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纳米材料在溃疡性结肠炎治疗中的创新策略与应用前景
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Abstract:
溃疡性结肠炎是一种慢性炎症性肠病，其病因尚未完全明确，治疗手段有限，给患者带来了较大的生活困扰和健康风险。近年来，随着纳米技术的发展，纳米材料因其独特的物理化学性质和良好的生物相容性，逐渐成为溃疡性结肠炎治疗的新兴策略。当前，纳米材料在靶向药物传递、抗炎作用、康复辅助以及再生医学等领域的应用现状显示出良好的前景，但仍存在一些挑战和问题亟待解决。本文旨在综述纳米材料在溃疡性结肠炎治疗中的应用进展，探讨其潜在的创新策略，并展望未来的应用前景，以期为相关研究提供参考和启示。
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with incompletely understood etiology and limited therapeutic options, imposing substantial lifestyle burdens and health risks on patients. In recent years, advancements in nanotechnology have positioned nanomaterials as a promising strategy for UC treatment due to their unique physicochemical properties and excellent biocompatibility. Current applications of nanomaterials in targeted drug delivery, anti-inflammatory interventions, rehabilitation support, and regenerative medicine demonstrate significant potential. However, persisting challenges, such as biocompatibility optimization, precise targeting, and long-term safety evaluation, require urgent resolution. This review systematically summarizes recent progress in nanomaterial-based UC therapies, explores innovative strategies to overcome existing limitations, and outlines future directions to advance clinical translation. The findings aim to provide valuable insights and references for interdisciplinary research in this evolving field.
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