全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

中药涂擦在乳腺癌放射性皮炎治疗中的研究进展
Research Progress of Chinese Medicine Application in the Treatment of Radiation Dermatitis in Breast Cancer

DOI: 10.12677/tcm.2025.146388, PP. 2629-2636

Keywords: 乳腺癌,放射性皮炎,中药涂擦,皮肤粘膜修复
Mammary Cancer
, Radiodermatitis, Traditional Chinese Medicine Coating, Skin and Mucous Membrane Repair

Full-Text   Cite this paper   Add to My Lib

Abstract:

乳腺癌放射性皮炎的发生对患者的生活质量造成了严重影响,西药治疗常伴有较明显的副作用。中药涂擦作为一种有效的中医外治手段,尤其是清热解毒药、活血化瘀药和补益药,展现了良好的临床应用潜力和疗效。中药的部分有效成分通过皮肤粘膜修复和调节微环境,能够有效缓解放射性皮炎的症状。未来的研究应聚焦于中药涂擦临床试验的开展、中药与现代科技的结合,以及中药制剂的标准化与规范化,以进一步提升中药在这一领域的应用效果和科学依据。
The occurrence of radiation dermatitis in breast cancer has a serious impact on the quality of life of patients, and western medicine treatment is often accompanied by obvious side effects. As an effective means of traditional Chinese medicine external treatment, especially heat clearing and detoxifying medicine, blood circulation and blood stasis medicine and tonic medicine, it shows good clinical application potential and curative effect. Some of the active ingredients of traditional Chinese medicine can effectively relieve the symptoms of radiation dermatitis by repairing the skin and mucous membrane and regulating the microenvironment. Future research should focus on the development of clinical trials of TCM rubbing, the combination of TCM and modern technology, and the standardization and standardization of TCM preparations, so as to further improve the application effect and scientific basis of TCM in this field.

References

[1]  赵承启, 邹伟. 中医药调控细胞焦亡干预缺血性脑卒中的研究进展[J]. 湖南中医药大学学报, 2023, 43(9): 1742-1748.
[2]  潘小丽, 周丽, 王丹, 等. 电针“足三里”对功能性消化不良大鼠胃排空及自噬信号通路的影响[J]. 针刺研究, 2019, 44(7): 486-491.
[3]  崔鑫, 赵天易, 赵美丹, 等. 针对乳腺癌患者症状群的针灸干预方案思路探讨[J]. 天津中医药大学学报, 2024, 43(3): 247-252.
[4]  王蕾. 症状管理教育在乳腺癌化疗患者疲乏-抑郁-睡眠障碍症状群中的应用效果研究[D]: [硕士学位论文]. 天津: 天津中医药大学, 2021.
[5]  Roy, I., Fortin, A. and Larochelle, M. (2001) The Impact of Skin Washing with Water and Soap during Breast Irradiation: A Randomized Study. Radiotherapy and Oncology, 58, 333-339.
https://doi.org/10.1016/s0167-8140(00)00322-4
[6]  彭安林, 牛云辉, 张路, 等. 含低相对分子质量壳聚糖凝胶对大鼠放射性皮炎的防护作用[J]. 中国医院药学杂志, 2015, 35(7): 590-593.
[7]  Ho, A.Y., Olm-Shipman, M., Zhang, Z., Siu, C.T., Wilgucki, M., Phung, A., et al. (2018) A Randomized Trial of Mometasone Furoate 0.1% to Reduce High-Grade Acute Radiation Dermatitis in Breast Cancer Patients Receiving Postmastectomy Radiation. International Journal of Radiation Oncology Biology Physics, 101, 325-333.
https://doi.org/10.1016/j.ijrobp.2018.02.006
[8]  戴晓波. 重组牛碱性成纤维细胞生长因子治疗Ⅱ度急性放射性皮炎[J]. 重庆医科大学学报, 2001(3): 337-339.
[9]  Wollina, U., Liebold, K. and Konrad, H. (2001) Treatment of Chronic Radiation Ulcers with Recombinant Platelet‐derived Growth Factor and a Hydrophilic Copolymer Membrane. Journal of the European Academy of Dermatology and Venereology, 15, 455-457.
https://doi.org/10.1046/j.1468-3083.2001.00348.x
[10]  Iervolino, V., Di Costanzo, G., Azzaro, R., Diodato, A.M., Di Macchia, C.A., Di Meo, T., et al. (2012) Platelet Gel in Cutaneous Radiation Dermatitis. Supportive Care in Cancer, 21, 287-293.
https://doi.org/10.1007/s00520-012-1635-0
[11]  Ryan Wolf, J., Gewandter, J.S., Bautista, J., Heckler, C.E., Strasser, J., Dyk, P., et al. (2019) Utility of Topical Agents for Radiation Dermatitis and Pain: A Randomized Clinical Trial. Supportive Care in Cancer, 28, 3303-3311.
https://doi.org/10.1007/s00520-019-05166-5
[12]  张翠红, 高琪, 马博敬, 等. 三乙醇胺乳膏防治头颈部恶性肿瘤放疗患者放射性皮炎的疗效及对心理状态的影响[J]. 临床误诊误治, 2024, 37(16): 56-60.
[13]  刘敏, 虞芬. 康复新液联合洁悠神预防放射性皮炎的疗效观察[J]. 天津药学, 2022, 34(1): 54-57.
[14]  陈紫红, 钟强, 陈永红. 放射性皮炎预防及管理临床实践指南的质量评价与内容分析[J]. 循证护理, 2021, 7(2): 151-156.
[15]  冯玉芳, 何文婷. 中药湿敷疗法在恶性肿瘤辅助治疗中的应用[J]. 中华养生保健, 2024, 42(22): 68-70.
[16]  陆锦龙, 张政, 翁敬锦, 等. 加味三黄汤冷冻液治疗鼻咽癌颈部急性放射性皮肤损伤的临床疗效观察[J]. 环球中医药, 2015, 8(S2): 1-2.
[17]  Guan, Q.X., Yang, H., Liu, Y.M., et al. (2023) Research Progress on Traditional Chinese Medicine Compounds Combined with External Therapy in Treatment of Hyperplasia of Mammary Glands. China Journal of Chinese Materia Medica, 48, 2856-2867.
[18]  Tao, L., Fu, J., Wang, F., Song, Y., Li, Y., Zhang, J., et al. (2024) The Application of Mirabilite in Traditional Chinese Medicine and Its Chemical Constituents, Processing Methods, Pharmacology, Toxicology and Clinical Research. Frontiers in Pharmacology, 14, Article ID: 1293097.
https://doi.org/10.3389/fphar.2023.1293097
[19]  Yan, W., Liu, L., Yang, T. and Yang, X. (2022) Traditional Chinese Medicine Paraffin Therapy: An Evidence-Based Overview from a Modern Medicine Perspective. Chinese Medicine, 17, Article No. 106.
https://doi.org/10.1186/s13020-022-00662-z
[20]  Lu, S., Wang, B., Wang, J., Guo, Y., Li, S., Zhao, S., et al. (2023) Moxibustion for the Treatment of Cancer and Its Complications: Efficacies and Mechanisms. Integrative Cancer Therapies, 22, Article ID: 1563513225.
https://doi.org/10.1177/15347354231198089
[21]  Zhang, Y., Zhang, R., Sun, C., Meng, D. and Chen, L. (2024) Non-Lactational Mastitis with Multiple Sinus Wounds Treated by Integrated Traditional Chinese and Western Medicine. Journal of Wound Care, 33, S4-S7.
https://doi.org/10.12968/jowc.2022.0050
[22]  雷丽, 王艳, 殷玉杰. 紫白黄芪膏防治急性放射性皮炎临床观察[J]. 光明中医, 2021, 36(3): 386-388.
[23]  许文婧, 马玥诗, 王佩, 等. 急性放射性皮炎的中药治疗进展[J]. 中国中医急症, 2023, 32(10): 1868-1871.
[24]  廖韵诺, 赵凯丽, 郭宏伟. 中药网络药理学的研究应用与挑战[J]. 中草药, 2024, 55(12): 4204-4213.
[25]  白姣姣, 阿丽亚·依拉木, 阿布都艾则孜·艾尔肯, 等. 中药复方及单体治疗结肠癌药效与机制研究进展[J]. 中国实验方剂学杂志, 2023, 29(4): 246-252.
[26]  杨露, 张永萍, 彭丽华. 中药及其外用制剂调控细胞因子促创面愈合的研究进展[J]. 中国中药杂志, 2021, 46(20): 5173-5184.
[27]  曹东阳. 疮灵液载入胶原促进慢性感染性创面愈合的实验与临床研究[D]: [硕士学位论文]. 南京: 南京中医药大学, 2014.
[28]  黄洁雅, 陈丽, 周忠志, 等. 解毒生肌膏对糖尿病溃疡大鼠创面局部IL-6、TNF-α表达的影响[J]. 中国中医基础医学杂志, 2021, 27(10): 1567-1571.
[29]  孟建霞. 徐旭英辨治慢性创面经验和回阳生肌膏对慢性创面巨噬细胞的影响[D]: [硕士学位论文]. 北京: 北京中医药大学, 2018.
[30]  Percival, S.L., McCarty, S.M. and Lipsky, B. (2015) Biofilms and Wounds: An Overview of the Evidence. Advances in Wound Care, 4, 373-381.
https://doi.org/10.1089/wound.2014.0557
[31]  阙华发, 张臻, 邢捷, 等. 中医药促进慢性难愈性创面愈合的机制研究[C]//中华中医药学会周围血管病分会2010年学术大会. 上海: 上海中医药大学附属龙华医院中医外科, 2010: 5.
[32]  李叔洪, 姜晓文, 辛秀, 等. 防腐生肌膏对基质金属蛋白酶变化的影响[J]. 动物医学进展, 2018, 39(10): 56-59.
[33]  邵佳一, 吴勉华, 马艳霞, 等. 细胞因子及相关信号通路在中药干预放射性肺损伤中的作用[J]. 中国实验方剂学杂志, 2023, 29(22): 244-253.
[34]  王玉, 张露, 汤磊磊, 等. 中医药调控肺癌辐射治疗作用机制研究进展[J]. 中国实验方剂学杂志, 2024, 30(8): 253-261.
[35]  马迪, 陈好, 王晨曦, 等. 二维液相色谱技术及其在中药研究中的应用[J]. 天津中医药大学学报, 2023, 42(4): 521-528.
[36]  董治国, 周容, 何金凤, 等. 膜分离技术在中药绿色制造中的应用与展望[J]. 中草药, 2024, 55(12): 4225-4234.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133