memory Severity in Posttraumatic Stress Disorder. Neurobiology of Learning and Memory, 166, Article 107093. https://doi.org/10.1016/j.nlm.2019.107093
[45]
Gilbertson, M.W., Williston, S.K., Paulus, L.A., Lasko, N.B., Gurvits, T.V., Shenton, M.E., et al. (2007) Configural Cue Performance in Identical Twins Discordant for Posttraumatic Stress Disorder: Theoretical Implications for the Role of Hippocampal Function. Biological Psychiatry, 62, 513-520. https://doi.org/10.1016/j.biopsych.2006.12.023
[46]
Gilbertson, M.W., Shenton, M.E., Ciszewski, A., Kasai, K., Lasko, N.B., Orr, S.P., et al. (2002) Smaller Hippocampal Volume Predicts Pathologic Vulnerability to Psychological Trauma. Nature Neuroscience, 5, 1242-1247. https://doi.org/10.1038/nn958
[47]
Lambert, H.K. and McLaughlin, K.A. (2019) Impaired Hippocampus-Dependent Associative Learning as a Mechanism Underlying PTSD: A Meta-Analysis. Neuroscience & Biobehavioral Reviews, 107, 729-749. https://doi.org/10.1016/j.neubiorev.2019.09.024
[48]
Wiemers, U.S. and Wolf, O.T. (2014) Cortisol Broadens Memory of a Non-Stressful Social Interaction. Psychopharmacology, 232, 1727-1733. https://doi.org/10.1007/s00213-014-3808-7
[49]
Wolf, O.T. (2019) Memories of and Influenced by the Trier Social Stress Test. Psychoneuroendocrinology, 105, 98-104. https://doi.org/10.1016/j.psyneuen.2018.10.031
[50]
Badawi, A., Berle, D., Rogers, K. and Steel, Z. (2020) Do Cognitive Tasks Reduce Intrusive-Memory Frequency after Exposure to Analogue Trauma? An Experimental Replication. Clinical Psychological Science, 8, 569-583. https://doi.org/10.1177/2167702620906148
[51]
Keyan, D. and Bryant, R.A. (2017) Brief Exercise Enhances Intrusive Memories of Traumatic Stimuli. Neurobiology of Learning and Memory, 141, 9-13. https://doi.org/10.1016/j.nlm.2017.03.012
[52]
Lau-Zhu, A., Henson, R.N. and Holmes, E.A. (2019) Intrusive Memories and Voluntary Memory of a Trauma Film: Differential Effects of a Cognitive Interference Task after Encoding. Journal of Experimental Psychology: General, 148, 2154-2180. https://doi.org/10.1037/xge0000598
[53]
Schultebraucks, K., Rombold-Bruehl, F., Wingenfeld, K., Hellmann-Regen, J., Otte, C. and Roepke, S. (2019) Heightened Biological Stress Response during Exposure to a Trauma Film Predicts an Increase in Intrusive Memories. Journal of Abnormal Psychology, 128, 645-657. https://doi.org/10.1037/abn0000440
[54]
Horowitz, M., Wilner, N. and Alvarez, W. (1979) Impact of Event Scale: A Measure of Subjective Stress. Psychosomatic Medicine, 41, 209-218. https://doi.org/10.1097/00006842-197905000-00004 https://www.ncbi.nlm.nih.gov/pubmed/472086
[55]
Spielberger, C.D., Gorsuch, R.L., Lushene, R.D., Vagg, P.R. and Jacobs, G.A. (1983) Manual for the State-Trait Anxiety Inventory. Consulting Psychologist Press.
[56]
Corwin, J. (1994) On Measuring Discrimination and Response Bias: Unequal Numbers of Targets and Distractors and Two Classes of Distractors. Neuropsychology, 8, 110-117. https://doi.org/10.1037/0894-4105.8.1.110
[57]
Snodgrass, J.G. and Corwin, J. (1988) Pragmatics of Measuring Recognition Memory: Applications to Dementia and Amnesia. Journal of Experimental Psychology: General, 117, 34-50. https://doi.org/10.1037//0096-3445.117.1.34
[58]
Bowers, A.J. and Zhou, X. (2019) Receiver Operating Characteristic (ROC) Area under the Curve (AUC): A Diagnostic Measure for Evaluating the Accuracy of Predictors of Education Outcomes. Journal of Education for Students Placed at Risk (JESPAR), 24, 20-46. https://doi.org/10.1080/10824669.2018.1523734
[59]
Weidemann, C.T. and Kahana, M.J. (2016) Assessing Recognition Memory Using Confidence Ratings and Response Times. Royal Society Open Science, 3, Article 150670. https://doi.org/10.1098/rsos.150670
[60]
Liberzon, I. and Abelson, J.L. (2016) Context Processing and the Neurobiology of Post-Traumatic Stress Disorder. Neuron, 92, 14-30. https://doi.org/10.1016/j.neuron.2016.09.039
[61]
Bisby, J.A., Burgess, N. and Brewin, C.R. (2020) Reduced Memory Coherence for Negative Events and Its Relationship to Posttraumatic Stress Disorder. Current Directions in Psychological Science, 29, 267-272. https://doi.org/10.1177/0963721420917691
[62]
Merz, C.J. and Wolf, O.T. (2016) Stress and Emotional Learning in Humans: Evidence for Sex Differences. In: Shansky, R.M., Ed., Sex Differences in the Central Nervous System, Academic Press, 149-170. https://doi.org/10.1016/b978-0-12-802114-9.00007-x
[63]
Niaura, R.S., Nathan, P.E., Frankenstein, W., Shapiro, A.P. and Brick, J. (1987) Gender Differences in Acute Psychomotor, Cognitive, and Pharmacokinetic Response to Alcohol. Addictive Behaviors, 12, 345-356. https://doi.org/10.1016/0306-4603(87)90048-7
