Objective: To investigate the risk factors and blood type analysis of primary acute angle-closure glaucoma. Methods: A retrospective analysis of 615 patients with primary angle-closure glaucoma admitted to the Affiliated Hospital of Youjiang Medical College for Nationalities from January 2015 to December 2024, and 2696 patients diagnosed with age-related cataract in the same period were used as the control group. The age, gender, family history of glaucoma and blood type distribution characteristics of the two groups were observed. Results: There were 143 male patients in the PACG group, accounting for 23.25% of the total number, and 472 female patients, accounting for 76.75% of the total number, with a male to female ratio of 0.30:1. There were 1204 male patients in the control group, accounting for 44.66% of the total number, and 1492 female patients, accounting for 55.34% of the total number, with a male to female ratio of 0.81:1. The difference between the two groups was statistically significant (P < 0.05). The mean age of PACG group was 64.04 ± 10.19. Patients in the 60 - 69 age group were the most, accounting for 37.72% of the total number; followed by 70 - 79 years old and 50 - 59 years old, accounting for 26.34% and 22.44% of the total number, respectively. In the control group, the mean age was 70.44 ± 8.67. The patients in the 70 - 79 age group were the most, accounting for 42.88% of the total number, followed by the 60 - 69 age group, accounting for 31.42% of the total number. The difference between the two groups was statistically significant (P < 0.05). There were 86 cases with family history of glaucoma in the PACG group, and no family history of glaucoma in the control group. The difference between the two groups was statistically significant (P < 0.05). The distribution of ABO blood group in PACG group: O type (n = 296, 48.13%) > B type (n = 173, 28.13%) > A type (n = 122, 19.84%) > AB type (n = 24, 3.90%). The distribution of ABO blood group in the control group: O type (n = 1320, 48.96%) > B type (n = 708, 26.26%) > A type (n = 533, 19.77%) > AB type (n = 135, 5.01%). The results of single factor analysis showed that there was no significant difference (P > 0.05). Conclusion: Middle-aged and elderly women with a family history of glaucoma are high-risk factors for PACG. Whether blood type is related to the pathogenesis of glaucoma still needs further discussion. We should focus on people with high-risk factors for PACG, and try to achieve early prevention, early
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