The authors have previously reported on the deleterious effects of sunlight on human skin tissue. Despite ongoing evidence that actinic damage and skin ageing are caused not only by ultraviolet radiation, but also visible light and near-infrared energy, few studies have focused on the additive impact of the sun’s total energy. In the past, ultraviolet radiation was assumed to be the only biologically significant factor in skin actinic damage, but in recent decades this view has been considerably revised to include the impact of the sun’s complete energy reaching the earth affecting terrestrial life, including humans. In this paper, we summarize the evidence supporting actinic damage and the cumulative negative effects of ultraviolet, visible light and near-infrared radiation as the major cause of photoaging, pigmentation, vascular irregularity, muscle thinning, skin ptosis, photoimmunosuppression and photocarcinogenesis. Visible skin aging associated with actinic damage is differentiated from chronologic aging, which is less defined by the stigmata of photoaging associated with changes to skin tone, texture and laxity. Awareness of the biological effects of total solar energy output and understanding actinic damage may assist physicians and patients to seek comprehensive solar protection and repair strategies including sun avoidance and topical preparations that protect from ultraviolet, visible light and near-infrared as well as skin repair mechanisms including retinoids and DNA repair enzymes.
References
[1]
Bilaç, C., Şahin, M.T. and Öztürkcan, S. (2014) Chronic Actinic Damage of Facial Skin. ClinicsinDermatology, 32, 752-762. https://doi.org/10.1016/j.clindermatol.2014.02.014
[2]
Green, H.A. and Drake, L. (1993) Aging, Sun Damage, and Sunscreens. ClinicsinPlasticSurgery, 20, 1-8. https://doi.org/10.1016/s0094-1298(20)30767-7
[3]
Farage, M.A., Miller, K.W., Elsner, P. and Maibach, H.I. (2008) Intrinsic and Extrinsic Factors in Skin Ageing: A Review. InternationalJournalofCosmeticScience, 30, 87-95. https://doi.org/10.1111/j.1468-2494.2007.00415.x
Hussein, R.S., Bin Dayel, S., Abahussein, O. and El-Sherbiny, A.A. (2024) Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. JournalofCosmeticDermatology, 24, e16688. https://doi.org/10.1111/jocd.16688
[6]
Liebel, F., Kaur, S., Ruvolo, E., Kollias, N. and Southall, M.D. (2012) Irradiation of Skin with Visible Light Induces Reactive Oxygen Species and Matrix-Degrading Enzymes. JournalofInvestigativeDermatology, 132, 1901-1907. https://doi.org/10.1038/jid.2011.476
[7]
Lisa Gale, Y.T. (2013) The Necessity of Near-Infrared Protection. Surgery: CurrentResearch, 3, Article ID: 1000150. https://doi.org/10.4172/2161-1076.1000150
[8]
Tanaka, Y. and Gale, L. (2013) Beneficial Applications and Deleterious Effects of Near-Infrared from Biological and Medical Perspectives. OpticsandPhotonicsJournal, 3, 31-39. https://doi.org/10.4236/opj.2013.34a006
[9]
Tanaka, Y. and Gale, L. (2015) Protection from Near-Infrared to Prevent Skin Damage. OpticsandPhotonicsJournal, 5, 113-118. https://doi.org/10.4236/opj.2015.54010
[10]
Tanaka, Y. (2017) The Necessity of Solar Near-infrared Protection Shown through Gene Expression Changes. Australasian Journal of Dermatology, 58, 91.
[11]
Calderhead, R.G. and Tanaka, Y. (2017) Photobiological Basics and Clinical Indications of Phototherapy for Skin Rejuvenation. In: Tanaka, Y., Ed., Photomedicine—AdvancesinClinicalPractice, InTech, 215-252. https://doi.org/10.5772/intechopen.68723
[12]
Guan, L.L., Lim, H.W. and Mohammad, T.F. (2021) Sunscreens and Photoaging: A Review of Current Literature. AmericanJournalofClinicalDermatology, 22, 819-828. https://doi.org/10.1007/s40257-021-00632-5
[13]
Lim, H.W., Kohli, I., Ruvolo, E., Kolbe, L. and Hamzavi, I.H. (2022) Impact of Visible Light on Skin Health: The Role of Antioxidants and Free Radical Quenchers in Skin Protection. JournaloftheAmericanAcademyofDermatology, 86, S27-S37. https://doi.org/10.1016/j.jaad.2021.12.024
[14]
Mineroff, J., Nguyen, J.K. and Jagdeo, J. (2023) The Importance of Photoaging Prevention in All Skin Types: An Update on Current Advancements. JournalofDrugsinDermatology, 23, 1306-1310. https://doi.org/10.36849/jdd.7255
[15]
Tanaka, Y. (2023) Photoprotective Ability of Sunscreens against Ultraviolet, Visible Light and Near-Infrared Radiation. OpticsandPhotonicsJournal, 13, 140-146. https://doi.org/10.4236/opj.2023.136012
[16]
Tanaka, Y., Parker, R. and Aganahi, A. (2023) Photoprotective Ability of Colored Iron Oxides in Tinted Sunscreens against Ultraviolet, Visible Light and Near-Infrared Radiation. OpticsandPhotonicsJournal, 13, 199-208. https://doi.org/10.4236/opj.2023.138018
[17]
Flament, F., Bazin, R., Rubert, V., Simonpietri, E., Piot, B. and Laquieze,S. (2013) Effect of the Sun on Visible Clinical Signs of Aging in Caucasian Skin. Clinical, CosmeticandInvestigationalDermatology, 6, 221-232. https://doi.org/10.2147/ccid.s44686
[18]
Tanaka, Y., Matsuo, K. and Yuzuriha, S. (2010) Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized with Wavelength and Contact Cooling: A Preliminary Report. ePlasty, 10, e40. https://www.hmpgloballearningnetwork.com/site/eplasty/long-lasting-muscle-thinning-induced-infrared-irradiation-specialized-wavelengths-and
[19]
Tanaka, Y., Matsuo, K. and Yuzuriha, S. (2011) Near-Infrared Irradiation Non-Thermally Induces Long-Lasting Vasodilation by Causing Apoptosis of Vascular Smooth Muscle Cells. ePlasty, 11, e22. https://www.hmpgloballearningnetwork.com/site/eplasty/near-infrared-irradiation-nonthermally-induces-long-lasting-vasodilation-causing
[20]
Tanaka, Y. and Matsuo, K. (2011) Non-Thermal Effects of Near-Infrared Irradiation on Melanoma. In: Tanaka, Y., Ed., BreakthroughsinMelanomaResearch, InTech, 597-628. https://doi.org/10.5772/38663
[21]
Tanaka, Y. (2012) Impact of Near-Infrared Radiation in Dermatology. WorldJournalofDermatology, 1, 30-37. https://doi.org/10.5314/wjd.v1.i3.30
[22]
Tanaka, Y. and Nakayama, J. (2016) Upregulated Epidermal Growth Factor Receptor Expression Following Near-Infrared Irradiation Simulating Solar Radiation in a Three-Dimensional Reconstructed Human Corneal Epithelial Tissue Culture Model. ClinicalInterventionsinAging, 11, 1027-1033. https://doi.org/10.2147/cia.s111530
[23]
Kochevar, I.E., Pathak, M.A. and Parrish, J.A. (1999) Photophysics, Photochemistry and Photobiology. In: Freedberg, I.M., Eisen, A.Z., Wolff, K., etal., Eds., Fitzpatrick’s Dermatology in General Medicine, McGraw-Hill, 220-229.
[24]
Jeffery, G., Fosbury, R., Barrett, E., Hogg, C., Carmona, M.R. and Powner, M.B. (2013) Longer Wavelengths in Sunlight Pass through the Human Body and Have a Systemic Impact Which Improves Vision. Scientific Reports, 15, Article No. 24435.
[25]
Natarajan, V.T., Ganju, P., Ramkumar, A., Grover, R. and Gokhale, R.S. (2014) Multifaceted Pathways Protect Human Skin from UV Radiation. NatureChemicalBiology, 10, 542-551. https://doi.org/10.1038/nchembio.1548
Rittie, L. and Fisher, G.J. (2015) Natural and Sun-Induced Aging of Human Skin. ColdSpringHarborPerspectivesinMedicine, 5, a015370. https://doi.org/10.1101/cshperspect.a015370
[28]
Zargaran, D., Zoller, F., Zargaran, A., Weyrich, T. and Mosahebi, A. (2022) Facial Skin Ageing: Key Concepts and Overview of Processes. InternationalJournalofCosmeticScience, 44, 414-420. https://doi.org/10.1111/ics.12779
[29]
Mohania, D., Chandel, S., Kumar, P., Verma, V., Digvijay, K., Tripathi, D., etal. (2017) Ultraviolet Radiations: Skin Defense-Damage Mechanism. In: Ahmad, S., Ed., Ultraviolet Light in Human Health, Diseases and Environment, Springer, 71-87. https://doi.org/10.1007/978-3-319-56017-5_7
[30]
Juzeniene, A. and Moan, J. (2012) Beneficial Effects of UV Radiation Other than via Vitamin D Production. Dermato-Endocrinology, 4, 109-117. https://doi.org/10.4161/derm.20013
[31]
Agar, N. and Young, A.R. (2005) Melanogenesis: A Photoprotective Response to DNA Damage? MutationResearch/FundamentalandMolecularMechanismsofMutagenesis, 571, 121-132. https://doi.org/10.1016/j.mrfmmm.2004.11.016
[32]
Paunel, A.N., Dejam, A., Thelen, S., Kirsch, M., Horstjann, M., Gharini, P., etal. (2005) Enzyme-Independent Nitric Oxide Formation during UVA Challenge of Human Skin: Characterization, Molecular Sources, and Mechanisms. FreeRadicalBiologyandMedicine, 38, 606-615. https://doi.org/10.1016/j.freeradbiomed.2004.11.018
[33]
Suschek, C.V., Opländer, C. and van Faassen, E.E. (2010) Non-Enzymatic NO Production in Human Skin: Effect of UVA on Cutaneous NO Stores. NitricOxide, 22, 120-135. https://doi.org/10.1016/j.niox.2009.10.006
[34]
Levins, P., Carr, D., Fisher, J., Momtaz, K. and Parrish, J. (1983) Plasma β-Endorphin and β-Lipotropin Response to Ultraviolet Radiation. TheLancet, 322, 166. https://doi.org/10.1016/s0140-6736(83)90150-2
[35]
Sivamani, R.K., Crane, L.A. and Dellavalle, R.P. (2009) The Benefits and Risks of Ultraviolet Tanning and Its Alternatives: The Role of Prudent Sun Exposure. DermatologicClinics, 27, 149-154. https://doi.org/10.1016/j.det.2008.11.008
[36]
Skobowiat, C., Dowdy, J.C., Sayre, R.M., Tuckey, R.C. and Slominski, A. (2011) Cutaneous Hypothalamic-Pituitary-Adrenal Axis Homolog: Regulation by Ultraviolet Radiation. AmericanJournalofPhysiology-EndocrinologyandMetabolism, 301, E484-E493. https://doi.org/10.1152/ajpendo.00217.2011
[37]
Sanches Silveira, J.E.P. and Myaki Pedroso, D.M. (2014) UV Light and Skin Aging. ReviewsonEnvironmentalHealth, 29, 243-254. https://doi.org/10.1515/reveh-2014-0058
[38]
Bosch, R., Philips, N., Suárez-Pérez, J., Juarranz, A., Devmurari, A., Chalensouk-Khaosaat, J., etal. (2015) Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals. Antioxidants, 4, 248-268. https://doi.org/10.3390/antiox4020248
[39]
Gromkowska-Kępka, K.J., Puścion-Jakubik, A., Markiewicz-Żukowska, R. and Socha, K. (2021) The Impact of Ultraviolet Radiation on Skin Photoaging—Review of inVitro Studies. JournalofCosmeticDermatology, 20, 3427-3431. https://doi.org/10.1111/jocd.14033
[40]
Hajialiasgary Najafabadi, A., Soheilifar, M.H. and Masoudi-Khoram, N. (2024) Exosomes in Skin Photoaging: Biological Functions and Therapeutic Opportunity. CellCommunicationandSignaling, 22, Article No. 32. https://doi.org/10.1186/s12964-023-01451-3
[41]
Debacq-Chainiaux, F., Leduc, C., Verbeke, A. and Toussaint, O. (2012) UV, Stress and Aging. Dermato-Endocrinology, 4, 236-240. https://doi.org/10.4161/derm.23652
[42]
Douki, T., von Koschembahr, A. and Cadet, J. (2017) Insight in DNA Repair of UV-Induced Pyrimidine Dimers by Chromatographic Methods. PhotochemistryandPhotobiology, 93, 207-215. https://doi.org/10.1111/php.12685
[43]
Birben, E., Sahiner, U.M., Sackesen, C., Erzurum, S. and Kalayci, O. (2012) Oxidative Stress and Antioxidant Defense. WorldAllergyOrganizationJournal, 5, 9-19. https://doi.org/10.1097/wox.0b013e3182439613
[44]
Young, A.R., Claveau, J. and Rossi, A.B. (2017) Ultraviolet Radiation and the Skin: Photobiology and Sunscreen Photoprotection. JournaloftheAmericanAcademyofDermatology, 76, S100-S109. https://doi.org/10.1016/j.jaad.2016.09.038
[45]
Furukawa, J.Y., Martinez, R.M., Morocho-Jácome, A.L., Castillo-Gómez, T.S., Pereda-Contreras, V.J., Rosado, C., etal. (2021) Skin Impacts from Exposure to Ultraviolet, Visible, Infrared, and Artificial Lights—A Review. JournalofCosmeticandLaserTherapy, 23, 1-7. https://doi.org/10.1080/14764172.2021.1950767
[46]
Fisher, G.J., Wang, Z., Datta, S.C., Varani, J., Kang, S. and Voorhees, J.J. (1997) Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light. NewEnglandJournalofMedicine, 337, 1419-1429. https://doi.org/10.1056/nejm199711133372003
[47]
Austin, E., Geisler, A.N., Nguyen, J., Kohli, I., Hamzavi, I., Lim, H.W., etal. (2021) Visible Light. Part I: Properties and Cutaneous Effects of Visible Light. JournaloftheAmericanAcademyofDermatology, 84, 1219-1231. https://doi.org/10.1016/j.jaad.2021.02.048
[48]
Ezekwe, N., Maghfour, J. and Kohli, I. (2022) Visible Light and the Skin. PhotochemistryandPhotobiology, 98, 1264-1269. https://doi.org/10.1111/php.13634
[49]
Narla, S., Kohli, I., Hamzavi, I.H. and Lim, H.W. (2020) Visible Light in Photodermatology. Photochemical&PhotobiologicalSciences, 19, 99-104. https://doi.org/10.1039/c9pp00425d
[50]
Pourang, A., Tisack, A., Ezekwe, N., Torres, A.E., Kohli, I., Hamzavi, I.H., etal. (2021) Effects of Visible Light on Mechanisms of Skin Photoaging. Photodermatology, Photoimmunology&Photomedicine, 38, 191-196. https://doi.org/10.1111/phpp.12736
[51]
Mahmoud, B.H., Hexsel, C.L., Hamzavi, I.H. and Lim, H.W. (2008) Effects of Visible Light on the Skin. PhotochemistryandPhotobiology, 84, 450-462. https://doi.org/10.1111/j.1751-1097.2007.00286.x
[52]
Lawrence, K.P., Douki, T., Sarkany, R.P.E., Acker, S., Herzog, B. and Young, A.R. (2018) The UV/Visible Radiation Boundary Region (385-405 nm) Damages Skin Cells and Induces “Dark” Cyclobutane Pyrimidine Dimers in Human Skin inVivo. ScientificReports, 8, Article No. 12722. https://doi.org/10.1038/s41598-018-30738-6
[53]
Kohli, I., Nahhas, A.F., Braunberger, T.L., Chaowattanapanit, S., Mohammad, T.F., Nicholson, C.L., etal. (2019) Spectral Characteristics of Visible Light-Induced Pigmentation and Visible Light Protection Factor. Photodermatology, Photoimmunology&Photomedicine, 35, 393-399. https://doi.org/10.1111/phpp.12490
[54]
Sklar, L.R., Almutawa, F., Lim, H.W. and Hamzavi, I. (2012) Effects of Ultraviolet Radiation, Visible Light, and Infrared Radiation on Erythema and Pigmentation: A Review. Photochemical&PhotobiologicalSciences, 12, 54-64. https://doi.org/10.1039/c2pp25152c
[55]
Ruvolo, E., Boothby‐Shoemaker, W., Kumar, N., Hamzavi, I.H., Lim, H.W. and Kohli, I. (2022) Evaluation of Efficacy of Antioxidant‐enriched Sunscreen Products against Long Wavelength Ultraviolet A1 and Visible Light. InternationalJournalofCosmeticScience, 44, 394-402. https://doi.org/10.1111/ics.12785
[56]
Lyons, A.B., Trullas, C., Kohli, I., Hamzavi, I.H. and Lim, H.W. (2021) Photoprotection Beyond Ultraviolet Radiation: A Review of Tinted Sunscreens. JournaloftheAmericanAcademyofDermatology, 84, 1393-1397. https://doi.org/10.1016/j.jaad.2020.04.079
[57]
Geisler, A.N., Austin, E., Nguyen, J., Hamzavi, I., Jagdeo, J. and Lim, H.W. (2021) Visible Light. Part II: Photoprotection against Visible and Ultraviolet Light. JournaloftheAmericanAcademyofDermatology, 84, 1233-1244. https://doi.org/10.1016/j.jaad.2020.11.074
[58]
Tanaka, Y. (2019) Long-term Objective Assessments of Skin Rejuvenation Using Solar Protection and Solar Repair Shown through Digital Facial Surface Analysis and Three-Dimensional Volumetric Assessment. Clinical, CosmeticandInvestigationalDermatology, 12, 553-561. https://doi.org/10.2147/ccid.s218176
[59]
Tanaka, Y. (2020) Three-Dimensional Quantification of Skin Surface Displacement Following Skin Rejuvenation Using Solar Protection and Solar Repair. The Journal of Clinical and Aesthetic Dermatolog, 13, 47-50.
[60]
Tanaka, Y., Parker, R. and Aganahi, A. (2023) Up-Regulated Expression of ICAM1, MT1A, PTGS2, LCE3D, PPARD, and GM-CSF2 Following Solar Skincare Protection and Repair Strategies in a 3-Dimensional Reconstructed Human Skin Model. Clinical, CosmeticandInvestigationalDermatology, 16, 2829-2839. https://doi.org/10.2147/ccid.s428170
[61]
Tanaka, Y., Parker, R., Aganahi, A. and Pedroso, A. (2023) Novel Low Viscosity Zinc Oxide, Iron Oxides and Erioglaucine Sunscreen Potential to Protect from Ultraviolet, Visible Light and Near-Infrared Radiation. OpticsandPhotonicsJournal, 13, 217-226. https://doi.org/10.4236/opj.2023.139020
[62]
Tanaka, Y., Parker, R. and Aganahi, A. (2023) Up-Regulated Expression of SOD2 and HPRT1 Following Topical Photoprotection and Photorepair Skincare Formulations in a 3-Dimensional Reconstructed Human Skin Model. JournalofCosmetics, DermatologicalSciencesandApplications, 13, 322-332. https://doi.org/10.4236/jcdsa.2023.134025
[63]
Zhou, C., Lee, C., Salas, J. and Luke, J. (2023) Guide to Tinted Sunscreens in Skin of Color. InternationalJournalofDermatology, 63, 272-276. https://doi.org/10.1111/ijd.16954
[64]
He, M., Chen, X., Jin, S. and Zhang, C. (2025) Visible Light Protection: An Updated Review of Tinted Sunscreens. Photodermatology, Photoimmunology&Photomedicine, 41, e70033. https://doi.org/10.1111/phpp.70033
[65]
Marsh, K., Aganahi, A., Parker, R. and Tanaka, Y. (2024) Gene Expression Changes Following Solar Skincare Protection and Repair Strategies in a 3-Dimensional Re-constructed Human Skin Model. Journal of Clinical & Experimental Dermatology Research, 15, Article ID: 1000656.
[66]
Tanaka, Y. Parker, R. and Aganahi, A. (2024) Gene Expression Change Analysis Following Specific Comprehensive Solar Protection SPF50+ after Ultraviolet Light and Blue Light Exposure in a 3-Dimensional Reconstructed Human Skin Model. Journal of Dermatology and Plastic Surgery, 5, 1026.
[67]
Aganahi, A., Parker, R. and Tanaka, Y. (2024) InVivo Improvements in Facial Appearance and inVitro Changes in Gene Expression Using a Topical Formulation Designed to Repair Environmentally Induced DNA Damage. JournalofCosmetics, DermatologicalSciencesandApplications, 14, 141-173. https://doi.org/10.4236/jcdsa.2024.142010
[68]
Aganahi, A., Parker, R. and Tanaka, Y. (2025) Skin Hydration Augmentation Following Solar Protective and Repair Skincare Regimen. JournalofCosmetics, DermatologicalSciencesandApplications, 15, 1-23. https://doi.org/10.4236/jcdsa.2025.151001
Anderson, R.R. and Parrish, J.A. (1981) The Optics of Human Skin. JournalofInvestigativeDermatology, 77, 13-19. https://doi.org/10.1111/1523-1747.ep12479191
[71]
Gates, D.M. (1966) Spectral Distribution of Solar Radiation at the Earth’s Surface. Science, 151, 523-529. https://doi.org/10.1126/science.151.3710.523
[72]
Schieke, S.M., Schroeder, P. and Krutmann, J. (2003) Cutaneous Effects of Infrared Radiation: From Clinical Observations to Molecular Response Mechanisms. Photodermatology, Photoimmunology&Photomedicine, 19, 228-234. https://doi.org/10.1034/j.1600-0781.2003.00054.x
[73]
Schroeder, P., Lademann, J., Darvin, M.E., Stege, H., Marks, C., Bruhnke, S., etal. (2008) Infrared Radiation-Induced Matrix Metalloproteinase in Human Skin: Implications for Protection. JournalofInvestigativeDermatology, 128, 2491-2497. https://doi.org/10.1038/jid.2008.116
[74]
Kligman, L.H. (1982) Intensification of Ultraviolet-Induced Dermal Damage by Infrared Radiation. ArchivesofDermatologicalResearch, 272, 229-238. https://doi.org/10.1007/bf00509050
[75]
Tanaka, Y. (2017) Photomedicine: Advances in Clinical Practice. https://www.intechopen.com/books/photomedicine-advances-in-clinical-practice
[76]
Danno, K., Mori, N., Toda, K., Kobayashi, T. and Utani, A. (2001) Near-Infrared Irradiation Stimulates Cutaneous Wound Repair: Laboratory Experiments on Possible Mechanisms. Photodermatology, Photoimmunology&Photomedicine, 17, 261-265. https://doi.org/10.1111/j.1600-0781.2001.170603.x
[77]
Frank, S., Oliver, L., Lebreton-De Coster, C., Moreau, C., Lecabellec, M., Michel, L., etal. (2004) Infrared Radiation Affects the Mitochondrial Pathway of Apoptosis in Human Fibroblasts. JournalofInvestigativeDermatology, 123, 823-831. https://doi.org/10.1111/j.0022-202x.2004.23472.x
[78]
Kim, H.H., Lee, M.J., Lee, S.R., Kim, K.H., Cho, K.H., Eun, H.C., etal. (2005) Augmentation of UV-Induced Skin Wrinkling by Infrared Irradiation in Hairless Mice. MechanismsofAgeingandDevelopment, 126, 1170-1177. https://doi.org/10.1016/j.mad.2005.06.003
[79]
D. K. Kelleher, O. Thews, J. Rzezni, (1999) Hot Topic Water-Filtered Infrared-A Radiation: A Novel Technique for Localized Hyperthermia in Combination with Bacteriochlorophyll-Based Photodynamic Therapy. InternationalJournalofHyperthermia, 15, 467-474. https://doi.org/10.1080/026567399285468
[80]
Davenport, S.A., Gollnick, D.A., Levernier, M. and Spooner, G.J. (2006) Method and System for Treatment of Post-Partum Abdominal Skin Redundancy or Laxity. US Patent 2006/0052847 A.
[81]
Tanaka, Y. and Gale, L. (2013) The Effect of Near-Infrared between 1100-1800 nm Together with a Water-Filter and a Contact Cooling. Anaplastology, 2, 3.
[82]
Tanaka, Y., Tsunemi, Y., Kawashima, M. and Nishida, H. (2013) The Impact of Near-Infrared in Plastic Surgery. PlasticSurgery: AnInternationalJournal, 2013, Article ID: 973073. https://doi.org/10.5171/2013.973073
[83]
Tanaka, Y., Tsunemi, Y., Kawashima, M., Tatewaki, N. and Nishida, H. (2013) Objective Assessment of Skin Tightening in Asians Using a Water-Filtered Near-Infrared (1,000-1,800 nm) Device with Contact-Cooling and Freezer-Stored Gel. Clinical, CosmeticandInvestigationalDermatology, 6, 167-176. https://doi.org/10.2147/ccid.s47299
[84]
Schroeder, P., Haendeler, J. and Krutmann, J. (2008) The Role of Near Infrared Radiation in Photoaging of the Skin. ExperimentalGerontology, 43, 629-632. https://doi.org/10.1016/j.exger.2008.04.010
[85]
Cho, S., Lee, M.J., Kim, M.S., Lee, S., Kim, Y.K., Lee, D.H., etal. (2008) Infrared Plus Visible Light and Heat from Natural Sunlight Participate in the Expression of MMPs and Type I Procollagen as Well as Infiltration of Inflammatory Cell in Human Skin inVivo. JournalofDermatologicalScience, 50, 123-133. https://doi.org/10.1016/j.jdermsci.2007.11.009
[86]
Barolet, D., Christiaens, F. and Hamblin, M.R. (2016) Infrared and Skin: Friend or Foe. JournalofPhotochemistryandPhotobiologyB: Biology, 155, 78-85. https://doi.org/10.1016/j.jphotobiol.2015.12.014
[87]
Horton, L., Brady, J., Kincaid, C.M., Torres, A.E. and Lim, H.W. (2023) The Effects of Infrared Radiation on the Human Skin. Photodermatology, Photoimmunology&Photomedicine, 39, 549-555. https://doi.org/10.1111/phpp.12899
[88]
Horwitz, L.R., Burke, T.J. and Carnegie, D. (1999) Augmentation of Wound Healing Using Monochromatic Infrared Energy. Exploration of a New Technology for Wound Management. Advances in Wound Care, 12, 35-40.
[89]
Schramm, M.J., Warner, D., Hardesty, R.A. and Oberg, K.C. (2003) A Unique Combination of Infrared and Microwave Radiation Accelerates Wound Healing. PlasticandReconstructiveSurgery, 111, 258-266. https://doi.org/10.1097/01.prs.0000033065.10876.2e
[90]
Yasunaga, Y., Matsuo, K., Tanaka, Y. and Yuzuriha, S. (2017) Near-Infrared Irradiation Increases Length of Axial Pattern Flap Survival in Rats. Eplasty, 17, e26.
[91]
Bäumler, W., Abels, C., Karrer, S., Weiß, T., Messmann, H., Landthaler, M., etal. (1999) Photo-Oxidative Killing of Human Colonic Cancer Cells Using Indocyanine Green and Infrared Light. BritishJournalofCancer, 80, 360-363. https://doi.org/10.1038/sj.bjc.6690363
[92]
Orenstein, A., Kostenich, G., Kopolovic, Y., Babushkina, T. and Malik, Z. (1999) Enhancement of ALA‐PDT Damage by IR-Induced Hyperthermia on a Colon Carcinoma Model. PhotochemistryandPhotobiology, 69, 703-707. https://doi.org/10.1111/j.1751-1097.1999.tb03350.x
[93]
Dees, C., Harkins, J., Petersen, M.G., Fisher, W.G. and Wachter, E.A. (2002) Treatment of Murine Cutaneous Melanoma with near Infrared Light. PhotochemistryandPhotobiology, 75, 296-301. https://doi.org/10.1562/0031-8655(2002)075<0296:tomcmw>2.0.co;2
[94]
Tanaka, Y., Tatewaki, N., Nishida, H., Eitsuka, T., Ikekawa, N. and Nakayama, J. (2012) Non-Thermal Dna Damage of Cancer Cells Using Near-Infrared Irradiation. CancerScience, 103, 1467-1473. https://doi.org/10.1111/j.1349-7006.2012.02310.x
[95]
Karu, T. (1999) Primary and Secondary Mechanisms of Action of Visible to Near-IR Radiation on Cells. JournalofPhotochemistryandPhotobiologyB: Biology, 49, 1-17. https://doi.org/10.1016/s1011-1344(98)00219-x
[96]
Tafur, J. and Mills, P.J. (2008) Low-Intensity Light Therapy: Exploring the Role of Redox Mechanisms. PhotomedicineandLaserSurgery, 26, 323-328. https://doi.org/10.1089/pho.2007.2184
[97]
Tirlapur, U.K. and König, K. (2001) Femtosecond Near-Infrared Laser Pulse Induced Strand Breaks in Mammalian Cells. CellularandMolecularBiology, 47, 131-134.
Bain, J.A., Rusch, H.P. and Kline, B.E. (1943) The Effect of Temperature Upon Ultraviolet Carcinogenesis with Wavelength 2,800-3,400A. Cancer Research, 3, 610-612.
[100]
Tanaka, Y., Motomura, H. and Jinno, M. (2016) Biological Defenses against Ultra-Violet, Visible Light, and Near-Infrared Exposure. OpticsandPhotonicsJournal, 6, 8-14. https://doi.org/10.4236/opj.2016.61002
[101]
Berg, M. (1989) Epidemiological Studies of Influence of Sunlight on the Skin. Photodermatology, 6, 80-84.
[102]
Finlayson, G.R., Sams, W.M. and Smith, J.G. (1966) Erythema Ab Igne: A Histopathological Study. JournalofInvestigativeDermatology, 46, 104-108. https://doi.org/10.1038/jid.1966.15
[103]
Arrington, J.H. (1979) Thermal Keratoses and Squamous Cell Carcinoma inSitu Associated with Erythema Ab Igne. ArchivesofDermatology, 115, 1226-1228. https://doi.org/10.1001/archderm.1979.04010100046019
[104]
Srinivasan, S., Pogue, B.W., Jiang, S., Dehghani, H., Kogel, C., Soho, S., etal. (2003) Interpreting Hemoglobin and Water Concentration, Oxygen Saturation, and Scattering Measured inVivo by Near-Infrared Breast Tomography. Proceedings of the National Academy of Sciences of the United States of America, 100, 12349-12354. https://doi.org/10.1073/pnas.2032822100
[105]
Nevskaya, N.A. and Chirgadze, Y.N. (1976) Infrared Spectra and Resonance Interactions of Amide-I and II Vibrations of Α-Helix. Biopolymers, 15, 637-648. https://doi.org/10.1002/bip.1976.360150404
[106]
Rawlings, A.V. (2006) Ethnic Skin Types: Are There Differences in Skin Structure and Function? InternationalJournalofCosmeticScience, 28, 79-93. https://doi.org/10.1111/j.1467-2494.2006.00302.x
[107]
Tsukahara, K., Fujimura, T., Yoshida, Y., Kitahara, T., Hotta, M., Moriwaki, S., etal. (2004) Comparison of Age-Related Changes in Wrinkling and Sagging of the Skin in Caucasian Females and in Japanese Females. InternationalJournalofCosmeticScience, 26, 314-314. https://doi.org/10.1111/j.1467-2494.2004.00245_5.x
[108]
Odunze, M., Rosenberg, D.S. and Few, J.W. (2008) Periorbital Aging and Ethnic Considerations: A Focus on the Lateral Canthal Complex. PlasticandReconstructiveSurgery, 121, 1002-1008. https://doi.org/10.1097/01.prs.0000299381.40232.79
[109]
Jones, C.S. (1988) Development of Neuroendocrine (Merkel Cell) Carcinoma Mixed with Squamous Cell Carcinoma in Erythema Ab Igne. ArchivesofDermatology, 124, 110-113. https://doi.org/10.1001/archderm.1988.01670010074024
[110]
Hewitt, J.B., Sherif, A., Kerr, K.M. and Stankler, L. (1993) Merkel Cell and Squamous Cell Carcinomas Arising in Erythema Ab Igne. BritishJournalofDermatology, 128, 591-592. https://doi.org/10.1111/j.1365-2133.1993.tb00247.x
[111]
van Veen, R.L.P., Sterenborg, H.J.C.M., Pifferi, A., Torricelli, A., Chikoidze, E. and Cubeddu, R. (2005) Determination of Visible Near-IR Absorption Coefficients of Mammalian Fat Using Time-and Spatially Resolved Diffuse Reflectance and Transmission Spectroscopy. JournalofBiomedicalOptics, 10, Article ID: 054004. https://doi.org/10.1117/1.2085149
[112]
Tsai, C.H., Chen, J.C. and Wang, W.J. (2001) Near-Infrared Absorption Property of Biological Soft Tissue Constituents. Journal of Medical and Biological Engineering, 21, 7-14.