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组织胞浆菌病的诊治进展
Progress in the Diagnosis and Treatment of Histoplasmosis

DOI: 10.12677/acm.2025.1561925, PP. 1861-1868

Keywords: 组织胞浆菌,肺组织胞浆菌病,播散型,诊断,治疗
Histoplasma
, Pulmonary Histoplasmosis, Disseminated, Diagnosis, Treatment

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Abstract:

组织胞浆菌广泛存在于自然环境中,主要感染免疫功能低下的人群。该病通常引起肺部感染,严重时可发展为播散型,感染全身脏器。在我国主要流行于南方地区,发病率逐渐上升,且早期诊断及治疗较困难,为避免漏诊、误诊,现就组织胞浆菌病的流行病学、临床特征、诊断及治疗等诊治进展作一综述。
Histoplasma is widely present in the natural environment and primarily infects immunocompromised individuals. The disease typically causes pulmonary infection, which can progress to the disseminated form in severe cases, involving multiple organs throughout the body. In China, it is mainly prevalent in southern regions, with an increasing incidence. Early diagnosis and treatment are challenging. To avoid missed diagnosis and misdiagnosis, this review summarizes the recent advances in the epidemiology, clinical features, diagnosis, and treatment of histoplasmosis.

References

[1]  Araúz, A.B. and Papineni, P. (2021) Histoplasmosis. Infectious Disease Clinics of North America, 35, 471-491.
https://doi.org/10.1016/j.idc.2021.03.011
[2]  Venâncio de Barros, A., Sousa Gonçalves, F., Mendonça, L., Carvalho, D. and Melo Cristino, J. (2025) Histoplasma capsulatum Var. duboisii: A Case of Histoplasmosis 50 Years after the Exposure. Cureus, 17, e77854.
https://doi.org/10.7759/cureus.77854
[3]  Sepúlveda, V.E., Rader, J.A., Li, J., Goldman, W.E. and Matute, D.R. (2024) Phenotypic Characterization of Cryptic Species in the Fungal Pathogen Histoplasma. mSphere, 9, e924.
https://doi.org/10.1128/msphere.00009-24
[4]  Kasuga, T., White, T.J., Koenig, G., Mcewen, J., Restrepo, A., Castañeda, E., et al. (2003) Phylogeography of the Fungal Pathogen Histoplasma capsulatum. Molecular Ecology, 12, 3383-3401.
https://doi.org/10.1046/j.1365-294x.2003.01995.x
[5]  Teixeira, M.D.M., Patané, J.S.L., Taylor, M.L., Gómez, B.L., Theodoro, R.C., de Hoog, S., et al. (2016) Worldwide Phylogenetic Distributions and Population Dynamics of the Genus Histoplasma. PLOS Neglected Tropical Diseases, 10, e0004732.
https://doi.org/10.1371/journal.pntd.0004732
[6]  Lockhart, S.R., Toda, M., Benedict, K., Caceres, D.H. and Litvintseva, A.P. (2021) Endemic and Other Dimorphic Mycoses in the Americas. Journal of Fungi, 7, Article 151.
https://doi.org/10.3390/jof7020151
[7]  Taylor, M.L., Reyes-Montes, M.D.R., Estrada-Bárcenas, D.A., Zancopé-Oliveira, R.M., Rodríguez-Arellanes, G. and Ramírez, J.A. (2022) Considerations about the Geographic Distribution of Histoplasma Species. Applied and Environmental Microbiology, 88, e201021.
https://doi.org/10.1128/aem.02010-21
[8]  Jofre, G.I., Singh, A., Mavengere, H., Sundar, G., D’Agostino, E., Chowdhary, A., et al. (2022) An Indian Lineage of Histoplasma with Strong Signatures of Differentiation and Selection. Fungal Genetics and Biology, 158, Article 103654.
https://doi.org/10.1016/j.fgb.2021.103654
[9]  Benedict, K. and Mody, R.K. (2016) Epidemiology of Histoplasmosis Outbreaks, United States, 1938-2013. Emerging Infectious Diseases, 22, 370-378.
https://doi.org/10.3201/eid2203.151117
[10]  Guarner, J. and Brandt, M.E. (2011) Histopathologic Diagnosis of Fungal Infections in the 21st Century. Clinical Microbiology Reviews, 24, 247-280.
https://doi.org/10.1128/cmr.00053-10
[11]  Edwards, L.B., Acquaviva, F.A., Livesay, V.T., et al. (1969) An Atlas of Sensitivity to Tuberculin, PPD-B, and Histoplasmin in the United States. American Review of Respiratory Disease, 99, 1-132.
[12]  Manos, N.E., Ferebee, S.H. and Kerschbaum, W.F. (1956) Geographic Variation in the Prevalence of Histoplasmin Sensitivity. Diseases of the Chest, 29, 649-668.
https://doi.org/10.1378/chest.29.6.649
[13]  Akram, S.M. and Koirala, J. (2025) Histoplasmosis. Statpearls Publishing.
[14]  王蕤, 陈斌, 杜帅先, 等. 慢性乙型病毒性肝炎合并组织包浆菌病1例及文献复习[J]. 内科急危重症杂志, 2020, 26(2): 162-165.
[15]  吴颖, 李国红, 吴政光. 肺组织胞浆菌病的影像表现特征与鉴别[J]. 罕少疾病杂志, 2018, 25(3): 21-22.
[16]  Zhao, B., Xia, X., Yin, J., et al. (2001) Epidemiological Investigation of Histoplasma capsulatum Infection in China. Chinese Medical Journal, 114, 743-746.
[17]  Randhawa, H.S. (1970) Occurrence of Histoplasmosis in Asia. Mycopathologia et Mycologia Applicata, 41, 75-89.
https://doi.org/10.1007/bf02051485
[18]  Liu, X., Zhao, Z. and Zong, Z. (2024) Precise Geographical Distribution and Call for Accurate Identification of Histoplasmosis Cases in China. The Lancet Microbe, 5, Article 100943.
https://doi.org/10.1016/j.lanmic.2024.07.006
[19]  Pan, B., Chen, M., Pan, W. and Liao, W. (2012) Histoplasmosis: A New Endemic Fungal Infection in China? Review and Analysis of Cases. Mycoses, 56, 212-221.
https://doi.org/10.1111/myc.12029
[20]  Chen, L., Hu, D., Zhang, C., Wu, T., Cheng, X., Hagen, F., et al. (2023) Histoplasmosis: An Epidemiological and Clinical Update in China, Review and a Case Report. Mycology, 15, 101-109.
https://doi.org/10.1080/21501203.2023.2259934
[21]  Silva, D.L., Peres, N.T.A. and Santos, D.A. (2025) Key Fungal Coinfections: Epidemiology, Mechanisms of Pathogenesis, and Beyond. mBio, 16, e56225.
https://doi.org/10.1128/mbio.00562-25
[22]  Gildea, L.A., Morris, R.E. and Newman, S.L. (2001) histoplasma capsulatum Yeasts Are Phagocytosed via Very Late Antigen-5, Killed, and Processed for Antigen Presentation by Human Dendritic Cells. The Journal of Immunology, 166, 1049-1056.
https://doi.org/10.4049/jimmunol.166.2.1049
[23]  Kauffman, C.A. (2007) Histoplasmosis: A Clinical and Laboratory Update. Clinical Microbiology Reviews, 20, 115-132.
https://doi.org/10.1128/cmr.00027-06
[24]  Horwath, M.C., Fecher, R.A. and Deepe, G.S. (2015) Histoplasma capsulatum, Lung Infection and Immunity. Future Microbiology, 10, 967-975.
https://doi.org/10.2217/fmb.15.25
[25]  Tobón, A.M. and Gómez, B.L. (2021) Pulmonary Histoplasmosis. Mycopathologia, 186, 697-705.
https://doi.org/10.1007/s11046-021-00588-4
[26]  Ray, S.C. and Rappleye, C.A. (2019) Flying under the Radar: Histoplasma capsulatum Avoidance of Innate Immune Recognition. Seminars in Cell & Developmental Biology, 89, 91-98.
https://doi.org/10.1016/j.semcdb.2018.03.009
[27]  Sepúlveda, V.E., Williams, C.L. and Goldman, W.E. (2014) Comparison of Phylogenetically Distinct Histoplasma Strains Reveals Evolutionarily Divergent Virulence Strategies. mBio, 5, e1314-e1376.
https://doi.org/10.1128/mbio.01376-14
[28]  Rappleye, C.A., Eissenberg, L.G. and Goldman, W.E. (2007) Histoplasma capsulatum α-(1,3)-Glucan Blocks Innate Immune Recognition by the β-Glucan Receptor. Proceedings of the National Academy of Sciences, 104, 1366-1370.
https://doi.org/10.1073/pnas.0609848104
[29]  San-Blas, G., San-Blas, F. and Serrano, L.E. (1977) Host-Parasite Relationships in the Yeastlike Form of Paracoccidioides Brasiliensis Strain IVIC Pb9. Infection and Immunity, 15, 343-346.
https://doi.org/10.1128/iai.15.2.343-346.1977
[30]  Beyhan, S. and Sil, A. (2019) Sensing the Heat and the Host: Virulence Determinants of Histoplasma capsulatum. Virulence, 10, 793-800.
https://doi.org/10.1080/21505594.2019.1663596
[31]  Valdez, A.F., Miranda, D.Z., Guimarães, A.J., Nimrichter, L. and Nosanchuk, J.D. (2022) Pathogenicity & Virulence of histoplasma capsulatum—A Multifaceted Organism Adapted to Intracellular Environments. Virulence, 13, 1900-1919.
https://doi.org/10.1080/21505594.2022.2137987
[32]  Shen, Q., Ray, S.C., Evans, H.M., Deepe, G.S. and Rappleye, C.A. (2020) Metabolism of Gluconeogenic Substrates by an Intracellular Fungal Pathogen Circumvents Nutritional Limitations within Macrophages. mBio, 11, 1-19.
https://doi.org/10.1128/mbio.02712-19
[33]  Muñoz, B., Martínez, M.Á., Palma, G., Ramírez, A., Frías, M.G., Reyes, M.R., et al. (2010) Molecular Characterization of Histoplasma capsulatum Isolated from an Outbreak in Treasure Hunters. BMC Infectious Diseases, 10, Article No. 264.
https://doi.org/10.1186/1471-2334-10-264
[34]  Schmidt, T.E., Vieceli, T., Damasceno, L.S., Kimuda, S., Pasqualotto, A.C. and Bahr, N.C. (2025) Evolving Epidemiology, Improving Diagnostic Tests and Their Importance for the Correct Diagnosis of Histoplasmosis. Journal of Fungi, 11, Article 196.
https://doi.org/10.3390/jof11030196
[35]  Muniz, M.D.M., Pizzini, C.V., Peralta, J.M., Reiss, E. and Zancopé-Oliveira, R.M. (2001) Genetic Diversity of Histoplasma capsulatum Strains Isolated from Soil, Animals, and Clinical Specimens in Rio De Janeiro State, Brazil, by a PCR-Based Random Amplified Polymorphic DNA Assay. Journal of Clinical Microbiology, 39, 4487-4494.
https://doi.org/10.1128/jcm.39.12.4487-4494.2001
[36]  de Menezes, M.L.P., Cruz, K.S., Ogusku, M.M., da Silva, B.K.N.I., Alves, M.J., Grisolia, M.E., et al. (2024) Histoplasmosis in HIV/AIDS Patients in Amazonas, Northern Brazil. Brazilian Journal of Microbiology, 55, 1331-1337.
https://doi.org/10.1007/s42770-024-01277-2
[37]  Staffolani, S., Buonfrate, D., Angheben, A., Gobbi, F., Giorli, G., Guerriero, M., et al. (2018) Acute Histoplasmosis in Immunocompetent Travelers: A Systematic Review of Literature. BMC Infectious Diseases, 18, Article No. 673.
https://doi.org/10.1186/s12879-018-3476-z
[38]  Qureshi, N.Q., Foley, J., Mufarrih, S.H. and Kazimuddin, M. (2024) Pericardial Effusion in an Immunocompetent Host—A Unique Presentation of Histoplasmosis. Journal of Cardiology Cases, 29, 35-38.
https://doi.org/10.1016/j.jccase.2023.10.002
[39]  刘雪艳, 李春华, 舒伟强, 等. 急性肺组织胞浆菌病CT表现[J]. 中国医学影像技术, 2020, 36(11): 1643-1647.
[40]  Sizemore, T.C. (2013) Rheumatologic Manifestations of Histoplasmosis: A Review. Rheumatology International, 33, 2963-2965.
https://doi.org/10.1007/s00296-013-2816-y
[41]  刘雪艳, 李春华, 吕圣秀. 急性肺组织胞浆菌病CT影像学表现[C]//中国防痨协会. 第33届全国学术大会暨中国防痨科技奖颁奖大会论文集汇编. 2021: 516.
[42]  Babariya, H., Gaidhane, S.A., Acharya, S. and Kumar, S. (2024) Coccidioidomycosis and Histoplasmosis in Immunocompetent Individuals: A Comprehensive Review of Clinical Features, Diagnosis, and Management. Cureus, 16, e68375.
https://doi.org/10.7759/cureus.68375
[43]  Soeroso, N.N., Siahaan, L., Khairunnisa, S., Anggriani, R.A.H., Aida, A., Eyanoer, P.C., et al. (2024) The Association of Chronic Pulmonary Aspergillosis and Chronic Pulmonary Histoplasmosis with MDR-TB Patients in Indonesia. Journal of Fungi, 10, Article 529.
https://doi.org/10.3390/jof10080529
[44]  Alves, D.A., Trêpa, J., Sousa-Baptista, J., Pereira-Vaz, J. and Tomé, R. (2025) Disseminated Histoplasmosis as a Presentation of Advanced HIV-1 Infection in a Non-Endemic Country. Cureus, 17, e78571.
https://doi.org/10.7759/cureus.78581
[45]  Azar, M., Bahr, N., Loyd, J., Hage, C. and Wheat, L. (2015) Histoplasmosis: Up-to-Date Evidence-Based Approach to Diagnosis and Management. Seminars in Respiratory and Critical Care Medicine, 36, 729-745.
https://doi.org/10.1055/s-0035-1562899
[46]  Martínez-Gamboa, A., Niembro-Ortega, M.D., Torres-González, P., Santiago-Cruz, J., Velázquez-Zavala, N.G., Rangel-Cordero, A., et al. (2021) Diagnostic Accuracy of Antigen Detection in Urine and Molecular Assays Testing in Different Clinical Samples for the Diagnosis of Progressive Disseminated Histoplasmosis in Patients Living with HIV/AIDS: A Prospective Multicenter Study in Mexico. PLOS Neglected Tropical Diseases, 15, e0009215.
https://doi.org/10.1371/journal.pntd.0009215
[47]  Azar, M.M. and Hage, C.A. (2017) Laboratory Diagnostics for Histoplasmosis. Journal of Clinical Microbiology, 55, 1612-1620.
https://doi.org/10.1128/jcm.02430-16
[48]  Wheat, L.J., Freifeld, A.G., Kleiman, M.B., Baddley, J.W., McKinsey, D.S., Loyd, J.E., et al. (2007) Clinical Practice Guidelines for the Management of Patients with Histoplasmosis: 2007 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases, 45, 807-825.
https://doi.org/10.1086/521259
[49]  Animalu, C., Singh, N., Guice, K.C. and Maner, K. (2025) Febrile Pancytopenia and Hemophagocytosis from Disseminated Histoplasmosis in HIV/AIDS Patients: Two Cases and a Review of Combined Antifungal and Steroid Therapy. Case Reports in Infectious Diseases, 2025, Article 2623694.
https://doi.org/10.1155/crdi/2623694
[50]  Pasqualotto, A.C., Lana, D.D., Godoy, C.S.M., Leitão, T.D.M.J.S., Bay, M.B., Damasceno, L.S., et al. (2023) Single High Dose of Liposomal Amphotericin B in Human Immunodeficiency Virus/Aids-Related Disseminated Histoplasmosis: A Randomized Trial. Clinical Infectious Diseases, 77, 1126-1132.
https://doi.org/10.1093/cid/ciad313

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