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全身免疫炎症指数与房颤射频消融术后复发的相关性研究
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Abstract:
目的：探讨全身免疫炎症指数(SII)与房颤射频消融术后复发的相关性。方法：回顾性研究，选择2020年8月~2023年6月在青岛大学附属医院500例做过房颤射频消融术患者，术后接受为期1年的随访，随访期间重点观察患者复发情况，将其分为复发组、未复发组。结果：参加研究的500例房颤患者全部实施射频消融术，在这项研究中的500位患者中，术后12个月的随访中，出现123例(24.6%)患者在房颤射频消融术后发生早期复发。相较于非复发组，房颤复发组患者术前全身免疫炎症指数(SII)明显升高。绘制ROC曲线，将房颤患者SII水平和是否复发作为横纵坐标绘制曲线，分析结果显示，确定房颤复发最佳截断值为386.756，其灵敏度为77.24%，特异度为68.17%，具有较好的诊断价值。多因素Logistic回归分析显示，SII是射频消融术后房颤复发的独立预测因子。结论：全身免疫炎症指数可以作为一种房颤复发的血清标志物，术前高水平SII提示射频消融术后具有较高的房颤复发风险。
Objective: To investigate the correlation between systemic immune inflammatory index (SII) and recurrence after radiofrequency ablation for atrial fibrillation. Methods: A retrospective study was conducted to select 500 patients who had undergone radiofrequency ablation for atrial fibrillation in the Affiliated Hospital of Qingdao University from August 2020 to June 2023, and received a 1-year follow-up after the procedure, during which the patients were divided into recurrence and non-recurrence groups by focusing on recurrence. Results: All 500 patients with atrial fibrillation who participated in the study underwent radiofrequency ablation. Of the 500 patients in this study, 123 patients (24.6%) experienced early recurrence after radiofrequency ablation of atrial fibrillation at the 12-month postoperative follow-up. The preoperative systemic immunoinflammatory index (SII) was significantly higher in patients in the AF recurrence group compared with the nonrecurrence group. The ROC curve was plotted, and the SII level and whether recurrence occurred in AF patients were plotted as the horizontal and vertical coordinates. The results of the analysis showed that the optimal cut-off value for determining AF recurrence was 386.756, and its sensitivity was 77.24% and specificity was 68.17%, which had a good diagnostic value. Multifactorial logistic regression analysis showed that SII was an independent predictor of AF recurrence after radiofrequency ablation. Conclusion: Systemic immunoinflammatory index can be used as a serum marker for AF recurrence, and high levels of preoperative SII suggest a high risk of AF recurrence after radiofrequency ablation.
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