Application Value of Multimodal Magnetic Resonance Imaging in Evaluating the Rehabilitation Effect of rTMS Combined with Cognitive Training on Cognitive Impairment in Patients with TBI
Objective: To explore the clinical application of multimodal magnetic resonance imaging in evaluating the effects of rTMS combined with cognitive training on the rehabilitation of cognitive impairment in patients with TBI. Methods: A prospective selection of 166 patients with cognitive dysfunction after traumatic brain injury who were in our hospital from January 2018 to January 2020 were divided into observation group and control group according to the principle of randomization, with 83 cases in each group; the former was rTMS + cognitive training, control group cognitive training, observe and compare the changes of GCS score, MRSI examination Cho/Cr, NAA/Cr ratio, cognitive dysfunction score, cognitive impairment grading scale and modified Barthel index. Results: The GCS score, Cho/Cr and NAA/Cr ratios of the observation group were significantly lower than those of the control group, while the cognitive dysfunction score, cognitive impairment rating scale and modified Barthel index were better than those of the control group (P < 0.05). Conclusion: rTMS can improve the rehabilitation effect of patients with cognitive dysfunction after brain trauma, and multimodal magnetic resonance imaging can play a good role in evaluation.
References
[1]
Stein, D.M., Feather, C.B. and Napolitano, L.M. (2017) Traumatic Brain Injury Advances. Critical Care Clinics, 33, 1-13. https://doi.org/10.1016/j.ccc.2016.08.008
[2]
Fukuda, A.M., Adami, A., Pop, V., Bellone, J.A., Coats, J.S., Hartman, R.E., et al. (2013) Posttraumatic Reduction of Edema with Aquaporin-4 RNA Interference Improves Acute and Chronic Functional Recovery. Journal of Cerebral Blood Flow & Metabolism, 33, 1621-1632. https://doi.org/10.1038/jcbfm.2013.118
[3]
Capizzi, A., Woo, J. and Verduzco-Gutierrez, M. (2020) Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. Medical Clinics of North America, 104, 213-238. https://doi.org/10.1016/j.mcna.2019.11.001
[4]
Hugo, J. and Ganguli, M. (2014) Dementia and Cognitive Impairment: Epidemiology, Diagnosis, and Treatment. Clinics in Geriatric Medicine, 30, 421-442. https://doi.org/10.1016/j.cger.2014.04.001
[5]
Diana, M., Raij, T., Melis, M., Nummenmaa, A., Leggio, L. and Bonci, A. (2017) Rehabilitating the Addicted Brain with Transcranial Magnetic Stimulation. Nature Reviews Neuroscience, 18, 685-693. https://doi.org/10.1038/nrn.2017.113
[6]
Esmael, A., Elsherif, M., Elegezy, M. and Egilla, H. (2020) Cognitive Impairment and Neuropsychiatric Manifestations of Neurobrucellosis. Neurological Research, 43, 1-8. https://doi.org/10.1080/01616412.2020.1812805
[7]
Castaño-Leon, A.M., Cicuendez, M., Navarro, B., Paredes, I., Munarriz, P.M., Cepeda, S., et al. (2019) Longitudinal Analysis of Corpus Callosum Diffusion Tensor Imaging Metrics and Its Association with Neurological Outcome. Journal of Neurotrauma, 36, 2785-2802. https://doi.org/10.1089/neu.2018.5978
[8]
Kulkarni, P., Kenkel, W., Finklestein, S.P., Barchet, T.M., Ren, J., Davenport, M., et al. (2015) Use of Anisotropy, 3D Segmented Atlas, and Computational Analysis to Identify Gray Matter Subcortical Lesions Common to Concussive Injury from Different Sites on the Cortex. PLOS ONE, 10, e0125748. https://doi.org/10.1371/journal.pone.0125748
[9]
Vollstädt-Klein, S., Loeber, S., Kirsch, M., Bach, P., Richter, A., Bühler, M., et al. (2011) Effects of Cue-Exposure Treatment on Neural Cue Reactivity in Alcohol Dependence: A Randomized Trial. Biological Psychiatry, 69, 1060-1066. https://doi.org/10.1016/j.biopsych.2010.12.016
[10]
Ponsford, J., Alway, Y. and Gould, K.R. (2018) Epidemiology and Natural History of Psychiatric Disorders after TBI. The Journal of Neuropsychiatry and Clinical Neurosciences, 30, 262-270. https://doi.org/10.1176/appi.neuropsych.18040093
[11]
Juengst, S.B., Kumar, R.G. and Wagner, A.K. (2017) A Narrative Literature Review of Depression Following Traumatic Brain Injury: Prevalence, Impact, and Management Challenges. Psychology Research and Behavior Management, 10, 175-186. https://doi.org/10.2147/prbm.s113264
[12]
Nordhaug, L.H., Hagen, K., Vik, A., Stovner, L.J., Follestad, T., Pedersen, T., et al. (2018) Headache Following Head Injury: A Population-Based Longitudinal Cohort Study (HUNT). The Journal of Headache and Pain, 19, Article No. 8. https://doi.org/10.1186/s10194-018-0838-2
[13]
Ponomarenko, A.I., Tyrtyshnaia, A.A., Pislyagin, E.A., Dyuizen, I.V., Sultanov, R.M. and Manzhulo, I.V. (2021) N-Docosahexaenoylethanolamine Reduces Neuroinflammation and Cognitive Impairment after Mild Traumatic Brain Injury in Rats. Scientific Reports, 11, Article No. 756. https://doi.org/10.1038/s41598-020-80818-9
[14]
Sit, J.W., Chair, S.Y., Choi, K., Chan, C.W., Lee, D.T., Chan, A.W., et al. (2016) Do Empowered Stroke Patients Perform Better at Self-Management and Functional Recovery after a Stroke? A Randomized Controlled Trial. Clinical Interventions in Aging, 11, 1441-1450. https://doi.org/10.2147/cia.s109560
[15]
Deng, Z., Lisanby, S.H. and Peterchev, A.V. (2013) Electric Field Depth-Focality Tradeoff in Transcranial Magnetic Stimulation: Simulation Comparison of 50 Coil Designs. Brain Stimulation, 6, 1-13. https://doi.org/10.1016/j.brs.2012.02.005
[16]
Fox, M.D., Halko, M.A., Eldaief, M.C. and Pascual-Leone, A. (2012) Measuring and Manipulating Brain Connectivity with Resting State Functional Connectivity Magnetic Resonance Imaging (fcMRI) and Transcranial Magnetic Stimulation (TMS). NeuroImage, 62, 2232-2243. https://doi.org/10.1016/j.neuroimage.2012.03.035
[17]
Ozdemir, R.A., Tadayon, E., Boucher, P., Momi, D., Karakhanyan, K.A., Fox, M.D., et al. (2020) Individualized Perturbation of the Human Connectome Reveals Reproducible Biomarkers of Network Dynamics Relevant to Cognition. Proceedings of the National Academy of Sciences of the United States of America, 117, 8115-8125. https://doi.org/10.1073/pnas.1911240117
[18]
Hallett, M. (2007) Transcranial Magnetic Stimulation: A Primer. Neuron, 55, 187-199. https://doi.org/10.1016/j.neuron.2007.06.026
[19]
Nuttall, A.G., Paton, K.M. and Kemp, A.M. (2018) To What Extent Are GCS and AVPU Equivalent to Each Other When Assessing the Level of Consciousness of Children with Head Injury? A Cross-Sectional Study of UK Hospital Admissions. BMJ Open, 8, e023216. https://doi.org/10.1136/bmjopen-2018-023216
[20]
Blackburn, D.J., Bafadhel, L., Randall, M. and Harkness, K.A. (2012) Cognitive Screening in the Acute Stroke Setting. Age and Ageing, 42, 113-116. https://doi.org/10.1093/ageing/afs116
