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消化道微生物对宠物健康的影响研究进展
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Abstract:
由于生活方式的相似性和持续的密切社会互动，人类和动物会经历许多相同的、受肠道菌群影响的多因素疾病。与微生物代谢物的生理相互作用遍及全身，几乎影响动物健康的方方面面。微生物组和代谢物组可以作为疾病风险和进展的生物标志物，也可以作为预防和治疗这些疾病的治疗靶点。本文重点介绍了肠道微生物对以猫和狗为代表的宠物胃肠道、行为、心血管和免疫健康的影响，旨在为利用宠物微生物实现疾病预防和治疗提供新思路。
Due to behavioral similarities and ongoing close social interactions, humans and animals experience many shared multifactorial diseases influenced by gut microbiota. Physiological interactions with microbial metabolites extend throughout the body, affecting nearly every aspect of animal health. The microbiome and microbiota can serve as biomarkers of disease risk and progression, as well as therapeutic targets for the prevention and treatment of these diseases. This article focuses on the impact of gut microbiota on gastrointestinal, behavioral, cardiovascular, and immune health in companion animals, particularly cats and dogs, aiming to provide new insights into the use of pet microbiota for disease prevention and treatment.
| [1] | Fong, I.W. (2017) Animals and Mechanisms of Disease Transmission. In: Emerging Zoonoses, Springer, 15-38. https://doi.org/10.1007/978-3-319-50890-0_2 |
| [2] | Rindels, J.E. and Loman, B.R. (2024) Gut Microbiome—The Key to Our Pets’ Health and Happiness? Animal Frontiers, 14, 46-53. https://doi.org/10.1093/af/vfae015 |
| [3] | Kuthyar, S. and Reese, A.T. (2021) Variation in Microbial Exposure at the Human-Animal Interface and the Implications for Microbiome-Mediated Health Outcome. mSystems, 6, e00567-21. https://doi.org/10.1128/msystems.00567-21 |
| [4] | Hou, K., Wu, Z.X., Chen, X.Y., et al. (2022) Microbiota in Health and Diseases. Signal Transduction and Targeted Therapy, 7, Article No. 135. https://doi.org/10.1038/s41392-022-00974-4 |
| [5] | AlShawaqfeh, M., Wajid, B., Minamoto, Y., Markel, M., Lidbury, J., Steiner, J., et al. (2017) A Dysbiosis Index to Assess Microbial Changes in Fecal Samples of Dogs with Chronic Inflammatory Enteropathy. FEMS Microbiology Ecology, 93, fix136. https://doi.org/10.1093/femsec/fix136 |
| [6] | Tian, T.T., Zhao, J.H., Yang, J., et al. (2016) Molecular Characterization of Clostridium Difficile Isolates from Human Subjects and the Environment. PLOS ONE, 11, e0151964. https://doi.org/10.1371/journal.pone.0151964 |
| [7] | Chaitman, J., Ziese, A., Pilla, R., Minamoto, Y., Blake, A.B., Guard, B.C., et al. (2020) Fecal Microbial and Metabolic Profiles in Dogs with Acute Diarrhea Receiving Either Fecal Microbiota Transplantation or Oral Metronidazole. Frontiers in Veterinary Science, 7, Article 192. https://doi.org/10.3389/fvets.2020.00192 |
| [8] | Guard, B.C., Honneffer, J.B., Jergens, A.E., Jonika, M.M., Toresson, L., Lawrence, Y.A., et al. (2019) Longitudinal Assessment of Microbial Dysbiosis, Fecal Unconjugated Bile Acid Concentrations, and Disease Activity in Dogs with Steroid-Responsive Chronic Inflammatory Enteropathy. Journal of Veterinary Internal Medicine, 33, 1295-1305. https://doi.org/10.1111/jvim.15493 |
| [9] | Sung, C., Pilla, R., Marsilio, S., Chow, B., Zornow, K.A., Slovak, J.E., et al. (2023) Fecal Concentrations of Long-Chain Fatty Acids, Sterols, and Unconjugated Bile Acids in Cats with Chronic Enteropathy. Animals, 13, Article 2753. https://doi.org/10.3390/ani13172753 |
| [10] | Manchester, A.C., Webb, C.B., Blake, A.B., Sarwar, F., Lidbury, J.A., Steiner, J.M., et al. (2019) Long-Term Impact of Tylosin on Fecal Microbiota and Fecal Bile Acids of Healthy Dogs. Journal of Veterinary Internal Medicine, 33, 2605-2617. https://doi.org/10.1111/jvim.15635 |
| [11] | Stavroulaki, E.M., Suchodolski, J.S., Pilla, R., Fosgate, G.T., Sung, C., Lidbury, J.A., et al. (2021) Short-and Long-Term Effects of Amoxicillin/Clavulanic Acid or Doxycycline on the Gastrointestinal Microbiome of Growing Cats. PLOS ONE, 16, e0253031. https://doi.org/10.1371/journal.pone.0253031 |
| [12] | Stokes, J.E., Price, J.M. and Whittemore, J.C. (2017) Randomized, Controlled, Crossover Trial of Prevention of Clindamycin-Induced Gastrointestinal Signs Using a Synbiotic in Healthy Research Cats. Journal of Veterinary Internal Medicine, 31, 1406-1413. https://doi.org/10.1111/jvim.14795 |
| [13] | Lin, H., Guo, Q., Wen, Z., Tan, S., Chen, J., Lin, L., et al. (2021) The Multiple Effects of Fecal Microbiota Transplantation on Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Patients with Anxiety and Depression Behaviors. Microbial Cell Factories, 20, Article No. 233. https://doi.org/10.1186/s12934-021-01720-1 |
| [14] | Whittemore, J.C., Moyers, T.D. and Price, J.M. (2019) Randomized, Controlled, Crossover Trial of Prevention of Antibiotic-Induced Gastrointestinal Signs Using a Synbiotic Mixture in Healthy Research Dogs. Journal of Veterinary Internal Medicine, 33, 1619-1626. https://doi.org/10.1111/jvim.15553 |
| [15] | Kubinyi, E., Bel Rhali, S., Sándor, S., Szabó, A. and Felföldi, T. (2020) Gut Microbiome Composition Is Associated with Age and Memory Performance in Pet Dogs. Animals, 10, Article 1488. https://doi.org/10.3390/ani10091488 |
| [16] | Mondo, E., Barone, M., Soverini, M., D'Amico, F., Cocchi, M., Petrulli, C., et al. (2020) Gut Microbiome Structure and Adrenocortical Activity in Dogs with Aggressive and Phobic Behavioral Disorders. Heliyon, 6, e03311. https://doi.org/10.1016/j.heliyon.2020.e03311 |
| [17] | Kirchoff, N.S., Udell, M.A.R. and Sharpton, T.J. (2019) The Gut Microbiome Correlates with Conspecific Aggression in a Small Population of Rescued Dogs (Canis familiaris). Peer Journal, 7, e6103. https://doi.org/10.7717/peerj.6103 |
| [18] | Li, Q., Larouche-Lebel, É., Loughran, K.A., Huh, T.P., Suchodolski, J.S. and Oyama, M.A. (2021) Metabolomics Analysis Reveals Deranged Energy Metabolism and Amino Acid Metabolic Reprogramming in Dogs with Myxomatous Mitral Valve Disease. Journal of the American Heart Association, 10, e018923. https://doi.org/10.1161/jaha.120.018923 |
| [19] | Karlin, E.T., Rush, J.E. and Freeman, L.M. (2019) A Pilot Study Investigating Circulating Trimethylaminen-Oxide and Its Precursors in Dogs with Degenerative Mitral Valve Disease with or without Congestive Heart Failure. Journal of Veterinary Internal Medicine, 33, 46-53. https://doi.org/10.1111/jvim.15347 |
| [20] | Li, Q., Larouche-Lebel, É., Loughran, K.A., Huh, T.P., Suchodolski, J.S. and Oyama, M.A. (2021) Gut Dysbiosis and Its Associations with Gut Microbiota-Derived Metabolites in Dogs with Myxomatous Mitral Valve Disease. mSystems, 6, e00111-e00121. https://doi.org/10.1128/msystems.00111-21 |
| [21] | Soontararak, S., Chow, L., Johnson, V., Coy, J., Webb, C., Wennogle, S., et al. (2019) Humoral Immune Responses against Gut Bacteria in Dogs with Inflammatory Bowel Disease. PLOS ONE, 14, e0220522. https://doi.org/10.1371/journal.pone.0220522 |
| [22] | Rossi, G., Pengo, G., Galosi, L., et al. (2020) Effects of the Probiotic Mixture Slab51® (SivoMixx®) as Food Supplement in Healthy Dogs: Evaluation of Fecal Microbiota, Clinical Parameters and Immune Function. Frontiers in Veterinary Science, 7, Article 613. https://doi.org/10.3389/fvets.2020.00613 |
| [23] | Pahumunto, N., Duangnumsawang, Y. and Teanpaisan, R. (2022) Effects of Potential Probiotics on the Expression of Cytokines and Human β-Defensins in Human Gingival Epithelial Cells and in Vivo Efficacy in a Dog Model. Archives of Oral Biology, 142, Article 105513. https://doi.org/10.1016/j.archoralbio.2022.105513 |
| [24] | He, S., Yang, K., Wen, J., Kuang, T., Cao, Z., Zhang, L., et al. (2023) Antimicrobial Peptides Relieve Transportation Stress in Ragdoll Cats by Regulating the Gut Microbiota. Metabolites, 13, Article 326. https://doi.org/10.3390/metabo13030326 |
