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“微生物群–肠–脑轴”理论下探讨中医药治疗失眠的研究进展
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Abstract:
失眠在临床上是一种常见的疾病，随着社会压力的增加，失眠患者的数量也是急速上升，这严重影响患者的生存质量，越来越庞大的失眠群体更有可能会影响社会的发展，这便使得临床医者不断深入寻求治疗失眠症的方法。传统治疗失眠的药物存在副作用大、依赖性高等问题，而中医药作为一种安全有效的替代疗法，逐渐受到关注。近年来，有研究表明，肠道微生物菌群通过“微生物群–肠–脑轴”参与了失眠的发生机制，而中医药可以通过调节肠道菌群的从而改善睡眠，本文章将基于微生物–肠–脑轴理论探讨中医药治疗失眠的研究进展，以为临床治疗失眠提供新思路。
Insomnia is a common clinical disorder. With increasing social stress, the number of insomnia patients has risen rapidly, severely affecting their quality of life. The growing population of insomnia sufferers may further impact social development, prompting clinicians to continuously explore more effective treatments. Conventional insomnia medications often come with significant side effects and high dependency risks, whereas Traditional Chinese Medicine (TCM), as a safe and effective alternative therapy, has gradually gained attention. Recent studies suggest that gut microbiota participates in the pathogenesis of insomnia through the “microbiota-gut-brain axis,” and TCM can improve sleep by modulating gut microbiota. This article reviews the research progress of TCM in treating insomnia based on the microbiota-gut-brain axis theory, aiming to provide new insights for clinical insomnia treatment.
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