|
|
生命八要素与甲状腺疾病的关联研究进展
|
Abstract:
近年来，甲状腺疾病逐渐受到关注，但公众对于甲状腺疾病与健康相关行为方式的相关性关注度较低。甲状腺疾病与健康行为生活方式可能有密切联系，二者的相关性研究可能降低甲状腺癌的发生发展。本研究围绕生命八要素中八大因素探讨甲状腺疾病与健康生活行为方式的相关性，并从公共卫生二级预防的角度出发，提出甲状腺相关疾病的预防措施，降低甲状腺疾病发病率。研究表明，代谢相关要素可能通过炎症反应、氧化应激和胰岛素抵抗等机制，增加甲状腺功能异常的风险。不良生活方式与甲状腺结节及甲状腺癌的发生亦存在潜在相关性。这一关联揭示了心血管代谢健康与内分泌系统之间的潜在影响机制，为疾病的预防提供了新视角。
In recent years, thyroid diseases have gained attention, but the public remains less aware of the link between these diseases and health—related behaviors. Given the probable close correlation between them, studying this link may help reduce thyroid cancer incidence and progression. The translation of the sentence is: This study explores the correlation between thyroid diseases and healthy lifestyle behaviors based on the eight factors in Life’s Essential 8 from the viewpoint of public health’s secondary prevention, it proposes preventive measures for thyroid—related diseases to lower thyroid disease incidence rates. Studies show that metabolic factors may increase the risk of thyroid dysfunction through inflammation, oxidative stress, and insulin resistance. There’s also a potential link between unhealthy lifestyles and the occurrence of thyroid nodules and cancer. This relationship reveals a possible impact mechanism between cardiovascular metabolic health and the endocrine system, offering a new angle for disease prevention.
| [1] | Shah, N. (2021) Prevalence and Etiology of Thyroid Disease: A Review. Pure and Applied Biology, 10, 691-702. https://doi.org/10.19045/bspab.2021.100071 |
| [2] | 单忠艳, 滕卫平. 我国甲状腺疾病的防治现状, 对策及挑战[J]. 诊断学理论与实践, 2020, 19(4): 329-333. |
| [3] | Crafa, A., Calogero, A.E., Cannarella, R., Mongioi’, L.M., Condorelli, R.A., Greco, E.A., et al. (2021) The Burden of Hormonal Disorders: A Worldwide Overview with a Particular Look in Italy. Frontiers in Endocrinology, 12, Article 694325. https://doi.org/10.3389/fendo.2021.694325 |
| [4] | 中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组. 甲状腺疾病诊治指南——甲状腺功能减退症[J]. 中华内科杂志, 2007, 46(11): 967-971. |
| [5] | 于晓会, 单忠艳. 甲状腺结节病因学与流行病学再认识[J]. 中国实用外科杂志, 2010, 30(10): 840-842. |
| [6] | 朱砚, 李敬华, 王素莉, 等. 甲状腺结节病因及危险因素的研究进展[J]. 现代中西医结合杂志, 2016, 25(15): 1701-1703. |
| [7] | 李文钰, 黄薇. 体检中心甲状腺结节患者流行病学特征及危险因素调查分析[J]. 河北医药, 2019, 41(3): 456-459. |
| [8] | 卢燕红, 张荣新, 王圣应. 甲状腺结节3958例流行病学和临床特点分析[J]. 蚌埠医学院学报, 2017, 42(12): 1612-1614. |
| [9] | Gheriani, H. (2006) Update on Epidemiology Classification, and Management of Thyroid Cancer. Libyan Journal of Medicine, 1, 83-95. https://doi.org/10.3402/ljm.v1i1.4667 |
| [10] | Alvarado, P.Q. (2014) Tumores de la glándula de cowper. Elsevier. |
| [11] | Fang, X., Hu, R., Fei, S., Ding, Z., Zhao, J. and Shang, J. (2024) Associations between Cardiovascular Health and Low Thyroid Function among US Adults: A Population-Based Study. Frontiers in Endocrinology, 15, Article 1437386. https://doi.org/10.3389/fendo.2024.1437386 |
| [12] | 时学花, 陈伟, 董璐, 等. 2017年西安市城乡健康成人碘营养及甲状腺功能调查[J]. 中华地方病学杂志, 2019, 38(7): 554-558. |
| [13] | 何志坚, 谭羽灿, 徐国建, 等. 甲状腺结节发病原因多因素研究分析[J]. 岭南现代临床外科, 2019, 19(5): 555-558, 562. |
| [14] | 古力乃则尔∙阿不都外力, 孙丽, 黄佳, 等. 新疆地区成人碘营养和甲状腺功能调查[J]. 环境与职业医学, 2023, 40(12): 1419-1423, 1430. |
| [15] | 刘婷婷, 滕卫平. 中国国民碘营养现状与甲状腺疾病[J]. 中华内科杂志, 2017, 56(1): 62-64. |
| [16] | 赵树君, 田恩江, 孙富军, 等. 碘对诱发实验性自身免疫性甲状腺炎形成的影响[J]. 中国地方病防治杂志, 2002, 17(5): 267-271. |
| [17] | 罗玉玉. 不同剂量碘酸钾和碘化钾对大鼠缺碘性肿大甲状腺形态和功能的影响[D]: [硕士学位论文]. 天津: 天津医科大学, 2003. |
| [18] | 滕卫平. 碘营养与甲状腺疾病[J]. 内科理论与实践, 2010(2): 112-117. |
| [19] | Hu, C., Xu, Y., Wang, M., Cui, S., Zhang, H. and Lu, L. (2023) Bisphenol Analogues Induce Thyroid Dysfunction via the Disruption of the Thyroid Hormone Synthesis Pathway. Science of the Total Environment, 900, Article ID: 165711. https://doi.org/10.1016/j.scitotenv.2023.165711 |
| [20] | 朱浩, 王晓东. 甲状腺与脂肪组织间相互作用研究进展[J]. 南京医科大学学报(自然科学版), 2024, 44(4): 567-572. |
| [21] | Diniz, M.D.F.H.S., Beleigoli, A.M.R., Benseñor, I.M., Lotufo, P.A., Goulart, A.C. and Barreto, S.M. (2020) Association between TSH Levels within the Reference Range and Adiposity Markers at the Baseline of the Elsa-Brasil Study. PLOS ONE, 15, e0228801. https://doi.org/10.1371/journal.pone.0228801 |
| [22] | 潘霞明, 冉建民, 林燕珊, 等. 左甲状腺素联合阿托伐他汀治疗对甲减患者血脂的影响[J]. 临床心血管病杂志, 2015, 31(8): 879-882. |
| [23] | 许丹晴, 张淼, 周力, 等. Ⅱ型脱碘酶在甲状腺疾病中的研究进展[J]. 中国普通外科杂志, 2024, 33(5): 815-821. |
| [24] | 许娜, 刘馨璐, 汤蓉, 等. 不同流速对草鱼幼鱼甲状腺激素代谢的影响[J]. 淡水渔业, 2021, 51(5): 106-112. |
| [25] | 杨鑫宇, 高树新, 贾振伟. AMPK对线粒体质量的调控作用[J]. 中国细胞生物学学报, 2020, 42(5): 881-887. |
| [26] | 朱亚林, 王国庆. 递增负荷的力竭性运动对血清甲状腺激素的影响[J]. 标记免疫分析与临床, 2003, 10(1): 51-52. |
| [27] | Gasparoni, A., Autelli, M., Ravagni-Probizer, M., Bartoli, A., Regazzi-Bonora, M., Chirico, G., et al. (1998) Effect of Passive Smoking on Thyroid Function in Infants. European Journal of Endocrinology, 138, 379-382. https://doi.org/10.1530/eje.0.1380379 |
| [28] | 戴雨桑, 时立新. 吸烟与甲状腺功能减退症[J]. 国际内分泌代谢杂志, 2018, 38(6): 390-393. |
| [29] | 王秋红, 曾程程, 牟旆, 高连娣, 沈亚, 魏锐利. 香烟烟雾提取物及尼古丁诱导甲状腺相关眼病患者眼眶成纤维细胞氧化应激反应并上调NF-κB表达[J]. 第二军医大学学报, 2016, 37(10): 1239-1244. |
| [30] | 管莹, 高茜, 李雪梅, 等. 电子烟烟液体外毒理学评价用细胞筛选研究[J]. 中国烟草学报, 2018, 24(5): 84-90. |
| [31] | 王法欣, 王福茹, 宋保华. 睡眠不足对代谢和内分泌功能的影响[J]. 国外医学. 护理学分册, 2000(4): 168. |
| [32] | Laskar, P. and Singh, S.S. (2017) Melatonin Modulates Thyroid Hormones and Splenocytes Proliferation through Mediation of Its MT1 and MT2 Receptors in Hyperthyroid Mice. Proceedings of the Zoological Society, 71, 186-193. https://doi.org/10.1007/s12595-017-0244-9 |
| [33] | 孙琳歌, 欧阳松云, 孙培宗, 等. 重叠综合征合并甲状腺功能减退症致呼吸衰竭及心力衰竭一例[J]. 中华结核和呼吸杂志, 2014, 37(12): 939-941. |
| [34] | Teixeira, P.D.F.D.S., dos Santos, P.B. and Pazos-Moura, C.C. (2020) The Role of Thyroid Hormone in Metabolism and Metabolic Syndrome. Therapeutic Advances in Endocrinology and Metabolism, 11, 1-33. https://doi.org/10.1177/2042018820917869 |
| [35] | 彭丽, 顾明君. 甲状腺素治疗对亚临床甲状腺功能减退症患者血脂谱影响的Meta分析[J]. 第二军医大学学报, 2007, 28(5): 519-523. |
| [36] | 张萍, 张虹, 刘杰. 亚临床甲状腺功能减退对更年期高血压妇女动态血压的影响[J]. 重庆医学, 2014, 43(22): 2865-2867. |
| [37] | 连小兰. 甲状腺功能亢进症与妊娠[J]. 中国临床医生杂志, 2005, 33(10): 10-12. |
| [38] | 侯丽媛, 国伟. 亚临床甲状腺功能减退症与心血管疾病血栓形成相关性研究进展[J]. 临床医学进展, 2022, 12(9): 8170-8177. |
| [39] | 白梦坡, 穆耶赛尔·麦麦提明, 刘惠娟, 等. 原发性高血压患者亚临床甲状腺功能减退与中心动脉压相关指标及脉搏波速度之间的关系[J]. 临床心血管病杂志, 2022, 38(4): 318-322. |
| [40] | Ye, D., Cruz-López, E.O., Tu, H., Zlatev, I. and Danser, A.H.J. (2023) Targeting Angiotensinogen with n-Acetylgalactosamine-Conjugated Small Interfering RNA to Reduce Blood Pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 43, 2256-2264. https://doi.org/10.1161/atvbaha.123.319897 |
| [41] | 李明, 许丽颖, 魏兰涛.优质护理对甲亢合并糖尿病患者血糖控制和并发症的影响[J]. 黑龙江医学, 2022, 46(21): 2645-2647. |
| [42] | 郑茂. 甲状腺激素导致糖代谢异常机制的研究进展[J]. 临床与病理杂志, 2015, 35(2): 314-318. |
| [43] | 苏咏明, 黄萍, 傅明捷, 等. 老年2型糖尿病患者合并甲状腺疾病的436例回顾性分析[J]. 中国医药导报, 2012， 9(7): 25-27. |
| [44] | Wu, K., Zhou, Y., Ke, S., Huang, J., Gao, X., Li, B., et al. (2021) Lifestyle Is Associated with Thyroid Function in Subclinical Hypothyroidism: A Cross-Sectional Study. BMC Endocrine Disorders, 21, Article No. 112. https://doi.org/10.1186/s12902-021-00772-z |
| [45] | Huang, Y., Cai, L., Zheng, Y., Pan, J., Li, L., Zong, L., et al. (2019) Association between Lifestyle and Thyroid Dysfunction: A Cross-Sectional Epidemiologic Study in the She Ethnic Minority Group of Fujian Province in China. BMC Endocrine Disorders, 19, Article No. 83. https://doi.org/10.1186/s12902-019-0414-z |
| [46] | Starosz, A., Stożek, K., Opęchowska, A., Bossowski, F., Moniuszko, M., Grubczak, K., et al. (2024) Effect of Methimazole Treatment on Th1, Th17, and Th22 Lymphocytes in Pediatric Graves’ Disease Patients. Frontiers in Immunology, 15, Article 1431686. https://doi.org/10.3389/fimmu.2024.1431686 |
| [47] | Teng, W.P., et al. (2006) Effect of Iodine Intake on Thyroid Diseases in China. The New England Journal of Medicine, 354, 2783-2793. |
| [48] | Dardente, H., Hazlerigg, D.G. and Ebling, F.J.P. (2014) Thyroid Hormone and Seasonal Rhythmicity. Frontiers in Endocrinology, 5, Article 19. https://doi.org/10.3389/fendo.2014.00019 |
| [49] | 黎南中, 殷增掬, 何聿忠, 等. 108例甲状腺功能障碍患者全血9种元素相关性研究[J]. 广东微量元素科学, 1995(5): 34-38. |
| [50] | Han, H., Fu, X., Huang, J., Zhang, X. and Yu, J. (2020) PD-1/PD-L1 Affects Graves Progression through Lymphocytes on the Proliferation, Apoptosis and Inflammatory Cytokine Secretion of Thyroid Follicular Epithelial Cells. The Journal of Toxicological Sciences, 45, 701-711. https://doi.org/10.2131/jts.45.701 |
| [51] | Wiersinga, W.M. (2016) Clinical Relevance of Environmental Factors in the Pathogenesis of Autoimmune Thyroid Disease. Endocrinology and Metabolism, 31, 213-222. https://doi.org/10.3803/enm.2016.31.2.213 |
| [52] | Zheng, S., Liu, L., Liang, K., et al. (2024) Multi-Omics Insight into the Metabolic and Cellular Characteristics in the Pathogenesis of Hypothyroidism. Communications Biology, 7, Article No. 990. |
| [53] | Pitto, L., Gorini, F., Bianchi, F. and Guzzolino, E. (2020) New Insights into Mechanisms of Endocrine-Disrupting Chemicals in Thyroid Diseases: The Epigenetic Way. International Journal of Environmental Research and Public Health, 17, Article 7787. https://doi.org/10.3390/ijerph17217787 |
| [54] | Candler, T., Kessler, N.J., Gunasekara, C.J., Ward, K.A., James, P., Laritsky, E., et al. (2021) DNA Methylation at a Nutritionally Sensitive Region of the PAX8 Gene Is Associated with Thyroid Volume and Function in Gambian Children. Science Advances, 7, eabj1561. https://doi.org/10.1126/sciadv.abj1561 |
| [55] | Grogan, R.H., Mitmaker, E.J. and Clark, O.H. (2010) The Evolution of Biomarkers in Thyroid Cancer—From Mass Screening to a Personalized Biosignature. Cancers, 2, 885-912. https://doi.org/10.3390/cancers2020885 |
| [56] | Klubo-Gwiezdzinska, J., Burman, K.D., Van Nostrand, D. and Wartofsky, L. (2011) Levothyroxine Treatment in Pregnancy: Indications, Efficacy, and Therapeutic Regimen. Journal of Thyroid Research, 2011, Article ID: 843591. https://doi.org/10.4061/2011/843591 |
| [57] | Glinoer, D. (1997) The Regulation of Thyroid Function in Pregnancy: Pathways of Endocrine Adaptation from Physiology to Pathology. Endocrine Reviews, 18, 404-433. https://doi.org/10.1210/er.18.3.404 |
| [58] | Kalra, S., Agarwal, N., Aggarwal, R., Agarwal, S., Bajaj, S., Bantwal, G., et al. (2017) Patient-Centered Management of Hypothyroidism. Indian Journal of Endocrinology and Metabolism, 21, 475-477. https://doi.org/10.4103/ijem.ijem_93_17 |
| [59] | Marilena, C., Francesca, R., Valentina, M. (2017) MicroRNAs as Biomarkers in Thyroid Carcinoma. International Journal of Genomics, 2017, Article ID: 6496570. |
| [60] | Wylie, D., Beaudenon‐Huibregtse, S., Haynes, B.C., Giordano, T.J. and Labourier, E. (2016) Molecular Classification of Thyroid Lesions by Combined Testing for Mirna Gene Expression and Somatic Gene Alterations. The Journal of Pathology: Clinical Research, 2, 93-103. https://doi.org/10.1002/cjp2.38 |
| [61] | Géraldine, D., Journe, F. and Sven, S. (2019) Current and Future Markers for the Diagnosis of Thyroid Cancer. Clinical Oncology Research, 2, 2-4. |
| [62] | Habchi, Y., Himeur, Y., Kheddar, H., Boukabou, A., Atalla, S., Chouchane, A., et al. (2023) AI in Thyroid Cancer Diagnosis: Techniques, Trends, and Future Directions. Systems, 11, Article 519. https://doi.org/10.3390/systems11100519 |
| [63] | Carneiro, H.C., de Andrade Natal, R., Farias, E.C., Bastos, A.A., Guastapaglia, L., Bezerra, A.M.P.S., et al. (2024) Predictive Biomarkers in Thyroid Cancer in the Current Molecular-Morphology Paradigm. Surgical and Experimental Pathology, 7, Article No. 14. https://doi.org/10.1186/s42047-024-00157-1 |
| [64] | Li, H. and Wu, P. (2024) Epigenetics in Thyroid Cancer: A Bibliometric Analysis. Endocrine Connections, 13, e240087. https://doi.org/10.1530/ec-24-0087 |
| [65] | 陈芳, 吴凯, 徐明星, 等. 基于病例对照研究的甲状腺癌危险因素的Meta分析[J]. 中华地方病学杂志, 2017, 36(4): 250-256. |
