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针灸早期干预主观认知下降的临床应用与机制探析
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Abstract:
主观认知下降通常是AD患者最早被发现的临床症状，是我国老年人的常见病、多发病。对SCD患者的早期干预有助于延缓患者转化为MCI及AD的时间，对减少AD的发病率有着重要意义。目前西医尚无完善的SCD治疗方案，而中医对SCD的病因病机有着相对完善的认知，其中针灸疗法对SCD有着明确的治疗效果，通过调节脏腑、补虚泻实、头体针相结合等方法可以有效的改善患者的认知功能，充分的发挥针灸“治未病”的优势。现代研究发现，针灸治疗SCD的作用机制包括改善海马结构、改善AD相关生物标志物、调节肠道菌群等多个方面。本文综合探讨了中医对SCD的认知及针灸的临床应用与机制研究进展，总结了目前针灸治疗SCD的研究现状，以期望为完善针灸治疗SCD的治疗方案提供一定的帮助。
Subjective cognitive decline (SCD) is usually the earliest clinical symptom detected in AD patients, and it is a common and frequent disease among the elderly in China. Early intervention for SCD patients can help delay the transformation of patients into MCI and AD, which is of great significance in reducing the incidence of AD. At present, there is no perfect treatment program for SCD in western medicine, while Chinese medicine has a relatively perfect knowledge of the etiology and pathogenesis of SCD, in which acupuncture therapy has a clear therapeutic effect on SCD, through the regulation of internal organs, supplementing deficiency and diarrhea, and the combination of head and body needles, etc., which can effectively improve the cognitive function of the patients, and fully utilize the advantages of acupuncture in the “treatment of the future disease”. The advantages of acupuncture are fully utilized. Modern research has found that the mechanism of acupuncture in treating SCD includes improving hippocampal structure, improving AD-related biomarkers, and regulating intestinal flora. In this paper, we comprehensively discussed the knowledge of Chinese medicine on SCD and the clinical application and mechanism of acupuncture, and summarized the current research status of acupuncture treatment of SCD, in the hope of providing some help to improve the treatment plan of acupuncture treatment of SCD.
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